Immunogenetics of HLA

  • Fritz H. Bach


The major approaches used for detection of major histocompatibility complex (MHC)-encoded antigens involve serologic methods; there are serologically detected determinants that are recognized on essentially all cells of the body and others that have an apparently more restricted tissue distribution.(1–3) In addition, there are cellular methods, studying activation of T lymphocytes in mixed leukocyte culture (MLC), that can be used to define MHC-encoded determinants. Here, also, determinants can be divided into two categories including those that activate much of the proliferative response in a primary mixed-leukocyte culture in which the donors of the responding and stimulating cells differ by an entire MHC, and those that are recognized by cytotoxic T lymphocytes.(4)


Major Histocompatibility Complex Serologic Method Normal Human Bone Marrow Mixed Leukocyte Culture Cellular Method 
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  1. 1.
    Terasaki PI (ed): Histocompatibility Testing 1970. Copenhagen, Munksgaard, 1970.Google Scholar
  2. 2.
    Kissmeyer-Nielsen F (ed): Histocompatibility Testing 1975. Copenhagen, Munksgaard, 1975.Google Scholar
  3. 3.
    Bodmer WF, Batchelor Jr, L, Bodmer JG, Festenstein H, Morris PJ (eds): Histocompatibility Testing 1977. Copenhagen, Munksgaard, 1978.Google Scholar
  4. 4.
    Bach FH, Bach ML, Sondel PM: Differential function of major histocompatibility complex antigens in T-lymphocyte activation. Nature 259:273, 1976.PubMedCrossRefGoogle Scholar
  5. 5.
    Mempel W, Grosse-Wilde H, Baumann P, Netzel B, Steinbauer-Rosenthal I: Population genetics of the MLC response: Typing for MLC determinants using homozygous and heterozygous reference cells. Transpl Proc 5:1529, 1973.Google Scholar
  6. 6.
    Reinsmoen N, Noreen H, Friend P, Giblett E, Greenberg L, Kersey J: Anomalous mixed lymphocyte culture reactivity between HLA-A, B, C, DR identical siblings. Tissue Antigens 13:19, 1979.PubMedCrossRefGoogle Scholar
  7. 7.
    Sheehy, MH, Sondel PM, Bach ML, Wank R, Bach FH: LD (lymphocyte defined) typing: A rapid assay with primed lymphocytes. Science 188:1308, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Bach FH, Jarrett-Toth, EK, Benike CJ, Shih CY, Valentine EA: Primed LD typing: Reagent preparation and definition of the HLA-D region antigens. ScandJ Immunol 6:469, 1977.CrossRefGoogle Scholar
  9. 9.
    Reinsmoen NL, Noreen HJ, Sasazuki T, Segali M, Bach FH: Roles of HLA-DR and HLA-D antigens in haplotype-primed LD typing reagents, in Kaplan JG (ed): The Molecular Basis of Immune Cell Function, Proceedings of the 13th International Leucocyte Culture Conference. Amsterdam, Elsevier/North-Holland, 1979.Google Scholar
  10. 10.
    Morgan DA, Ruscetti FW, Gallo RC: Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193:1007, 1976.PubMedCrossRefGoogle Scholar
  11. 11.
    Bach FH, Inouye H, Hank JA, Alter BJ: Human T lymphocyte clones reactive in primed lymphocytes typing and cytotoxicity. Nature 281:307, 1979.PubMedCrossRefGoogle Scholar
  12. 12.
    Long MA, Handwerger BS, Amos DB, Yunis EJ: The genetics of cell mediated lympholysis. J Immunol 117:2092, 1976.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Fritz H. Bach
    • 1
  1. 1.Immunobiology Research Center and Departments of Laboratory Medicine/Pathology and SurgeryUniversity of Minnesota HospitalsMinneapolisUSA

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