Biosynthesis and Immunochemical Localization of Glomerular Components
The molecular composition of the glomerulus became a target of interest when Masugi (1934) first demonstrated that immunization of animals with kidney tissue resulted in a diffuse glomerular lesion. The search for the nephritogenic antigen, although not yet complete, has provided the impetus for many studies of glomerular structure and function. The importance of understanding the sites of synthesis and degradation of matrix constituents relates to (1) normal glomerular structure and function, (2) localization and disposition of immune deposits, (3) immunogenicity of individual components (i.e., cellular and humoral responses to glomerular constituents), and (4) genetic or acquired diseases resulting in an accumulation of abnormal matrix constituents resulting in loss of function—chronic glomerulonephritis.
KeywordsHeparan Sulfate Mesangial Cell Basal Lamina Glomerular Basement Membrane Glomerular Cell
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- Ausiello, D. A., Kreisberg, J. I., Roy, C., and Karnovsky, M. J., 1980, Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin, Am. J. Physiol. 65:756.Google Scholar
- Barajas, L., 1979, Anatomy of the juxtaglomerular apparatus, Am. J. Physiol. 237(5):F343.Google Scholar
- Johnson, A. R., and Erdos, E. G., 1978, Activities of enzymes in human pulmonary endothelial cells in culture, Circulation Suppl. II:108.Google Scholar
- Krakower, C. A., and Greenspan, S. A., 1951, Localization of nephrotoxic antigen within isolated renal glomerulus, Arch. Pathol. 51:629.Google Scholar
- Masugi, M., 1934, Uber die experimentelle Glomerulonephritis durch das spezifische Antini-erenserum. Ein Beitrag zur Pathogenese der diffusen Glomerulonephritis, Beitr. z. path. Anat. u. z. allg. Path. 92:429.Google Scholar
- Mohos, S. C., and Skoza, L., 1969, Further characterization of sialoglycoprotein glomerular antigen, Fed. Proc. 28:364.Google Scholar
- Striker, G. E., Savin, V., Agodoa, L., and Killen, P., 1976, Glomerular cells in vitro, Contrib. Neph. 2:25.Google Scholar