Morphology of Polycystic Kidney Disease in Man and Experimental Models
Although diagnosis of polycystic kidney disease has been possible for many years, we still have only a limited understanding of the pathogenesis of the disease, partly because of the difficulty in obtaining human cystic kidneys in different stages of cyst formation. At present only a few human kidneys with early-onset polycystic changes have been evaluated for both structural and functional changes (Baert, 1978). Therefore, growing attention has been given to various animal models that possess lesions that mimic human polycystic kidney disease (Goodman et al., 1970; Carone et al., 1974; Gardner et al., 1976; Evan and Gardner, 1976, 1979; Evan et al., 1979). There are presently three types of animal models for experimental polycystic kidney disease: (1) chemically induced, (2) traumatically induced, and (3) genetically transmitted. The chemically induced models have received the most attention in that a large number of compounds have been reported to produce cysts in small laboratory animals. Furthermore, these models allow opportunity to follow the acquisition and sequential growth of cysts. Of the various renal cytogens, three compounds, all of which are antioxidants, have received the greatest attention. These substances are diphenylamine (DPA), nordihydro-guaiaretic acid (NDGA), and diphenylthiazole (DPT).
KeywordsCyst Wall Polycystic Kidney Disease Large Cyst Cystic Disease Kidney Capsule
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