In Vivo Administratration of Interleukin-2

  • Martin A. Cheever
  • Philip D. Greenberg


Interleukin-2 (IL-2), also known as T-cell growth factor (TCGF), induces the replication of antigen-activated T cells in vitro. However, little is known concerning its function in vivo as a pharmacologic agent. The purpose of this chapter is to review evidence from animal models that IL-2 administered in vivo can induce T-cell growth in vivo and thereby augment specific T-cell immunity. In addition, an attempt is made to identify clinical immunodeficiency states in which the administration of IL-2 might be therapeutic; some of the potential toxicities of IL-2 and effects on immunity that might limit its use as a systemic reagent are discussed.


Spleen Cell Host Mouse Serum Inhibitor Ongoing Immune Reaction Immunoregulatory Circuit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Martin A. Cheever
    • 1
  • Philip D. Greenberg
    • 2
  1. 1.Division of OncologyUniversity of Washington School of MedicineSeattleUSA
  2. 2.Fred Hutchinson Cancer Research CenterSeattleUSA

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