Neuro-Hormonal Control of Exocrine Pancreatic Secretion in Humans and Animals

  • Manfred V. Singer
Part of the NATO ASI Series book series (volume 80)


It is generally believed and written in many current medical text books that gastrointestinal hormones play a dominant physiological role in the control of pancreatic exocrine secretion in response to a meal. Many effects of vagal cholinergic nerves on pancreatic secretion are believed to be due to indirect effects on hormone release rather than direct effects on the pancreas. However, several recent studies support an important role for direct cholinergic vagal regulation of both enzyme and bicarbonate secretion from the pancreas.


Pancreatic Secretion Gastrointestinal Hormone Pancreatic Exocrine Secretion Bicarbonate Secretion Intestinal Phase 
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Suggested References for Further Reading

  1. Malagelada J.-R.: Gastric, pancreatic, and biliary responses to a meal. Physiology of the Gastrointestinal Tract, edited by L.R. Johnson, Raven Press, New York 1981, 893–924.Google Scholar
  2. Meyer J.H.: Control of pancreatic exocrine secretion. Physiology of the Gastrointestinal Tract, edited by L.R. Johnson, Raven Press, New York 1981, 821–829.Google Scholar
  3. Singer M.V., T.E. Solomon and M.I. Grossman: Effects of atropine on secretion from intact and transplanted pancreas in the dog. Am. J. Physiol. 238: G18–22 (1980).PubMedGoogle Scholar
  4. Singer M.V., T.E. Solomon, J. Wood and M.I. Grossman: Latency of pancreatic enzyme response to intraduodenal stimulants. Am. J. Physiol. 238: G23–29 (1980).PubMedGoogle Scholar
  5. Singer M.V., T.E. Solomon, H. Rammert, F. Caspary, W. Niebel, H. Goebell and M.I. Grossman: Effect of atropine on pancreatic response to HCl and secretin. Am. J. Physiol. 240: G376–380 (1981).PubMedGoogle Scholar
  6. Singer M.V., W. Niebel, D. Hoffmeister, J. Elsahoff and H. Goebell: Dose response effects on pancreatic response to low doses of secretin. Gastroenterology 82: 1182 (1982) (Abstract).Google Scholar
  7. Singer M.V.: Latency of pancreatic fluid secretory response to intestinal stimulants in the dog. J. Physiol. 339: 75–85 (1983).PubMedGoogle Scholar
  8. Solomon T.E. and M.I. Grossman: Effect of atropine and vagotomy on transplanted pancreas. Am. J. Physiol. 236: E186–190 (1979).PubMedGoogle Scholar
  9. Solomon T.E.: Neuro-hormonal control of the pancreas. In: Gut Hormones, edited by S.R. Bloom and J.M. Polak, Churchill Livingstone, Edinburgh, London, Melbourne and New York 1981, 499–503.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Manfred V. Singer
    • 1
  1. 1.Medizinische Klinik und Poliklinik, Abt. GastroenterologieUniversitätsklinikum EssenEssen 1Federal Republic of Germany

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