The Information Content of Single Channel Data

  • Joseph Patlak


Single channel signals were initially observed in artificial bilayer membranes (Bean et al., 1969; Gordon and Haydon, 1972; Hladkey and Haydon, 1972). They were first seen in biological membranes using the patch clamp technique (Neher and Sakmann, 1976). A number of excellent reviews have detailed this technique, including gigohm (>109 ohm) seals and ultra-high resolution recordings, as well as the many different types of preparations and channels from which recordings have been made (Neher et al., 1978; Hamill et al., 1981). In this chapter I will examine a different aspect of this subject. I seek to clarify the reasons for recording single channels, instead of measuring the mean behavior of a population of channels (whole cell recording), or the fluctuations caused by the random activity of such a population.


Single Channel Closed Time Single Channel Conductance Single Channel Current Channel Open Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Joseph Patlak
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of VermontBurlingtonUSA

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