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Total Lymphoid Irradiation for Immunosuppression

Review of Animal Experiments and Results of a Clinical Trial in Renal Allograft Recipients
  • David E. R. Sutherland
  • Ronald M. Ferguson
  • Richard L. Simmons
  • Tae H. Kim
  • Shimon Slavin
  • John S. Najarian

Abstract

The therapeutic immunosuppressive effects of ionizing radiation were applied to transplant patients as long as 25 years ago by administration of full-body irradiation to prospective renal allograft recipients. The radiation dose required to prolong allograft survival produced severe bone marrow and other toxicities, and this approach was virtually abandoned by the mid-1960s.(1) Since then, various attempts have been made to direct radiation specifically at immunocompetent lymphoid cells,(2) including by local graft irradiation,(3) intralymphatic(4) or intravenous(5) administration of radioisotopes that focus upon lymphatic tissue, and by extracorpeal irradiation of blood(6) and lymph.(7) The radiation dose delivered by these techniques is difficult to control. The effect on allograft survival also has been variable, so that clinical application has been limited.

Keywords

Graft Survival Renal Allograft Transpl Proc Graft Versus Host Disease Rejection Episode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • David E. R. Sutherland
    • 1
  • Ronald M. Ferguson
    • 1
  • Richard L. Simmons
    • 1
  • Tae H. Kim
    • 1
  • Shimon Slavin
    • 1
  • John S. Najarian
    • 1
  1. 1.Departments of Surgery and Therapeutic RadiologyUniversity of MinnesotaMinneapolisUSA

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