Mast-Cell Growth Factor: Its Role in Mast-Cell Differentiation, Proliferation, and Maturation

  • Yee-Pang Yung
  • Malcolm A. S. Moore


The mast cell was first recognized as granular cells in the unstained mesentery of frog by Friedrich von Recklinghausen early in 1863. In 1879, using a staining procedure, Paul Ehrlich termed these granular cells mast cells. The mast cell is generally considered a connective tissue cell that possesses the capacity to accumulate metachromatically staining cytoplasmic granules (Selye, 1965; Fernex and Riley, 1968). Mast cells may differ substantially in size and shape, depending on their location and state of maturation. They are widely distributed throughout the body in connective tissues, particularly around small blood vessels, nerves, glandular ducts, the submucosa of the digestive tract, oral and nasal mucosa, the lining of the respiratory tract, and in the skin. Mast cells are rarely found in the brain or in parenchymatous organs, but are present in capsular connective tissue and the stroma of various lymphatic organs and endocrine glands (Selye, 1965; Valtonen, 1961; Pretlow and Cassady, 1970). Histochemically, their cytoplasm and the granules contain a variety of biologically active compounds, the most important being the anticoagulant heparin, the mediators of allergic reactions (e.g., histamine, serotonin, and slow-reacting substance), as well as various enzymes (Selye, 1965; Buisseret, 1982). Much information is available on the mechanism of immunoglobulin E (IgE) antibody-mediated mast-cell degranulation, and on their role in allergic reactions and inflammatory responses (Pepys and Edwards, 1979; Buisseret, 1982), yet the normal physiological role of mast cells is still obscure.


Mast Cell Mucosal Mast Cell Adherent Layer Connective Tissue Mast Cell Culture Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aglietta, M., Camussi, G., and Piacibello, W., 1981, Exp. Hematol. 9:95.PubMedGoogle Scholar
  2. Bartlett, P. F., 1982, Proc. Natl. Acad. Sci. USA 79:2722.PubMedCrossRefGoogle Scholar
  3. Befus, A. D., Pearce, F. L., Gauldie, J., Horsewood, P., and Bienenstock, J., 1982, J. Immunol. 128:2475.PubMedGoogle Scholar
  4. Broxmeyer, H. E., 1982a, J.Clin. Invest. 69:632.PubMedCrossRefGoogle Scholar
  5. Broxmeyer, H. E., 1982b, J.Immunol. 129:1002.Google Scholar
  6. Broxmeyer, H. E., Smithyman, A., Eger, R. R., Meyers, P. A., and DeSousa, M., 1978, J. Exp. Med. 148:1052.PubMedCrossRefGoogle Scholar
  7. Broxmeyer, H. E., Ralph, P., Bognacki, J., Kincade, P. W., and DeSousa, M., 1980, J. Immunol 125:903.PubMedGoogle Scholar
  8. Broxmeyer, H. E., Pelus, L. M., Gillis, S., Kincade, P., DeSousa, M., and Moore, M. A. S., 1981, in: Heterogeneity of Mononuclear Phagocytes (M. Landy and O. Forester, eds.), pp. 153–155, Academic Press, New York.Google Scholar
  9. Buisseret, P. D., 1982, Sci. Am. 247:86.PubMedCrossRefGoogle Scholar
  10. Burgess, A. W., Metcalf, D., Russell, S. H. M.Nicola, N. A., 1980, Biochem. J. 185:301.PubMedGoogle Scholar
  11. Burgess, A. W., and Metcalf, D., 1980, Blood 56:947.PubMedGoogle Scholar
  12. Burnet, F. M; 1965, J. Pathol 89:271.CrossRefGoogle Scholar
  13. Burnet, F. M., 1977, Cell Immunol. 30:358.PubMedCrossRefGoogle Scholar
  14. Breithaupt, H., and Haberman, E., 1969, Naunyn Schmiedebergs Arch. Pharmacol. 261:252.CrossRefGoogle Scholar
  15. Castro-Malaspina, H., Wang, S. Y., Lee, J. S., and Moore, M. A. S., 1982,Blood 60 (Suppl. 1) abst. 349.Google Scholar
  16. Clark-Lewis, I., and Schrader, J., 1981, J.Immunol 127:1941.PubMedGoogle Scholar
  17. Czarnetzki, B. M., 1981, Fed. Proc. 40:1026 (abst.).Google Scholar
  18. Dexter, T. M., and Lajtha, L. G., 1916, Bibl. Haematol 43:1.Google Scholar
  19. Ehrlich, P., 1879, Arch. Anat. Physiol (Lpz) Physiol Abt. 166.Google Scholar
  20. Fauser, A. A., Neuman, H. A., Bross, K. G., Kanz, L., and Lohr, G. W., 1982, Blood 60: 1317.Google Scholar
  21. Fernex, M., 1968, The Mast-Cell System, its Relationship to Atherosclerosis, Fibrosis, and Eosinophils, Williams and Wilkins, Baltimore.Google Scholar
  22. Galli, S. J., Dvorak, A. M., Marcum, J. A., Ishizaka, T., Nabel, G., Simonian, H. D., Pyne, K., Goldin, J. M., Rosenberg, R. D., Cantor, H., and Dvorak, H. F., 1982, J. Cell Biol 95: 435.PubMedCrossRefGoogle Scholar
  23. Ginsburg, H., and Lagunoff, D., 1967, Cell Biol 35:685.CrossRefGoogle Scholar
  24. Ginsburg, H., and Sachs, L., 1962, J. Natl Cancer Inst. 31:1.Google Scholar
  25. Ginsburg, H., Nir, I., Hammel, I., Eren, R., Weissman, B.-A., and Naot, Y., 1978, Immunology 35:485.PubMedGoogle Scholar
  26. Ginsburg, H., Olson, E. C., Huff, T. F., Okudaira, H., and Ishizaka, T., 1981, Int. Arch. Allergy Appl. Immunol. 66:447.PubMedCrossRefGoogle Scholar
  27. Ginsburg, H., Ben-Shahan, D., and Ben-David, E., 1982,Immunology 45:371.PubMedGoogle Scholar
  28. Greenberger, J. S., Gano, P. J., Davisson, P. B., and Moloney, W. C., 1979, Blood 53:987.PubMedGoogle Scholar
  29. Guy-Grand, D., Griscelli, C., and Vassalli, P., 1978, J.Exp. Med. 148:1661.PubMedCrossRefGoogle Scholar
  30. Haig, D. M., McKee, T. A., and Jarrett, E. E. E., 1982, Nature 300:188.PubMedCrossRefGoogle Scholar
  31. Hara, H., Ohe, Y., Noguchi, K., Tsuyama, K., and Kitamura, Y., 1982, Cell Tissue Kinet. 15:25.PubMedGoogle Scholar
  32. Hasthorpe, S., 1980, J.Cell Physiol 105:379.PubMedCrossRefGoogle Scholar
  33. Hatanaka, K., Kitamura, Y., and Nishimune, Y., 1979, Blood 53:142.PubMedGoogle Scholar
  34. Ihle, J. N., Rebar, L., Keller, J., Lee, J. C., and Hapel, A., 1982a, Immunol Rev. 63:5.PubMedCrossRefGoogle Scholar
  35. Ihle, J., Keller, J., Greenberger, J. S., Henderson, L., Yetter, R. A., and Morse, H. C., 1982b, J. Immunol 129:1377.Google Scholar
  36. Ihle, J., Keller, J., Henderson, L., Klein, F., and Palaszynski, E., 1982c, J. Immunol 129: 2431.PubMedGoogle Scholar
  37. Ihle, J., Keller, J., Oroszlan, S., Henderson, L. E., Copeland, T. D., Fitch, F., Prystowsky, M. B., Goldwasser, E., Schrader, J. W., Palaszynski, E., Dy, M., and Lebel, B., 1983, J.Immunol 131:282.PubMedGoogle Scholar
  38. Iscove, N. N., Roitsch, C. A., Williams, N., and Guilbert, L. J., 1982, J.Cell Physiol Suppl 1:65.PubMedCrossRefGoogle Scholar
  39. Ishizaka, T., Okudaira, H., Mauser, L. E., and Ishizaka, K., 1976, J.Immunol 116:747.PubMedGoogle Scholar
  40. Johnson, G. R., and Metcalf, D., 1980,.Exp. Hematol. 8:549.PubMedGoogle Scholar
  41. Jones-Villeneuve, E. V., and Phillips, R. A., 1980,Exp. Hematol 8:65.PubMedGoogle Scholar
  42. Kitamura, Y., Go, S., and Hatanaka, K., 1978, Blood 52:447.PubMedGoogle Scholar
  43. Kitamura, Y., Matsuda, H., and Hatanaka, K., 1979a, Nature 281:154.PubMedCrossRefGoogle Scholar
  44. Kitamura, Y., Shimada, M., Go, S., Matsuda, H., Hatanaka, K., and Seki, M., 1979b, J. Exp. Med. 150:482.PubMedCrossRefGoogle Scholar
  45. Kobata, A., Grollman, E. F., and Ginsburg, V., 1968, Biochim. Biophys. Res. Commun. 32: 272.CrossRefGoogle Scholar
  46. Kurland, J., and Moore, M. A. S., 1977, in: Experimental Hematology Today (S. J. Baum and G. D. Ledney, eds.), pp. 51–62, Springer-Verlag, New York.CrossRefGoogle Scholar
  47. Kurland, J. I., Pelus, L. M., Ralph, P., Bockman, R. S., and Moore, M. A. S., 1979, Proc.Natl Acad. Sci. USA 76:2326.PubMedCrossRefGoogle Scholar
  48. Lee, J. C., Hapel, A. J., and Ihle, J. N., 1982, J. Immunol 128:2393.PubMedGoogle Scholar
  49. Lennert, K., and Parwaresch, M. R., 1979, Histopathol. 3:349.CrossRefGoogle Scholar
  50. McCarthy, J. H., Mandel, T. E., Garson, O. M., and Metcalf, D., 1980, Exp. Hematol 8:562.PubMedGoogle Scholar
  51. Matsuda, H., and Kitamura, Y., 1981, Exp. Hematol 9:38.PubMedGoogle Scholar
  52. Metcalf, D., and Moore, M. A. S., 1971, Hematopoietic Cells, Elsevier-North-Holland, Amsterdam.Google Scholar
  53. Moore, M. A. S., 1982, in: Recent Advances in Haematology (A. V. Hoffbrand, ed.),pp. 109- 142, Churchill Livingstone, New York.Google Scholar
  54. Moore, M. A. S., and Dexter, T. M., 1978, Transplant Proc. 10:83.PubMedGoogle Scholar
  55. Moore, M. A. S., and Sheridan, A. P., 1982, in: Maturation Factors and Cancer (M. A. S. Moore, ed.), pp. 361–376, Raven Press, New YorkGoogle Scholar
  56. Moore, M. A. S., and Yung, Y. P., 1982, in: Expression of Differentiated Functions in Cancer Cells (R. F. Revoltella, G. M. Pontieri, C. Basilico, G. Rovera, R. C. Gallo, and J. H. Subak-Sharpe, eds.), pp. 213–221, Raven Press, New York.Google Scholar
  57. Mori, Y., Akedo, H., Tanaka, K., Tanigaki, Y., and Okada, M., 1979, Exp. Cell. Res. 118: 15.PubMedCrossRefGoogle Scholar
  58. Mori, Y., Akedo, H., Tanigaki, Y., Tanaka, K. M., Okada, M., and Nakamura, N., 1980, Exp. Cell. Res. 127:465.PubMedCrossRefGoogle Scholar
  59. Nabel, G., Galli, S. J., Dvorak, A. M., Dvorak, H. F., and Cantor, H., 1981, Nature 291:332.PubMedCrossRefGoogle Scholar
  60. Nagao, K., Yokoro, K., and Aaronson, S. A., 1981, Science 212:333.PubMedCrossRefGoogle Scholar
  61. Nakahata, T., and Ogawa, 1982, Proc. Natl. Acad. Sci. USA 79:3843.PubMedCrossRefGoogle Scholar
  62. Paff, G. H., Bloom, F., and Reilly, C., 1947, J.Exp. Med. 86:117.PubMedCrossRefGoogle Scholar
  63. Peius, L. M., Broxmeyer, H. E., and Moore, M. A. S., 1981, Cell Tissue Kinet. 14:515.Google Scholar
  64. Peius, L. M., Saletan, S., Silver, R. T., and Moore, M. A. S., 1982, Blood 59:284.Google Scholar
  65. Pepys, J., and Edwards, A. M. (eds.), 1979, The Cell: Its Role in Health and Disease, Pitman Medical, New York.Google Scholar
  66. Pfizenmaier, K., Rollionghoff, M., and Wagner, H., 1982, Curr. Top. Microbiol. Immunol. 100:203.PubMedCrossRefGoogle Scholar
  67. Potter, J. E. R., and Wright, E. G., 1980, Am. J. Hematol. 8:361.PubMedCrossRefGoogle Scholar
  68. Pretlow, T. G., and Cassady, I. M., 1970, Am. J. Pathol. 61:323.PubMedGoogle Scholar
  69. Ralph, P., Moore, M. A. S., and Nilsson, K., 1976, J. Exp. Med. 143:1828.CrossRefGoogle Scholar
  70. Razin, E., Stevens, R. L., Akiyama, F., Schmid, K., and Austen, K. F., 1982, J.Biol. Chem. 257:7229.PubMedGoogle Scholar
  71. Ruitenberg, E. J., and Elgersma, A., 1976, Nature 264:258.PubMedCrossRefGoogle Scholar
  72. Schrader, J. W., 1981, J.Immunol. 126:452.PubMedGoogle Scholar
  73. Schrader, J. W., and Clark-Lewis, I., 1982a, J.Immunol. 129:30.PubMedGoogle Scholar
  74. Schrader, J. W., and Clark-Lewis, I., 1982b, Curr. Top. Microbiol Immunol 100:221.PubMedCrossRefGoogle Scholar
  75. Schrader, J. W., Clark-Lewis, I., and Culvenor, J. G., 1981, Proc. Natl. Acad. Sci. USA 78: 323.PubMedCrossRefGoogle Scholar
  76. Selye, H., 1965, The Mast Cells, Butterworths, Washington.Google Scholar
  77. Sheridan, J. W., and Metealf, D., 1973, J.Cell. Physiol. 81:11.PubMedCrossRefGoogle Scholar
  78. Stanley, E. R., Hansen, G., Woodcock, J., and Metealf, D., 1975, Fed. Proc. 34:2272.PubMedGoogle Scholar
  79. Stanley, E. R., Cifone, M., Hear, P. M., and Defendi, V., 1976, J.Exp. Med. 143:631.PubMedCrossRefGoogle Scholar
  80. Tertian, G., Yung, Y.-P., and Moore, M.A.S., 1980, J.Supramol. Struct. 13:533.PubMedCrossRefGoogle Scholar
  81. Tertian, G., Yung, Y.-P., Guy-Grand, D., and Moore, M. A. S., 1981, J.Immunol 127:788.PubMedGoogle Scholar
  82. Valtonen, E. J., 1961,,Acta. Pathol Microbiol Scand. Suppl. 151, pp. 1–96.PubMedGoogle Scholar
  83. Wang, S. Y., Castro-Malaspina, H., and Moore, M. A. S., 1984a (submitted).Google Scholar
  84. Wang, S. Y., Castro-Malaspina, H., Lu, L., and Moore, M. A. S., 1984b, Blood (in press).Google Scholar
  85. Wlodarski, K., Morrison, K., and Rose, N. R., 1982, Scand. J. Immunol. 15:105.PubMedCrossRefGoogle Scholar
  86. Yung, Y.-P., and Moore, M.A.S., 1982, J.Immunol. 129:1256.Google Scholar
  87. Yung, Y.-P., Tertian, G., and Moore, M. A. S., 1980, Fourth International Congress of Immunology (abst.) 13.3.19.Google Scholar
  88. Yung, Y.-P., Eger, R., Tertian, G., and Moore, M. A. S., 1981, J. Immunol 127:794PubMedGoogle Scholar
  89. Yung, Y.-P., Wang, S. Y., and Moore, M. A. S., 1983, J. Immunol 130:2843.PubMedGoogle Scholar
  90. Zitcer, E. M., Elsasser, W. H., and Kirk, P. L., 1953, Growth 17:111.PubMedGoogle Scholar
  91. Zucker-Franklin, D., 1980, Blood 56:534.PubMedGoogle Scholar
  92. Zucker-Franklin, D, Grusky, G., Hirayama, N., and Schnipper, E., 1981, Blood 58:544.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Yee-Pang Yung
    • 1
  • Malcolm A. S. Moore
    • 1
  1. 1.Department of Developmental HematopoiesisSloan-Kettering Institute for Cancer ResearchNew YorkUSA

Personalised recommendations