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Cyclosporin A as an Immunosuppressive Agent in Transplantation

  • R. Y. Calne

Abstract

Cyclosporin A (CyA) is an immunosuppressive agent that has exciting major interest because of its potential. Borei discovered its in vitro and in vivo immunosuppressive properties in a screening program of fungal products. CyA is a cyclic peptide of 11 amino acids. CyA is highly soluble in alcohol and fat solvents but it is totally insoluble in aqueous solutions. Borel’s(1) demonstration of prolongation of skin graft survival between mice differing for the H2 locus led David White, in my department, to suggest investigation of CyA in an organ allograft model. Our initial studies(2) showed that the agent prolongs survival of heterotopic hearts in rats across an AGB incompatability barrier.

Keywords

Renal Allograft Kidney Graft Kidney Allograft Heterotopic Pancreas Pancreas Allograft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • R. Y. Calne
    • 1
  1. 1.Department of Surgery, School of MedicineCambridge UniversityCambridgeEngland

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