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Use of Total Lymphoid Irradiation in Organ Transplantation

  • S. Strober
  • M. S. Gottlieb
  • R. T. Hoppe
  • C. P. Bieber
  • D. P. Paulnock
  • B. L. Kotzin
  • S. H. Koretz
  • B. A. Reitz
  • H. S. Kaplan

Abstract

In the course of investigating the cellular basis of the immunodeficiency of patients with Hodgkin’s disease, we examined the number and function of T lymphocytes in the peripheral blood before and after treatment with total lymphoid irradiation (TLI).(1) Treated patients received a total of 4400 rads to the lymph nodes, thymus, and spleen (if not removed previously), in fractions of 200–250 rads to the subdiaphragmatic tissues. A similar schedule of radiation was given subsequently to the supradiaphragmatic tissues. The skull, lungs, kidneys, pelvis, and long bones were shielded with lead.

Keywords

Bone Marrow Cell Skin Graft Allogeneic Bone Marrow Antithymocyte Globulin Total White Blood Cell Count 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • S. Strober
    • 1
  • M. S. Gottlieb
    • 2
  • R. T. Hoppe
    • 3
  • C. P. Bieber
    • 4
  • D. P. Paulnock
    • 5
  • B. L. Kotzin
    • 6
  • S. H. Koretz
    • 7
  • B. A. Reitz
    • 8
  • H. S. Kaplan
    • 3
  1. 1.Division of Immunology, Department of MedicineStanford University Medical CenterStanfordUSA
  2. 2.Division of Clinical Immunology (CIA), Department of MedicineUCLA Center for the Health SciencesLos AngelesUSA
  3. 3.Department of RadiologyStanford University Medical CenterStanfordUSA
  4. 4.Los Altos HillsUSA
  5. 5.Department of Medical MicrobiologyUniversity of Wisconsin Medical SchoolMadisonUSA
  6. 6.Division of Rheumatology, Department of Internal MedicineMedical CenterDenverUSA
  7. 7.Institute of Clinical MedicineSyntex ResearchPalo AltoUSA
  8. 8.Department of SurgeryJohns Hopkins Medical SchoolBaltimoreUSA

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