Drug-Induced Nephrotoxicity

  • Mark H. Gardenswartz
  • Jan P. Goldberg
  • Robert W. Schrier


Physicians have become increasingly aware that the promise and potential of the current pharmacopeia is but one blade of a double-edged sword. Drug-induced disease is an alarming problem in every area of medical endeavor and indeed has had a major impact on the incidence, nature, and natural history of commonly encountered renal disease (Table 1). The broad array of modern nephrotoxins includes, among others, the penicillin homologues and antifungal, antiinflammatory, and antineoplastic agents. However, this introduction will concentrate on the two classes of drugs of greatest epidemiologic importance, i.e., radioiodinated contrast materials and aminoglycoside antibiotics.


Multiple Myeloma Acute Renal Failure Renal Insufficiency Antimicrob Agent Chronic Renal Insufficiency 


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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Mark H. Gardenswartz
    • 1
  • Jan P. Goldberg
    • 1
  • Robert W. Schrier
    • 1
  1. 1.Department of MedicineUniversity of Colorado Health Sciences CenterDenverUSA

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