Intestinal Absorption and Secretion of Fluid and Electrolytes

  • Henry J. Binder
Part of the NATO ASI Series book series (volume 80)


Knowledge of the mechanisms that regulate small and large intestinal fluid and electrolyte movement has greatly expanded during the past decade. Detailed examination of individual transport processes present in the intestinal epithelia has provided insight into the control of both absorptive and secretory events. Studies of man have emphasized that the fluid load to the intestine is considerably greater than that previously appreciated and that diarrhea is almost always secondary to changes in fluid and electrolyte movement. Finally, the heterogeneity of various segments of the intestine has become increasingly evident and must be appreciated in the development of models to explain the overall control of fluid and electrolyte movement in health and disease.


Apical Membrane Sodium Absorption Fluid Load Active Potassium Absorptive Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    H.J. Binder, Absorption and secretion of water and electrolytes by small and large intestine, "Gastrointestinal Diseases", M.H. Sleisenger and J.S. Fordtran, eds., W.B. Saunders Co., Philadelphia, (1983).Google Scholar
  2. 2.
    P.S. Aronson., Identifying secondary active solute transport in epithelia. Am. J. Physiol., 9: Fl (1981).Google Scholar
  3. 3.
    H.N. Nellans, R.A. Frizzell, and S.G. Schultz, Brush-border processes and transepithelial Na and CI transport by rabbit ileum. Am. J. Physiol., 226: 1131 (1974).PubMedGoogle Scholar
  4. 4.
    C.M. Liedtke and U. Hopfer, Mechanism of Cl-translocation across small intestinal brush-border membrane. I. Absence of Na+-Cl-cotransport, Am. J. Physiol., 242: G263 (1982).PubMedGoogle Scholar
  5. 5.
    R.F. Gregor and E. Schlatter, Coupled transport of 2 CI-, 1 Na+ and 1 K+ at the luminal membrane of the rabbit cortical thick ascending limb of Henle’s loop (CTAL), Proc. Am. Soc. Nephrol., 14: 147 (1981).Google Scholar
  6. 6.
    J.S. Fordtran, Stimulation of active and passive sodium absorption by sugars in the human jejunum, J. Clin. Invest., 55: 728 (1975).PubMedCrossRefGoogle Scholar
  7. 7.
    K. Heintze, C.P. Stewart, and R.A. Frizzell, Sodium-dependent chloride secretion across rabbit descending colon. Am. J. Physiol., 244: G357 (1983).PubMedGoogle Scholar
  8. 8.
    S. Guandalini, M.C. Rao, P.L. Smith, and M. Field, cGMP modulation of ileal ion transport: in vitro effects of Escherichia coli heat-stable enterotoxin. Am. J. Physiol., 243: G36 (1982).PubMedGoogle Scholar
  9. 9.
    M.A. Balaa and D.W. Powell, Prostaglandin synthesis by isolated rabbit small intestinal enterocytes. Gastroenterology, 84: 1098 Abstract (1983).Google Scholar
  10. 10.
    E.S. Foster, G.I. Sandle, J.P. Hayslett, and H.J. Binder, Cyclic AMP stimulates active potassium secretion in the rat colon. Gastroenterology, 84: 324 (1983).PubMedGoogle Scholar
  11. 11.
    E.S. Foster, J.P. Hayslett, and H.J. Binder, Regulation of active potassium absorption and secretion in rat distal colon. Gastroenterology, 84: 1157 Abstract (1983).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Henry J. Binder
    • 1
  1. 1.Department of Interal MedicineYale University School of MedicineNew HavenUSA

Personalised recommendations