Advertisement

Neurologic Complications of Renal Failure

The State of the Art
  • Allen I. Arieff

Abstract

In the patient with renal failure, the nervous system is the primary barometer of patient well-being. Whereas other manifestations of the uremic state such as anemia, heart failure, bone pain, muscle dysfunction, and skin rashes are evaluated by the physician, it is via the nervous system that patients with renal failure perceive that which is abnormal.(1)

Keywords

Renal Failure Acute Renal Failure Parathyroid Hormone Chronic Renal Failure Primary Hyperparathyroidism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Teschan PE, Ginn HE: The nervous system, in Massry SG, Sellers AL (eds): Clinical Aspects of Uremia and Dialysis. Springfield, Illinois, Charles C Thomas, 1976, pp 3–33.Google Scholar
  2. 2.
    Raskin NH, Fishman RA: Neurologic disorders in renal failure. N Engl J Med 294:143–148, 204–210, 1976.PubMedCrossRefGoogle Scholar
  3. 3.
    Arieff AI, Schmidt RW: Fluid and electrolyte disorders and the central nervous system, in Maxwell MH, Kleeman CR (eds): Clinical Disorders of Fluid and Electrolyte Metabolism. New York, McGraw-Hill, 1979, pp 1409–1480.Google Scholar
  4. 4.
    Fishman RA: Permeability changes in experimental uremic encephalopathy. Arch Int Med 126:835–837, 1970.CrossRefGoogle Scholar
  5. 5.
    van den Nort S, Eckel RE, Brine KL, Hrdlicka J: Brain metabolism in experimental uremia. Arch Int Med 126:831–834, 1970.CrossRefGoogle Scholar
  6. 6.
    Olsen S: The brain in uremia. Acta Psychiat Scand 36(Suppl 156): 1–128, 1961.Google Scholar
  7. 7.
    Burks JS, Alfrey AC, Huddlestone J, Norenberg MD, Lewin E: A fatal encephalopathy in chronic hemodialysis patients. Lancet 1:764–7689, 1976.PubMedCrossRefGoogle Scholar
  8. 8.
    Massry SG: Is parathyroid hormone a uremic toxin? Nephron 19:125–130, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    Black DAK: A perspective on uremic toxins. Arch Int Med 126:906–909, 1970.CrossRefGoogle Scholar
  10. 10.
    Arieff AI, Armstrong DK: Parathyroid hormone and uremic neurotoxicity: An unproven association. Contr Nephr 20:56–66, 1980.Google Scholar
  11. 11.
    Cooper JD, Lazarowitz VC, Arieff AI: Neurodiagnostic abnormalities in patients with acute renal failure: Evidence for neurotoxicity of parathyroid hormone. J Clin Invest 61:1448–1455, 1978.PubMedCrossRefGoogle Scholar
  12. 12.
    Arieff AI, Guisado R, Massry SG, Lazarowitz VC: Central nervous system pH in uremia and the effects of hemodialysis. J Clin Invest 58:306–311, 1976.PubMedCrossRefGoogle Scholar
  13. 13.
    Mahoney C, Arieff AI: Central and peripheral nervous system effects of chronic renal failure. Kidney Int 24:170–177, 1983.PubMedCrossRefGoogle Scholar
  14. 14.
    Guisado R, Arieff AI, Massry SG, Lazarowitz VC, Kerian A: Changes in the electroencephalogram in acute uremia: Effects of parathyroid hormone and brain electrolytes. J Clin Invest 55:738–745, 1975.PubMedCrossRefGoogle Scholar
  15. 15.
    Mallette LE, Bilezikian JP, Heath DA, Aurbach GD: Primary hyperparathyroidism: Clinical and biochemical features. Medicine 53:127–146, 1974.PubMedCrossRefGoogle Scholar
  16. 16.
    Heath H, Hodgson SF, Kennedy MA: Primary hyperparathyroidism. N Engl J Med 302:189–193, 1980.PubMedCrossRefGoogle Scholar
  17. 17.
    Cogan M, Covey CM, Arieff AI, Wisniewski A, Clark O, Lazarowitz VC, Leach WJ: Central nervous system manifestations of hyperparathyroidism. Am J Med 65:963–970, 1978.PubMedCrossRefGoogle Scholar
  18. 18.
    Nielsen VK: The peripheral nerve function in chronic renal failure: A survey. Acta Med Scand 573(Suppl):7–32, 1974.Google Scholar
  19. 19.
    Asbury AK, Victor M, Adams RD: Uremic polyneuropathy. Arch Neurol 8:413–428, 1963.PubMedCrossRefGoogle Scholar
  20. 20.
    Thomas PK, Hollinrake K, Lascelles RG, O’Sullivan DJ, Baillod RA, Moorhead JF, Mackenzie JC: The polyneuropathy of chronic renal failure. Brain 94:761–780, 1971.PubMedCrossRefGoogle Scholar
  21. 21.
    Giulio SD, Chkoff N, Lhoste F, Zingraff J, Drueke T: Parathormone as a nerve poison in uremia. N Engl J Med 299:1134–1135, 1978.PubMedGoogle Scholar
  22. 22.
    Ibrahim MM, Barnes AD, Crosland JM, Edwards PD, Honigsberger L, Newman CE, Robinson BHB: Effect of renal transplantation on uraemic neuropathy. Lancet 2:739–742, 1974.PubMedCrossRefGoogle Scholar
  23. 23.
    Arieff AI: Neurological complications of uremia, in Brenner BM, Rector FC (eds): The Kidney, Philadelphia, WB Saunders, 2nd ed, 1981, pp 2306–2343.Google Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Allen I. Arieff
    • 1
    • 2
  1. 1.Nephrology Service, Department of MedicineVeterans Administration Medical CenterUSA
  2. 2.University of California School of MedicineSan FranciscoUSA

Personalised recommendations