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Protein Utilization in Chronic Renal Insufficiency in Children

  • Warren E. Grupe
  • Nancy S. Spinozzi
  • William E. Harmon

Abstract

It is obvious that at least some of the toxic compounds responsible for uremia are metabolic products of protein catabolism. There is also ample evidence that protein metabolism is significantly altered in children with chronic renal insufficiency (Delaporte et al., 1976, 1978; Conley et al., 1980; Holliday et al., 1970; Grupe, 1981b). These studies, coupled with the empiric demonstration that low-protein diets alleviate many of the symptoms of uremia, have led to a precept that has now become axiomatic: stipulating low-protein intake in chronic renal insufficiency. There is, however, the rational goal of reducing the main dietary sources of hydrogen ion, phosphate, potassium, and sulfate to the lowest possible level commensurate with the patient’s renal function.

Keywords

Energy Intake Protein Intake Essential Amino Acid Nitrogen Balance Chronic Renal Insufficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Warren E. Grupe
    • 1
  • Nancy S. Spinozzi
    • 1
  • William E. Harmon
    • 1
  1. 1.Division of NephrologyThe Children’s HospitalBostonUSA

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