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Contrast Media Acute Renal Failure

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Chronic Renal Disease

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Abstract

Several observations point to the possibility that contrast-induced vascular alterations could be the common pathway for contrast-related cases of acute renal failure. Porter and Associates(1) noted that iothalamate, when injected into the left ventricle of the dog, resulted in an increase in cardiac output and caused a 25% decrease in renal blood flow. When isoosmolar quantities of mannitol were injected, however, the same increase in cardiac output occurred, but renal blood flow increased. Transient decreases in renal plasma flow and glomerular filtration rate occur after large-dose excretory urography.(2–4) In fact, noncontrast hypertonic solutions also produce this effect.(5) The response tends to be biphasic showing initially a transient increase in renal flood flow followed by a more prolonged (10–20%) decrease in renal blood flow which may persist for up to 1 hr.

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Authors and Affiliations

  1. Veterans Administration Medical Center, University of Texas Southwestern Medical School, Dallas, Texas, 75216, USA

    Robert E. Cronin

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  1. Robert E. Cronin
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Editors and Affiliations

  1. Washington University School of Medicine, St. Louis, Missouri, USA

    Saulo Klahr M.D.

  2. National Institutes of Health, Bethesda, Maryland, USA

    Nancy Boucot Cummings M.D.

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© 1985 Plenum Publishing Corporation

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Cronin, R.E. (1985). Contrast Media Acute Renal Failure. In: Cummings, N.B., Klahr, S. (eds) Chronic Renal Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4826-9_39

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  • DOI: https://doi.org/10.1007/978-1-4684-4826-9_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4828-3

  • Online ISBN: 978-1-4684-4826-9

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