The Loss of Renal Enzymes

A Risk Factor for Nutritional and Metabolic Disorders
  • Hani B. Affarah
  • Rajender K. Chawla
  • Julie C. Bleier
  • Elbert P. Tuttle
  • Daniel Rudman


Malnutrition is a common problem in patients with end-stage renal disease (ESRD), regardless of the mode of therapy (Coles, 1972; Blumenkrantz et al., 1976; Kopple, 1978; Bansal et al., 1980). The risk factors for malnutrition may be divided into two categories: (1) extrinsic factors, such as restricted diets prescribed by the physician (Berlyne et al., 1968; Sorenson and Kopple, 1968), catabolic illness (Nsouli et al., 1979; Dobkin et al., 1978), blood losses from the gastrointestinal tract (Linton et al., 1977) and during hemodialysis (Longnecker et al., 1974), and loss of protein (Blumenkrantz et al., 1981) and amino acids (Kopple et al., 1973) into the dialysate; and (2) intrinsic factors, such as hypophagia (Atkin-Thor et al., 1978), malabsorption of nutrients (Merrill and Tasch, 1976), abnormal metabolism of nutrients (Spannuth et al., 1977; Reiman, 1972), and loss of renal enzymes which catalyze the utilization or degradation of nutrients including their conversion to physiologically essential compounds.


Uremic Patient Maintenance Hemodialysis Carnitine Deficiency Creatine Synthesis Phosphoglycerate Dehydrogenase 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Hani B. Affarah
    • 1
  • Rajender K. Chawla
    • 1
  • Julie C. Bleier
    • 1
  • Elbert P. Tuttle
    • 1
  • Daniel Rudman
    • 2
  1. 1.Clinical Research Facility and Division of Nephrology, Department of MedicineEmory University School of MedicineAtlantaUSA
  2. 2.Divison of Geriatric MedicineVeterans Administration Medical CenterNorth ChicagoUSA

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