Interleukin-2 and the Regulation of Natural Killer Activity in Cultured Cell Populations

  • Colin G. Brooks
  • Christopher S. Henney


The recent immunology literature is replete with examples of effector T-cell populations, the proliferation and function of which are potentiated by culture medium containing Interleukin-2 (IL-2), formerly T-cell growth for factor (TCGF). Indeed, it is often taken as axiomatic that all T cells can respond to IL-2, in conjunction with other signals, and, conversely, that all cells that respond to IL-2 are T cells. An apparent exception to this general rule was provided by the observation that IL-2 could enhance natural killer (NK) activity and that medium containing this lymphokine could support the continuous growth of cell lines with NK-like activity. This chapter reviews the now extensive literature pertaining to these phenomena and describes some newer data that demonstrate some interesting and previously undocumented interrelationships between cytotoxic T cells (CTL) and NK cells.


Natural Killer Spleen Cell Cytolytic Activity Natural Killer Activity Natural Killer Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Plenum Press, New York 1985

Authors and Affiliations

  • Colin G. Brooks
    • 1
  • Christopher S. Henney
    • 2
  1. 1.Program in Basic ImmunologyFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Immunex CorporationSeattleUSA

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