Pathogenesis of Aminoglycoside Nephrotoxicity

  • Friedrich C. Luft


The effect of aminoglycoside antibiotics on the kidneys has been the subject of considerable interest, not only because of its clinical importance,(1) but also because of the useful acute renal failure model produced by these compounds. Although the pathogenesis of aminoglycoside nephrotoxicity remains incompletely defined, the work of numerous investigators has produced much information from a variety of diverse sources. The contributions of pharmacologists, physiologists, biochemists, pathologists, and clinicians provide a framework that should encourage further investigations of aminoglycoside nephrotoxicity in particular, and the pathogenesis of acute renal failure in general.


Antimicrob Agent Aminoglycoside Antibiotic Myeloid Body Renal Cortical Slice Aminoglycoside Nephrotoxicity 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Friedrich C. Luft
    • 1
  1. 1.Renal Section, Department of MedicineIndiana University School of MedicineIndianapolisUSA

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