Cell Membranes pp 219-246 | Cite as

Assembly and Establishment of Membrane-Cytoskeleton Domains During Differentiation

Spectrin as a Model System
  • W. James Nelson
  • Elias Lazarides


The multifunctional capability of the eukaryotic cell is expressed and regulated, to a great extent, by the cell type-specific biophysical properties of the plasma membrane. The plasma membrane is essentially a barrier comprising a phospholipid bilayer structure which acts also as a matrix onto which and into which a variety of specific proteins are attached. It is these proteins which selectively modify the structure and properties of the plasma membrane to create a wide variety of domains of distinctive morphology and function.


Terminal Differentiation Anion Transporter Stable Assembly Intestinal Brush Border Brain Spectrin 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • W. James Nelson
    • 1
  • Elias Lazarides
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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