Dopamine Antagonists as Anti-Emetics and as Stimulants of Gastric Motility

  • Brian McRitchie
  • Christine M. McClelland
  • Stephen M. Cooper
  • David H. Turner
  • Gareth J. Sanger
Part of the NATO ASI Series book series (volume 80)


Dopamine antagonists are commonly used to treat the symptoms of psychosis, where abnormal dopaminergic neuro-transmission in the brain is thought to be the primary cause of the illness1,2. Some dopamine antagonists however are not “anti-psychotic”, because they do not easily cross the blood-brain barrier or they only weakly antagonise the dopamine receptors involved in psychosis3. Among this latter group of antagonists are drugs which are used clinically to inhibit nausea and vomiting caused by a large number of different stimuli. Examples of such drugs include the substituted benzamides metoclopramide and clebopride, and the butyrophenone derivative, domperidone (Fig. 1).


Gastric Emptying Dopamine Receptor Test Meal Gastrointestinal Motility Gastric Motility 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Brian McRitchie
    • 1
  • Christine M. McClelland
    • 1
  • Stephen M. Cooper
    • 1
  • David H. Turner
    • 1
  • Gareth J. Sanger
    • 1
  1. 1.Medicinal Research CentreBeecham PharmaceuticalsHarlow, EssexUK

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