Use of Total Lymphoid Irradiation in Organ Transplantation
In the course of investigating the cellular basis of the immunodeficiency of patients with Hodgkin’s disease, we examined the number and function of T lymphocytes in the peripheral blood before and after treatment with total lymphoid irradiation (TLI).(1) Treated patients received a total of 4400 rads to the lymph nodes, thymus, and spleen (if not removed previously), in fractions of 200–250 rads to the subdiaphragmatic tissues. A similar schedule of radiation was given subsequently to the supradiaphragmatic tissues. The skull, lungs, kidneys, pelvis, and long bones were shielded with lead.
KeywordsBone Marrow Cell Skin Graft Allogeneic Bone Marrow Antithymocyte Globulin Total White Blood Cell Count
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- 2.Kaplan HS: Hodgkin’s Disease. 2nd edition. Cambridge, Mass., Harvard University Press, 1980.Google Scholar