Aldosterone and Renin

  • Edward G. Biglieri
Part of the Contemporary Endocrinology book series (COE, volume 2)


To appreciate the origins of the steroids produced in the zona glomerulosa (ZG) and zona fasciculata (ZF), the reader is referred to Fig. 1. The unique steroids from the ZG are 18-hydroxycorticosterone (180H-B) and aldosterone. The contribution of ZG corticosterone (B) and deoxycorticosterone (DOC) to peripheral blood levels must be minimal because current evidence suggests that they are primarily ACTH-dependent and of ZF origin. Only in the 17α-hydroxylase deficiency type of congenital adrenal hyperplasia (CAH) does 18OH-B originate from the ZF. Angiotensin II is the principal regulator of this zone, but acute or short-term administration of ACTH stimulates 18OH-B and aldosterone.


Plasma Renin Activity Congenital Adrenal Hyperplasia Primary Aldosteronism Plasma Aldosterone Zona Glomer 


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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Edward G. Biglieri
    • 1
    • 2
  1. 1.Endocrinology Service of the Medical Services, and Clinical Study CenterSan Francisco General Hospital Medical CenterSan FranciscoUSA
  2. 2.Department of MedicineUniversity of California School of MedicineSan FranciscoUSA

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