Cyclosporin A as an Immunosuppressive Agent in Transplantation
Cyclosporin A (CyA) is an immunosuppressive agent that has exciting major interest because of its potential. Borei discovered its in vitro and in vivo immunosuppressive properties in a screening program of fungal products. CyA is a cyclic peptide of 11 amino acids. CyA is highly soluble in alcohol and fat solvents but it is totally insoluble in aqueous solutions. Borel’s(1) demonstration of prolongation of skin graft survival between mice differing for the H2 locus led David White, in my department, to suggest investigation of CyA in an organ allograft model. Our initial studies(2) showed that the agent prolongs survival of heterotopic hearts in rats across an AGB incompatability barrier.
KeywordsRenal Allograft Kidney Graft Kidney Allograft Heterotopic Pancreas Pancreas Allograft
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