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Movement of Organic Molecules into Cysts

  • William M. Bennett
  • Curtis G. Wickre
  • Richard S. Muther

Abstract

Patients with polycystic kidney disease and intercurrent urinary tract infection may develop perinephric abscesses despite prolonged antibiotic treatment directed against susceptible urinary pathogens (Sweet and Keane, 1979). Sweet and Keane (1979), during a 3½-year period of observation, found that 8 of 24 dialysis patients with polycystic kidney disease developed symptomatic urinary infections. Of these, five patients developed perinephric abscesses despite more than 2 weeks of antibiotic treatment. This type of experience suggests that cystic nephrons may not achieve adequate concentrations of antibiotics for sterilization of infected fluid. Poor drainage of cystic nephrons due to outflow obstruction also might contribute to poor therapeutic response.

Keywords

Polycystic Kidney Disease Cyst Fluid Simple Renal Cyst General Clinical Research Center Perinephric Abscess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • William M. Bennett
    • 1
  • Curtis G. Wickre
    • 1
  • Richard S. Muther
    • 1
  1. 1.Division of Nephrology, Department of MedicineOregon Health Sciences UniversityPortlandUSA

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