Ectopic Hormone Syndromes

  • Louis M. Sherwood
Part of the Contemporary Endocrinology book series (COE, volume 2)


While enormous progress has been made in recognizing the production of hormones by tumors, the pathogenesis of this phenomenon still remains obscure.1 Inherent in a complete understanding of the mechanisms is a fuller appreciation of the processes of normal cell proliferation, maturation, and differentiation. Any hypothesis satisfactory to explain the process must account for the following observations:
  1. 1.

    Polypeptide hormone production is extremely widespread in both normal tissues and tumors. 1–4

  2. 2.

    There are distinct histologic associations between tumor type and the nature of the hormone produced (see Table I).

  3. 3.

    Biosynthesis of hormones by tumors appears not to be the expression or activation of abnormal genes but of known genes for recognized polypeptide hormones or their precursors.



Human Chorionic Gonadotropin Medullary Thyroid Carcinoma Small Cell Carcinoma Medullary Carcinoma Radioreceptor Assay 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Louis M. Sherwood
    • 1
  1. 1.Department of MedicineAlbert Einstein College of MedicineBronxUSA

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