Collagen Metabolism in Uremia

  • Stephen M. Krane


Collagens are among the most abundant structural proteins of the extracellular matrix and are important components of basement membranes. Although many tissue collagens under normal circumstances have slow turnover rates (e.g., in dermis), other collagens are degraded and new collagens synthesized in the course of tissue remodeling (e.g., in bone). In chronic renal failure abnormalities occur in bone remodeling as well as lesions in dermis and subcutaneous tissue (necrosis) and tendons (spontaneous rupture). These changes should be interpreted with respect to our current knowledge of collagen metabolism.


Chronic Renal Failure Collagen Molecule Bone Collagen Collagen Metabolism Lysyl Residue 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Stephen M. Krane
    • 1
    • 2
  1. 1.Department of MedicineHarvard Medical SchoolUSA
  2. 2.Medical Services (Arthritis Unit)Massachusetts General HospitalBostonUSA

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