Nutritional Requirements for Growth in Children with Renal Insufficiency

  • Malcolm A. Holliday


Optimum requirements for growth in normal children are defined by the Recommended Dietary Allowances (RDAs) (National Research Council, Food and Nutrition Board, 1980). Given access to adequate food, it is assumed that normal children will have an appetite that assures an adequate intake of energy. Requirements for specific nutrients other than energy are usually met when children satisfy appetite for calories with customary foods. Specific nutrients are taken well in excess of RDA and, in many instances, the excess is excreted in urine. Dietary tolerances are generous in normal children (Holliday, 1976).


Energy Intake Chronic Renal Failure Plasma Lipid Continuous Ambulatory Peritoneal Dialysis Muscle Protein Synthesis 
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  1. Arnold, W. C., and Holliday, M. A., 1979a, Assessment of nutritional status in children with chronic renal failure, Kidney Int. 16:950.CrossRefGoogle Scholar
  2. Arnold, W. C., and Holliday, M. A., 1979b, Tissue resistance to insulin stimulation of amino acid uptake in acutely uremia rats, Kidney Int. 16:124–129.PubMedCrossRefGoogle Scholar
  3. Bagdade, J. D., Porte, D., and Blerman, E. L., 1968, Hypertriglyceridemia: A metabolic consequence of chronic renal failure, N. Engl. J. Med. 279:181.PubMedCrossRefGoogle Scholar
  4. Beeker, D. J., Pimstone, B. L., and Hausen, J. D. L., 1975, The relation between insulin secretion glucose tolerance, growth hormone and serum proteins in protein calorie malnutrition, Pediatr. Res. 9:35–39.Google Scholar
  5. Betts, P. R., and Magrath, G., 1974, Growth pattern and dietary intake of children with chronic renal insufficiency, Br. Med. J. 2:189.PubMedCrossRefGoogle Scholar
  6. Betts, P. R., Magrath, G., and White, R. H. R., 1977, Role of dietary energy supplementation in growth of children with chronic renal insufficiency, Br. Med. J. 1:416.PubMedCrossRefGoogle Scholar
  7. Bishti, M. M., Counahan, R., Stimmler, L., Jarrett, R. J., Wass, V. J., and Chantier, C., 1977, Abnormalities in plasma lipids in children of regular hemodialysis, Arch. Dis. Child. 52:932.PubMedCrossRefGoogle Scholar
  8. Brunzell, J. D., 1980, Triglycerides and coronary heart disease (letter), N. Engl. J. Med. 303:1060.PubMedCrossRefGoogle Scholar
  9. Caliguire, L. A., Shapiro, A. P., and Holliday, M. A., 1963, Clinical improvement in chronic renal hypertension in children, Pediatrics 31:758.Google Scholar
  10. Chantier, C., El-Bishti, M. M., Counahan, R., Wass, V. J., and Cox, B. D., 1976, Growth in children with renal failure, Melsunger Med. Mitteilungen 50(11):557.Google Scholar
  11. Chesney, R. W., Moorthy, V., Eisman, J. A., Jax, D. K., Mazess, R. B., and DeLuca, H. F., 1978, Increased growth after long term oral 1,25-vitamin D3 in childhood renal osteodystrophy, N. Engl. J. Med. 298:238–242.PubMedCrossRefGoogle Scholar
  12. Conley, S. B., Rose, G. M., Robson, A. M., and Bier, D. M., 1980, Effects of dietary intake and hemodialysis on protein turnover in uremic children, Kidney Int. 17:837–846.PubMedCrossRefGoogle Scholar
  13. DeFronzo, R. A., Tobin, J. D., Rowe, J. W., and Andres, R., 1978, Glucose intolerance in uremia, J. Clin. Invest. 62:425–435.PubMedCrossRefGoogle Scholar
  14. Ginsberg, H., Olefsky, J., Kimmerling, G., Crapo, P., and Reavan, G. M., 1976, Induction of hypertriglyceridemia by a low fat diet, J. Clin. Endocrinol. Metab. 42:729.PubMedCrossRefGoogle Scholar
  15. Goldberg, A. O., Hagberg, J., Delmez, J. A., Carney, R. M., McKevitt, P. M., Ehsaru, A. A., and Harter, H. R., 1980, The metabolic and psychological effects of exercise training in hemodialysis patients, Am. J. Clin. Nutr. 33:1620–1628.PubMedGoogle Scholar
  16. Grodstein, G. P., Blumenkrantz, M. J., and Kopple, J. D., 1980, Nutritional and metabolic response to stress, Am. J. Clin. Nutr. 33:1411–1416.PubMedGoogle Scholar
  17. Holliday, M. A., 1976, Management of the child with renal insufficiency, in: Clinical Pediatric Nephrology (E. Lieberman, ed.), Lippincott, Philadelphia.Google Scholar
  18. Holliday, M. A., Chantier, C., MacDonnell, R., and Keitges, J., 1977, Effect of uremia in nutritionally-induced variations in protein metabolism, Kidney Int. 11:236–245.PubMedCrossRefGoogle Scholar
  19. Holliday, M. A., McHenry, K., and Portale, A., 1979, Nutritional management of chronic renal disease, Med. Clin. North Am. 63:945.PubMedGoogle Scholar
  20. Kerr, D. S., Stevens, M. C. G., and Robinson, H. M., 1978a, Fasting metabolism in infants: I. Effect of severe undernutrition in energy and protein utilization, Metabolism 27:411–435.PubMedCrossRefGoogle Scholar
  21. Kerr, D. S., Stevens, M. C. G., and Picou, D. I. M., 1978b, Fasting metabolism in infants: II. The effect of severe undernutrition and infusion of alanine on glucose production estimated with U13 glucose, Metabolism 27:831–847.PubMedCrossRefGoogle Scholar
  22. Keys, A., Brozek, J., Henschel, A., Michelson, O., and Taylor, H. I., 1950, The Biology of Human Starvation, University of Minnesota Press, Minneapolis.Google Scholar
  23. Kleinknect, C., Broyer, M., Gagnadoux, M., Marte-Henneberg, C., Dartois, A. M., Kermanach, C., Pouliguen, M., Degoulet, P., Usbert, M., and Roy, M. P., 1980, Growth in children treated with long-term dialysis. A study of 76 patients, Adv. Nephrol. 9:133–163.Google Scholar
  24. McSherry, E., 1978, Acidosis and growth in nonuremic renal disease, Kidney Int. 14:349–354.PubMedCrossRefGoogle Scholar
  25. Mehls, O., Ritz, E., Gilli, G., Bartholome, K., BeiBbarth, H., Hohenegger, M., and Schafnitzel, W., 1980, Nitrogen metabolism and growth in experimental uremia, Int. J. Pediatr. Nephrol. 1(1):34–41.PubMedGoogle Scholar
  26. Moncrief, J. W., Popuvich, R. P., Holph, K. D., Rubin, J., Robson, M., Dombros, N., deVeber, G. A., and Oreopoulos, D. G., 1979, Clinical experience with continuous ambulatory peritoneal dialysis, ASAIO Journal 2:114–118.Google Scholar
  27. National Research Council, Food and Nutrition Board, 1980, Recommended Dietary Allowances, 9th ed., National Academy of Science, Washington, D.C.Google Scholar
  28. Olefsky, J. M., Farquhar, J. W., and Reavan, G. M., 1974, Reappraisal of the role of insulin in hypertriglyceridemia, Am. J. Med. 57:551.PubMedCrossRefGoogle Scholar
  29. Pennington, J. A., 1976, Dietary Nutrient Guide, Avi, Westport, Connecticut.Google Scholar
  30. Picou, D., and Taylor-Robert, T., 1969, The measurement of total protein synthesis and catabolism and nitrogen turnover in infants in different nutritional states and receiving different amounts of dietary protein, Clin. Sci. 35:283.Google Scholar
  31. Potter, D. E., McDaid, T. K., and Ramirez, J. A., 1980, Peritoneal dialysis in children, in: Proceedings of the Pan Pacific Symposium on Peritoneal Dialysis (R. Atkins, ed.), Churchill Livingstone, New York.Google Scholar
  32. Reavan, G. M., Swenson, R. S., and Sanfelippo, M. D., 1980, An inquiry into the mechanism of hypertriglyceridemia in patients with chronic renal failure, Am. J. Clin. Nutr. 33:1476–1484.Google Scholar
  33. Rubenfeld, S., and Garber, A. J., 1978, Abnormal CHO metabolism in CRF. The potential role of accelerated glucose production, increased gluconeogenesis and impaired glucose disposal. J. Clin. Invest. 62(1):20–28.PubMedCrossRefGoogle Scholar
  34. Sanfelippo, M. L., Swenson, R. S., and Reaven, G. M., 1977, Reduction of plasma triglycerides by diet in subjects with chronic renal failure, Kidney Int. 11:54–61.PubMedCrossRefGoogle Scholar
  35. Simmons, J. M., Wilson, C. J., Potter, D. E., and Holliday, M. A., 1971, Relation of calorie deficiency to growth failure in children on hemodialysis and the growth response to calorie supplementation, N. Engl. J. Med. 285:653–656.PubMedCrossRefGoogle Scholar
  36. Spady, D. W., Payne, P. R., Picou, D., and Waterlow, J. C., 1976, Energy balance during recovery from malnutrition, Am. J. Clin. Nurs. 29:1073–1078.Google Scholar
  37. Spencer, E. M., Uthne, K. O., and Arnold, W. C., 1979, Growth impairment with elevated somatomedin levels in children with chronic renal insufficiency, Acta Endocrinol. 91:36–48.PubMedGoogle Scholar
  38. West, C. D., and Smith, W. C., 1956, An attempt to elucidate the cause of growth retardation in renal disease, Am. J. Dis. Child. 91:460.Google Scholar
  39. Westervelt, F. B., 1969, Insulin effect in uremia, J. Lab Clin. Med. 74:79–84.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Malcolm A. Holliday
    • 1
  1. 1.Department of Pediatrics, School of MedicineUniversity of CaliforniaSan FranciscoUSA

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