Renal Osteodystrophy in Children

  • Russell W. Chesney


The association between renal insufficiency and bone disease has been recognized for more than 100 years since Lucas, in 1883, described anemia, dwarfism, and “late form of rickets” in children with chronic renal failure.(1) Although the term renal rickets has been used to describe this bone disorder, the clinical and histologic differences between vitamin D deficiency and juvenile renal osteodystrophy are sizable. Advanced osteodystrophy consists of bone pain, metaphyseal fractures, osteitis fibrosa cystica, delayed bone age, linear growth failure, severe bowing, and slipped epiphyses.(2) Mehls et al.(3) have made the point that childhood uremic bone disease has a unique epiphyseal lesion, largely related to secondary hyperparathyroidism, that is histologically distinct from D deficiency and which accounts for the widened growth plate and for retardation in bone age (Fig. 1). Childhood uremic osteodystrophy has certain real differences from adult renal bone disease (Table 1) that are often dramatically highlighted.(3–5)


Chronic Renal Failure Renal Osteodystrophy Concentration Of25 Osteitis Fibrosa Osteitis Fibrosa Cystica 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Russell W. Chesney
    • 1
  1. 1.Department of PediatricsUniversity of Wisconsin Center for the Health SciencesMadisonUSA

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