Cell Membranes pp 197-218 | Cite as

Regulation of Assembly of the Spectrin-Based Membrane Skeleton in Chicken Embryo Erythroid Cells

  • Randall T. Moon
  • Ingrid Blikstad
  • Elias Lazarides


How newly synthesized proteins are routed to their proper locations and assembled into higher-order structures within the cell remains a challenge to cell biology. The magnitude of the problem is considerable, given that some newly synthesized proteins such as secreted immunoglobulins (Dulis, 1983) are destined for secretion from cells, others such as many glycoproteins (Fitting and Kabat, 1982; Polonoff et al., 1982) or hormone or neurotransmitter receptors (Jacobs et al., 1983; Merlie et al., 1982) become integrated into the plasma membrane, and the remaining proteins reside in intracellular vesicles, membranes, cytoskeletal structures, the nucleus, or the cytoplasm. As illustrated below, the selection of a protein’s destination can be made either cotranslationally or posttranslationally.


Erythroid Cell Membrane Skeleton Nascent Chain Stabilization Hypothesis Cytoskeletal Fraction 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Randall T. Moon
    • 1
  • Ingrid Blikstad
    • 1
  • Elias Lazarides
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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