Patients with polycystic kidney disease and intercurrent urinary tract infection may develop perinephric abscesses despite prolonged antibiotic treatment directed against susceptible urinary pathogens (Sweet and Keane, 1979). Sweet and Keane (1979), during a 3½-year period of observation, found that 8 of 24 dialysis patients with polycystic kidney disease developed symptomatic urinary infections. Of these, five patients developed perinephric abscesses despite more than 2 weeks of antibiotic treatment. This type of experience suggests that cystic nephrons may not achieve adequate concentrations of antibiotics for sterilization of infected fluid. Poor drainage of cystic nephrons due to outflow obstruction also might contribute to poor therapeutic response.
KeywordsPolycystic Kidney Disease Cyst Fluid Simple Renal Cyst General Clinical Research Center Perinephric Abscess
Unable to display preview. Download preview PDF.