The Role of Membrane Biocompatibility on the Clinical Effects of Hemodialysis Therapy

  • Edmund G. Lowrie


There has been increasing interest in biomaterials research during the past several years. This is true in a number of areas of clinical endeavor, but these comments are confined to artificial kidney systems. Figure 1 illustrates a continuum for the development of dialysis therapies from the invention of new membranes through the optimization of clinical treatment. We have been interested in and involved with clinical evaluation of new and established artificial kidneys for a number of years, as shown in the second panel of the figure. More recently, we have been privileged to participate in a clinical trial that evaluates the control of blood urea nitrogen concentration by using pharmacokinetics and the effect this may have on clinical outcome, as shown by panels 3 and 4. Recent data suggest, however, that there may be a direct link between the biomaterials used to manufacture artificial kidneys and the clinical effects of therapy. In other words, Fig. 1 should probably be redrawn to show a direct connection between panels 1 and 4.


Regenerate Cellulose Dialysis Therapy Artificial Kidney Hemodialysis Therapy Foreign Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yen MC, Ball JH, Lowrie EG, Lazarus JM, Hampers CL, Merrill JP: The effect of androgens and dialysis on erythropoiesis in chronic renal failure. Proc Dial Transpl Forum 3:33–37, 1973.Google Scholar
  2. 2.
    Hochmuth RM, Mohandas N, Spaeth EE, Williamson JR, Blackshear PL Jr, Johnson DW: Surface adhesion, deformation and detachment at low shear of red cells and white cells. Tr Am Soc Artif Intern Organs 18:325–332, 1972.CrossRefGoogle Scholar
  3. 3.
    Sandza JG, Clark RD, Weldon CS, Sutera SP: Subhemolytic trauma of erythrocytes: Recognition and sequestration by the spleen as a function of shear. Tr Am Soc Artif Intern Organs 20:457, 1974.Google Scholar
  4. 4.
    Hakim, RL, Lowrie EG: Hemodialysis associated neutropenia and hypoxemia: The effect of dialyzer membrane materials. Nephron 32:32–39, 1982.PubMedCrossRefGoogle Scholar
  5. 5.
    Bjorksten B, Mauer SM, Mills EL, Quie PG: The effect of neutrophil chemotactic responsiveness. Acta Med Scand 203:67, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacob HS: Hemodialysis leukopenia: Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. J Clin Invest 59:879, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    Lowrie EG, Hakim RM: The effect on patient health of using reprocessed artificial kidneys. Clin Dial Transplant Forum, November 1980, pp 86–91.Google Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Edmund G. Lowrie
    • 1
  1. 1.National Medical CareWalthamUSA

Personalised recommendations