The Role of Membrane Biocompatibility on the Clinical Effects of Hemodialysis Therapy
There has been increasing interest in biomaterials research during the past several years. This is true in a number of areas of clinical endeavor, but these comments are confined to artificial kidney systems. Figure 1 illustrates a continuum for the development of dialysis therapies from the invention of new membranes through the optimization of clinical treatment. We have been interested in and involved with clinical evaluation of new and established artificial kidneys for a number of years, as shown in the second panel of the figure. More recently, we have been privileged to participate in a clinical trial that evaluates the control of blood urea nitrogen concentration by using pharmacokinetics and the effect this may have on clinical outcome, as shown by panels 3 and 4. Recent data suggest, however, that there may be a direct link between the biomaterials used to manufacture artificial kidneys and the clinical effects of therapy. In other words, Fig. 1 should probably be redrawn to show a direct connection between panels 1 and 4.
KeywordsRegenerate Cellulose Dialysis Therapy Artificial Kidney Hemodialysis Therapy Foreign Surface
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