Abnormal Carbohydrate and Lipoprotein Metabolism in Uremia

Possible Relationship to Atherogenesis
  • Gerald M. Reaven


There is a good deal of evidence which indicates that abnormalities of carbohydrate and lipid metabolism occur frequently in patients with chronic renal failure (CRF). Given the increased incidence of atherosclerotic heart disease (ASHD) in patients with diabetes and/or hyperlipoproteinemia, it seems reasonable to wonder if the accelerated atherogenesis described in patients with CRF is related to the coexistence of abnormal carbohydrate and lipid metabolism in these patients. In this chapter I will attempt to approach this question by defining the effects of the uremic syndrome on carbohydrate and lipid metabolism and then suggesting possible mechanisms by which these changes could lead to atherosclerosis.


Chronic Renal Failure Glucose Intolerance Lipoprotein Abnormality Plasma Insulin Response Hepatic Triglyceride Lipase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Gerald M. Reaven
    • 1
    • 2
  1. 1.Department of MedicineStanford University School of MedicineUSA
  2. 2.Geriatric Research, Education and Clinical CenterVeterans Administration Medical CenterPalo AltoUSA

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