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Immunogenetics of HLA

  • Fritz H. Bach

Abstract

The major approaches used for detection of major histocompatibility complex (MHC)-encoded antigens involve serologic methods; there are serologically detected determinants that are recognized on essentially all cells of the body and others that have an apparently more restricted tissue distribution.(1–3) In addition, there are cellular methods, studying activation of T lymphocytes in mixed leukocyte culture (MLC), that can be used to define MHC-encoded determinants. Here, also, determinants can be divided into two categories including those that activate much of the proliferative response in a primary mixed-leukocyte culture in which the donors of the responding and stimulating cells differ by an entire MHC, and those that are recognized by cytotoxic T lymphocytes.(4)

Keywords

Major Histocompatibility Complex Serologic Method Normal Human Bone Marrow Mixed Leukocyte Culture Cellular Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Fritz H. Bach
    • 1
  1. 1.Immunobiology Research Center and Departments of Laboratory Medicine/Pathology and SurgeryUniversity of Minnesota HospitalsMinneapolisUSA

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