Renal Cystic Disease as the Target of Research

  • Kenneth D. GardnerJr.


Cystic diseases account for 10% of all end-stage kidney disease (Cleveland and Fellner, 1979). Through Medicaid and Medicare their treatments cost our society about $200 million annually. Federal support for research into these conditions—their cause(s), prevention, arrest, and detection—approximates $500,000 a year. That is to say, of every federal dollar spent on renal cystic disease, more than 99 cents goes for treatment; less than 1 cent goes for research. This pittance of $500,000 reflects not defective central management but rather a relative lack in the field of interested, qualified investigators who are competitive for federal research dollars.


Cyst Formation Polycystic Kidney Disease Renal Cyst Cyst Fluid Cystic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Baert, L., 1978, Hereditary polycystic kidney disease (adult form): A microdissection study of two cases at an early stage of the disease, Kidney Int. 13:519.PubMedCrossRefGoogle Scholar
  2. Baert, L., and Steg, A., 1977, Is the diverticulum of the distal and collecting tubulus a preliminary stage of the simple cyst in the adult? J. Urol. 118:707.PubMedGoogle Scholar
  3. Boyland, E., Dukes, C. E., Grover, P. L., and Mitchley, B. C. V., 1962, The induction of renal tumors by feeding lead acetate to rats, Br. J. Cancer 16:283.PubMedCrossRefGoogle Scholar
  4. Bricker, N. S., and Patton, J. F., 1955, Cystic disease of the kidney: Study of dynamics and chemical composition of cyst fluid, Am. J. Med. 18:207.PubMedCrossRefGoogle Scholar
  5. Carone, F. A., Rowland, R. G., Perlman, S. G., and Ganote, C. E., 1974, The pathogenesis of drug-induced renal cystic disease, Kidney Int. 5:411.PubMedCrossRefGoogle Scholar
  6. Cleveland, W., and Fellner, S. K., 1979, Hereditary nephropathies as a cause of end-stage renal disease, Dialysis Transplant 8:633.Google Scholar
  7. Cuttino, J. T., Herman, P. G., and Mellins, H. Z., 1977, The renal collecting system after medullary damage, Investigative Radiol. 12:241.CrossRefGoogle Scholar
  8. Dalgaard, O. Z., 1957, Bilateral polycystic disease of the kidneys, Acta Med. Scand. (suppl) 328:17.Google Scholar
  9. Dunnill, M. S., Millard, P. R., and Oliver, D., 1977, Acquired cystic disease of the kidneys: A hazard of long-term intermittent maintenance hemodialysis, J. Clin. Pathol. 30:868.PubMedCrossRefGoogle Scholar
  10. Editorial, 1969, The enigma of familial polycystic kidneys, N. Engl. J. Med. 281:1013.Google Scholar
  11. Evan, A. P., and Gardner, K. D., Jr., 1979, Nephron obstruction in nordihydroguaiaretic acid-induced renal cystic disease, Kidney Int. 15:7.PubMedCrossRefGoogle Scholar
  12. Evan, A. P., Hong, S. K., Gardner, K. D., Jr., Park, Y. S., and Itagaki, R., 1978, Evolution of the collecting tubular lesion in diphenylamine-induced renal disease, Lab. Invest. 35:93.Google Scholar
  13. Evan, A. P., Gardner, K. D., Jr., Bernstein, J., 1979, Polypoid and papillary epithelial hyperplasia: A potential cause of ductal obstruction in adult polycystic disease, Kidney Int. 16:743.PubMedCrossRefGoogle Scholar
  14. Gardner, K. D., Jr., 1969, Composition of fluid in twelve cysts of a polycystic kidney, N. Engl. J. Med. 281:985.PubMedCrossRefGoogle Scholar
  15. Gardner, K. D., Jr., 1981, Cyst function in adult polycystic kidney disease, in: Controversies in Nephrology (G. Schreiner, ed.), Nephrology Division, University of Georgetown Press, Washington, D.C., pp. 279–285.Google Scholar
  16. Huseman, R., Grady, A., Welling, D., and Grantham, J., 1980, Macropuncture study of polycystic disease in adult human kidneys, Kidney Int. 18:375.PubMedCrossRefGoogle Scholar
  17. Jacobson, L., Lindquist, B., Michaelson, G., and Bjerle, P., 1977, Fluid Turnover In Renal Cysts, Acta Med. Scand. 202:327.CrossRefGoogle Scholar
  18. Lambert, P. P., 1947, Polycystic disease of the kidney: A review, Arch. Pathol. 44:34.Google Scholar
  19. McGeogh, J. E. M., and Darmady, E. M., 1975, Polycystic disease of kidney, liver and pancreas; a possible pathogenesis, J. Pathol. 119:221.CrossRefGoogle Scholar
  20. Muther, R. S., and Bennett, W. M., 1980, Cyst fluid antibiotic levels in polycystic kidney disease: Differences in proximal and distal cyst permeability, Abstracts of The American Society of Nephrology, p. 26A.Google Scholar
  21. Nauwerck, C., and Huischmid, K., 1893, Uber das multiloculare adenokystom der niere, Beitr. Path. Anat. 12:1.Google Scholar
  22. Oliver, J., MacDowell, M., and Tracy, A., 1951, Pathogenesis of acute renal failure associated with traumatic and toxic injury. Renal ischemia nephrotoxic damage, and the ischaemic episode, J. Clin. Invest. 30:1305.CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Kenneth D. GardnerJr.
    • 1
  1. 1.Department of MedicineUniversity of New Mexico School of MedicineAlbuquerqueUSA

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