Ordered and Disordered Growth of Renal Cells
Hyperplasia of tubular cells has been linked to cystic disease of the kidney for more than a century (Sturm, 1875). A sequence of events leading from tubular cell hyperplasia to cyst formation is proposed in Fig. 1. First, there must be an inciting cause of cell proliferation and perhaps a genetic or acquired predisposition to respond to it. Once cell growth is initiated, proliferating epithelial cells pile up on the tubular wall and form adenomatous masses. These masses or polyps are thought to partially obstruct the passage of fluid down the nephron, thereby raising intratubular pressure, dilating the tubule wall, and eventually causing cysts to form.
KeywordsCyst Formation Cystic Disease Kidney Epithelial Cell Label Nucleus Potassium Depletion
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