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Chemotactic Transduction in the Cellular Slime Molds

  • William A. Frazier
  • Beth L. Meyers-Hutchins
  • Gordon A. JamiesonJr.
  • Nancy J. Galvin

Abstract

Two eukaryotic cell types have been extensively studied as paradigms for the chemotaxis of freely motile cells: the leukocytes such as PMNs and macrophages (Neidel and Cuatrecasas, 1980; Schiffman, 1982; Zigmond, 1978) and the cellular slime molds, particularly the species Dictyostelium discoideum (Devreotes, 1982; Frazier et al., 1982; Gerisch, 1982). Both these systems have inherent complications for studying the mechanism(s) of chemotaxis per se, that is, the process or processes by which the occupancy of chemotactic receptors is sensed by the inner workings of the cell, specifically those components involved in cellular motility, and translated into directional information. The white cells respond to chemoattractants such as complement peptides and N-formylated peptides (e.g., F-Met-Leu-Phe, or FMLP) with a barrage of killer mechanisms such as superoxide and peroxide production, lysosomal enzyme secretion, increased cell-cell adhesiveness, and enhanced phagocytosis (Neidel and Curatrecasas, 1980; Schiffmann, 1982; Zigmond, 1978). Many or all of these responses may have nothing to do with the chemotactic response or effect on cell motility. In general, most chemoattractants also cause the response of chemo-kinesis, or an increase in rate of motility with no imposed directional component.

Keywords

Guanylate Cyclase Dictyostelium Discoideum Folate Receptor Slime Mold Chemotactic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • William A. Frazier
    • 1
  • Beth L. Meyers-Hutchins
    • 1
  • Gordon A. JamiesonJr.
    • 1
  • Nancy J. Galvin
    • 1
  1. 1.Departments of Biological Chemistry and Neurobiology, Division of Biology and Biomedical SciencesWashington University School of MedicineSt. LouisUSA

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