Biosynthesis and Immunochemical Localization of Glomerular Components

  • Gary E. Striker
  • Federico M. Farin
  • Paul D. Killen
  • Jeffrey F. Bonadio


The molecular composition of the glomerulus became a target of interest when Masugi (1934) first demonstrated that immunization of animals with kidney tissue resulted in a diffuse glomerular lesion. The search for the nephritogenic antigen, although not yet complete, has provided the impetus for many studies of glomerular structure and function. The importance of understanding the sites of synthesis and degradation of matrix constituents relates to (1) normal glomerular structure and function, (2) localization and disposition of immune deposits, (3) immunogenicity of individual components (i.e., cellular and humoral responses to glomerular constituents), and (4) genetic or acquired diseases resulting in an accumulation of abnormal matrix constituents resulting in loss of function—chronic glomerulonephritis.


Heparan Sulfate Mesangial Cell Basal Lamina Glomerular Basement Membrane Glomerular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Gary E. Striker
    • 1
  • Federico M. Farin
    • 1
  • Paul D. Killen
    • 1
  • Jeffrey F. Bonadio
    • 1
  1. 1.Department of PathologyUniversity of WashingtonSeattleUSA

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