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Cell Membranes pp 219–246Cite as

Assembly and Establishment of Membrane-Cytoskeleton Domains During Differentiation

Spectrin as a Model System

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Abstract

The multifunctional capability of the eukaryotic cell is expressed and regulated, to a great extent, by the cell type-specific biophysical properties of the plasma membrane. The plasma membrane is essentially a barrier comprising a phospholipid bilayer structure which acts also as a matrix onto which and into which a variety of specific proteins are attached. It is these proteins which selectively modify the structure and properties of the plasma membrane to create a wide variety of domains of distinctive morphology and function.

Work supported by grants from the National Institutes of Health (NIH), National Science Foundation, and the Muscular Dystrophy Association. W. James Nelson was also supported by a Cancer Research Campaign International Fellowship awarded by the International Union Against Cancer and a Senior Postdoctoral Fellowship from the American Heart Association, Los Angeles Affiliate. Elias Lazarides is the recipient of a Research Career Development Award from the NIH.

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Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    W. James Nelson & Elias Lazarides

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  1. W. James Nelson
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  2. Elias Lazarides
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Editors and Affiliations

  1. Washington University School of Medicine, St. Louis, Missouri, USA

    Elliot Elson , William Frazier  & Luis Glaser ,  & 

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© 1984 Plenum Press, New York

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Nelson, W.J., Lazarides, E. (1984). Assembly and Establishment of Membrane-Cytoskeleton Domains During Differentiation. In: Elson, E., Frazier, W., Glaser, L. (eds) Cell Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4823-8_6

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  • DOI: https://doi.org/10.1007/978-1-4684-4823-8_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4825-2

  • Online ISBN: 978-1-4684-4823-8

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