Deposition of Circulating Immune Complexes in Glomeruli

  • Mart Mannik


Experimental and clinical investigations have established the relationship between circulating immune complexes and the deposition of immune complexes in glomeruli. In spontaneous disease models, in models induced by antigen administration, and in human glomerulonephritis the principal locations of immune complexes are in the subendothelial, mesangial, and subepithelial areas. The presence of immune complexes in glomeruli can result from local formation, as reviewed in the paper by Dr. Curtis B. Wilson, or from deposition of these substances from circulation. The purpose of this review is to consider the pertinent information on glomerular deposition of circulating immune complexes.


Immune Complex Glomerular Basement Membrane Circulate Immune Complex Immune Deposit Mesangial Area 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Mart Mannik
    • 1
  1. 1.Division of Rheumatology, Department of MedicineUniversity of WashingtonSeattleUSA

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