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The Testis

  • Daniel D. Federman
Part of the Contemporary Endocrinology book series (COE, volume 2)

Abstract

This chapter on the testis follows the outline used in the past. As before, the aim is to present an integrated review rather than an exhaustive compilation of references. Similarly, the emphasis is selective and will, in particular, stress testicular differentiation, puberty and gonadotropinreleasing hormone (LRH), androgen action and resistance, and some new aspects of infertility.

Keywords

Luteinizing Hormone Leydig Cell Sperm Count Male Infertility Hypogonadotropic Hypogonadism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Büttler, E. M., 1980, A synopsis of the human Y chromosome, Hum. Genet. 55: 145–175.CrossRefGoogle Scholar
  2. 2.
    Short, R. V., 1978, Sex determination and differentiation of the mammalian gonad, Int. J. Androl. Suppl. 2: 21–28.CrossRefGoogle Scholar
  3. 3.
    Mailhes, J. B., Pittaway, D. E., Rary, J., Chen, H., and Grafton, W. D., 1979, H-Y antigen-positive male pseudohermaphroditism with 45,X/46,XYqmosaicism, Hum. Genet. 53: 57–63.PubMedCrossRefGoogle Scholar
  4. 4.
    Wachtel, S. S., and Koo, G. C., H-Y antigen in gonadal differentiation, in: Mechanisms of Sex Differentiation in Animals and Man (Austin, C.R., and Edwards, U.R., eds.), Academic Press, London.Google Scholar
  5. 5.
    Fraccaro, M., Tiepolo, L., Zuffardi, O., Chiumello, G., Di Natale, B., Gargantini, L., and Wolf, U., 1979, Familial XX true hermaphroditism and the H-Y antigen, Hum. Genet. 48: 45–52.PubMedCrossRefGoogle Scholar
  6. 6.
    Wolf, U., Fraccaro, M., Mayerovâ, A., Hecht, T., Zuffardi, O., and Hameister, H., 1980, Turner syndrome patients are H-Y positive, Hum. Genet. 54: 315–318.PubMedCrossRefGoogle Scholar
  7. 7.
    Wolf, U., Fraccaro, M., Mayerovâ A., Hecht, T., Maraschio, P., and Hameister, H., 1980, A gene controlling H-Y antigen on the X chromosome: Tentative assignment by deletion mapping to Xp223, Hum. Genet. 54: 149–154.PubMedCrossRefGoogle Scholar
  8. 8.
    Engel, W., Pfäfflin, F., and Wiedeking, C., 1980, H-Y antigen in transsexuality, and how to explain testis differentiation in H-Y antigen-negative males and ovary differentiation in H-Y antigen-positive females, Hum. Genet. 55: 315–319.PubMedCrossRefGoogle Scholar
  9. 9.
    Müller, U., Aschmoneit, I., Zenzes, M. T., and Wolf, U. W., 1978, Binding studies of H-Y antigen in rat tissues: Indications for a gonad-specific receptor, Hum. Genet. 43: 151–157.PubMedCrossRefGoogle Scholar
  10. 10.
    Schulte, M.J., 1979, Positive H-Y antigen testing in a case of XY gonadal absence syndrome, Clin. Genet. 16: 438–440.PubMedCrossRefGoogle Scholar
  11. 11.
    Griffin, J. E., and Wilson, J. D., 1980, The syndromes of androgen resistance, N. Engl. J. Med. 302: 198–209.PubMedCrossRefGoogle Scholar
  12. 12.
    Huhtaniemi, I., and Lautala, P., 1979, Stimulation of steroidogenesis in human fetal testes by the placenta during perifusion, J. Steroid Biochem. 10: 109–113.PubMedCrossRefGoogle Scholar
  13. 13.
    Feldman, K. W., and Smith, D. W., 1975. Fetal phallic growth and penile standards for newborn male infants, J. Pediatr. 86: 395–398.PubMedCrossRefGoogle Scholar
  14. 14.
    Naganami, M., McDonough, P. G., Ellegood, J. O., and Mahesh, V. B., 1979, Maternal and amniotic fluid steroids throughout human pregnancy, Am. J. Obstet. Gynecol. 134: 674–680.Google Scholar
  15. 15.
    Lox, C. D., 1978, Amniotic fluid androgens and their relationship to foetal sex, Int. J. Androl. 1: 471–476.CrossRefGoogle Scholar
  16. 16.
    Siler-Khodr, T. M., and Khodr, G. S., 1980, Studies in human fetal endocrinology. II. LH and FSH content and concentration in the pituitary, Obstet. Gynecol. 56: 176–181.PubMedGoogle Scholar
  17. 17.
    Wachtel, S. S., 1980, The dysgenetic gonad: Aberrant testicular differentiation, Biol. Reprod. 22: 1–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Wachtel, S. S., Koo, G. C., Breg, W. R., Thaler, H. T., Dillard, A. M., Rosenthal, I. M., Dosik, H., Gerald, P. S., Saenger, P., New, M., Lieber, E., and Miller, O. J., 1976, Serologic detection of a Y-linked gene in XX males and XX true hermaphrodites, N. Engl. J. Med. 295: 750–754.PubMedCrossRefGoogle Scholar
  19. 19.
    Winters, S. J., Wachtel, S. S., White, B. J., Koo, G. C., Javadpour, N., Loriaux, D. L., and Sherins, R. J., 1979, H-Y antigen mosaicism in the gonad of a 46,XX true hermaphrodite, N. Engl. J. Med. 300: 745–749.PubMedCrossRefGoogle Scholar
  20. 20.
    Elias, S., Martin, A. O., and Simpson, J. L., 1980, Stability of sex chromosome mosaicism, Am. J. Obstet. Gynecol. 136: 509–512.PubMedGoogle Scholar
  21. 21.
    Moreira-Filho, C. A., Otto, P. G., Mustacchi, Z., Frota-Pessoa, O., and Otto, P. A., 1980, H-Y antigen expression in a case of XX true hermaphroditism, Hum. Genet. 55: 309–314.PubMedCrossRefGoogle Scholar
  22. 22.
    Bernstein, R., Jenkins, T., Dawson, B., Wagner, J., Dewald, G., Koo, G. C., and Wachtel, S. S., 1980, Female phenotype and multiple abnormalities in sibs with a Y chromosome and partial X chromosome duplication: H-Y antigen and Xg blood group findings, J. Med. Genet. 17: 291–300.PubMedCrossRefGoogle Scholar
  23. 23.
    Jones, H. W., Jr., Rary, J. M., Rock, J. A., and Cummings, D., 1979, The role of the H-Y antigen in human sexual development, Johns Hopkins Med. J. 145: 33–43.Google Scholar
  24. 24.
    Turner, G., Daniel, A., and Frost, M., 1980, X-linked mental retardation, macro-orchidism, and the Xq27 fragile site, J. Pediatr. 96: 837–841.PubMedCrossRefGoogle Scholar
  25. 25.
    Sutherland, G. R., and Ashforth, P. L. C., 1979, X-linked mental retardation with macro-orchidism and the fragile site at Xq27 or 28, Hum. Genet. 48: 117–120.PubMedCrossRefGoogle Scholar
  26. 26.
    Forest, M. G., Lecornu, M., and de Peretti, E., 1980, Familial male pseudohermaphroditism due to 17–20-desmolase deficiency. I. In vivo endocrine studies, J. Clin. Endocrinol. Metab. 50: 826–833.Google Scholar
  27. 27.
    Savage, M. O., Preece, M. A., Jeffcoate, S. L., Ransley, P. G., Rumsby, G., Mansfield, M. D., and Williams, D. I., 1980, Familial male pseudohermaphroditism due to deficiency of 5a-reductase, Clin. Endocrinol. 12: 397–406.CrossRefGoogle Scholar
  28. 28.
    Maes, M., Sultan, C., Zerhouni, N., Rothwell, S. W., and Migeon, C. J., 1979, Role of testosterone binding to the androgen receptor in male sexual differentiation of patients with 5a-reductase deficiency, J. Steroid Biochem. 11: 1385–1390.PubMedCrossRefGoogle Scholar
  29. 29.
    Imperato-McGinley, J., Peterson, R. E., Gautier, T., and Sturla, E., 1979, Androgens and the evolution of male-gender identity among male pseudohermaphrodites with 5a-reductase deficiency, N. Engl. J. Med. 300: 1233–1237.PubMedCrossRefGoogle Scholar
  30. 30.
    Forest, M. G., Sizonenko, P. C., Cathiard, A. M., and Bertrand, J., 1974, Hypophyso-gonadal function in humans during the first year of life. I. Evidence for testicular activity in early infancy, J. Clin. Invest. 53: 819–828.PubMedCrossRefGoogle Scholar
  31. 31.
    Gendrel, D., Chaussain, J.-L., Roger, M., and Job, J.-C., 1980, Simultaneous postnatal rise of plasma LH and testosterone in male infants, J. Pediatr. 97: 600–602.PubMedCrossRefGoogle Scholar
  32. 32.
    Oberkotter, L. V., Tenore, A., and Koldovsky, 0., 1980, Sex differences in serum levels of N-acetyl-t3-hexosaminidase in infancy: Correlation of enzyme activity with testosterone levels, Early Hum. Dev. 4: 325–332.PubMedCrossRefGoogle Scholar
  33. 33.
    Pang, S., Levine, L. S., Chow, D., Sagiani, F., Saenger, P., and New, M. I., 1979, Dihydrotestosterone and its relationship to testosterone in infancy and childhood, J. Clin. Endocrinol. Metab. 48: 821–826.PubMedCrossRefGoogle Scholar
  34. 34.
    Forest, M. G., 1979, Pattern of the response of testosterone and its precursors to human chorionic gonadotropin stimulation in relation to age in infants and children, J. Clin. Endocrinol. Metab. 49: 132–137.PubMedCrossRefGoogle Scholar
  35. 35.
    Hammond, G. L., Koivisto, M., Kouvalainen, K., and Vihko, R., 1979, Serum steroids and pituitary hormones in infants with particular reference to testicular activity, J. Clin. Endocrinol. Metab. 49: 40–45.PubMedCrossRefGoogle Scholar
  36. 36.
    Burstein, S., Grumbach, M. M., and Kaplan, S. L., 1979, Early determination of androgen-responsiveness is important in the management of microphallus, Lancet 2: 983–986.PubMedCrossRefGoogle Scholar
  37. 37.
    Hinman, F., Jr., 1980, Microphallus: Distinction between anomalous and endocrine types, J. Urol. 123: 412–415.PubMedGoogle Scholar
  38. 38.
    Ben-Galim, E., Hillman, R. E., and Weldon, V. V., 1980, Topically applied testosterone and phallic growth: Its effect on male children with hypopituitarism and microphallus, Am. J. Dis. Child. 134: 296–298.PubMedGoogle Scholar
  39. 39.
    Danish, R. K., Lee, P. A., Mazur, T., Amrhein, J. A., and Migeon, C. J., 1980, Micropenis. II. Hypogonadotropic hypogonadism, Johns Hopkins Med. J. 146: 177–184.Google Scholar
  40. 40.
    Chaussain, J. L., Gendrel, D., Roger, M., Boudailliez, B., and Job, J. C., 1979, Longitudinal study of plasma testosterone in male pseudohermaphrodites during early infancy, J. Clin. Endocrinol. Metab. 49: 305–306.PubMedCrossRefGoogle Scholar
  41. 41.
    Ojeda, S. R., Andrews, W. W., Advis, J. P., and White, S. S., 1980, Recent advances in the endocrinology of puberty, Endocr. Rev. 1: 228–257.PubMedCrossRefGoogle Scholar
  42. 42.
    Beck, W., and Wuttke, W., 1980, Diurnal variations of plasma luteinizing hormone, follicle-stimulating hormone, and prolactin in boys and girls from birth to puberty, J. Clin. Endocrinol. Metab. 50: 635–639.PubMedCrossRefGoogle Scholar
  43. 43.
    Grumbach, M. M., 1980, The neuroendocrinology of puberty, Hosp. Pract. 15 (3): 51–60.PubMedGoogle Scholar
  44. 44.
    Lee, P. A., and Gisriel, D. L., 1980, Correlation of gonadotropins with unbound testosterone during puberty in males, Horm. Res. 12: 130–136.PubMedCrossRefGoogle Scholar
  45. 45.
    Styne, D. M., Kaplan, S. L., and Grumbach, M. M., 1980, Plasma glycoprotein hormone a-subunit in the neonate and in prepubertal and pubertal children: Effects of luteinizing hormone-releasing hormone, J. Clin. Endocrinol. Metab. 50: 450–455.PubMedCrossRefGoogle Scholar
  46. 46.
    Conte, F. A., Grumbach, M. M., Kaplan, S. L., and Reiter, E. O., 1980, Correlation of luteinizing hormone-releasing factor-induced luteinizing hormone and follicle-stimulating hormone release from infancy to 19 years with the changing pattern of gonadotropin secretion in agonadal patients: Relation to the restraint of puberty, J. Clin. Endocrinol. Metab. 50: 163–168.PubMedCrossRefGoogle Scholar
  47. 47.
    Ducharme, J. R., Catin-Savoie, S., Taché, Y., Bourel, B., and Collu, R., 1979, Sequential hormonal changes and activation of the hypothalamic—pituitary—gonadal axis, J. Steroid Biochem. 11: 563–569.PubMedCrossRefGoogle Scholar
  48. 48.
    Herrera-Justiniano, E., Galvez, M. D., Aznar, A. M., Gomez, S. M. M., Sendon, P. A., Zurita, A. R., Malagon, C. M., and Aznar, R. A., 1979, Changes in the plasma levels of androstenedione, dehydroepiandrosterone and cortisol after stimulation with ACTH and hCG and suppression with dexamethasone during male puberty, Acta Endocrinol. (Copenhagen) 90: 113–121.Google Scholar
  49. 49.
    Pakarinen, A., Hammond, G. L., and Vihko, R., 1979, Serum pregnenolone, progesterone, 17a-hydroxyprogesterone, androstenedione, testosterone, 5a-dihydrotestosterone and androsterone during puberty in boys, Clin. Endocrinol. 11: 465–474.CrossRefGoogle Scholar
  50. 50.
    Odell, W. D., 1979, The physiology of puberty: Disorders of the pubertal process, in: Endocrinology, Volume 3 (L. J. DeGroot, G. F. Cahill, Jr., L. Martini, D. H. Nelson, W. D. Odell, J. T. Potts, Jr., E. Steinberger, and A. I. Winegrad, eds.), pp. 1363–1379, Grune and Stratton, New York.Google Scholar
  51. 51.
    Urban, M. D., Lee, P. A., Gutai, J. P., and Migeon, C. J., 1980, Androgens in pubertal males with Addison’s disease, J. Clin. Endocrinol. Metab. 51: 925–929.PubMedCrossRefGoogle Scholar
  52. 52.
    Sklar, C. A., Kaplan, S. L., and Grumbach, M. M., 1980, Evidence for dissociation between adrenarche and gonadarche: Studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence, J. Clin. Endocrinol. Metab. 51: 548–566.PubMedCrossRefGoogle Scholar
  53. 53.
    Olweus, D., Mattsson, AA., Schalling, D., and Low, H., 1980, Testosterone, aggression, physical, and personality dimensions in normal adolescent males, Psychosom. Med. 42: 253–269.PubMedGoogle Scholar
  54. 54.
    Lucky, A. W., Rich, B. H., Rosenfield, R. L., Fang, V. S., and Roche-Bender, N., 1980, LH bioactivity increases more than immunoreactivity during puberty, J. Pediatr. 97: 205–213.PubMedCrossRefGoogle Scholar
  55. 55.
    Lee, P. A., 1980, Normal ages of pubertal events among American males and females, J. Adolesc. Health Care 1: 26–29.PubMedCrossRefGoogle Scholar
  56. 56.
    Root, A. W., 1980, Hormonal changes in puberty, Pediatr. Ann. 9 (10): 11–27.Google Scholar
  57. 57.
    Harlan, W. R., Grillo, G. P., Cornoni-Huntley, J., and Leaverton, P. E., 1979, Secondary sex characteristics of boys 12 to 17 years of age: The U. S. Health Examination Survey, J. Pediatr. 95: 293–297.PubMedCrossRefGoogle Scholar
  58. 58.
    Daniel, W. A., Jr., 1979, Sex maturity ratings, J. Pediatr. 95: 255–256.PubMedCrossRefGoogle Scholar
  59. 59.
    Round, J. M., 1980, Changes in plasma urate, creatinine, alkaline phosphatase and the 24 hour excretion of hydroxyproline during sexual maturation in adolescents, Ann. Hum. Biol. 7: 83–88.PubMedCrossRefGoogle Scholar
  60. 60.
    Short, R. V., 1976, The evolution of human reproduction, Proc. R. Soc. London Ser. B 195: 3–24.CrossRefGoogle Scholar
  61. 61.
    Adolescent sexuality and adolescent fertility (editorial), Lancet 2: 129–130.Google Scholar
  62. 62.
    Laron, Z., Arad, J., Gurewitz, R., Grunebaum, M., and Dickerman, Z., 1980, Age at first conscious ejaculation: A milestone in male puberty, Helv. Paediatr. Acta 35: 13–20.PubMedGoogle Scholar
  63. 63.
    Raiti, S., Maclaren, N. K., and Akesode, F. A., 1980, Precocious and delayed puberty: Studies of FSH and LH production and metabolism, Acta Endocrinol. (Copenhagen) 94: 475–479.Google Scholar
  64. 64.
    Rosenfeld, R. G., Reitz, R. E., King, A. B., and Hintz, R. L., 1980, Familial precocious puberty associated with isolated elevation of luteinizing hormone, N. Engl. J. Med. 303: 859–862.PubMedCrossRefGoogle Scholar
  65. 65.
    Crowley, W. F., Jr., Comite, F., Vale, W., Rivier, J., Loriaux, D. L., and Cutler, G. B., Jr., 1981, Therapeutic use of pituitary desensitization with a long-acting LHRH agonist: A potential new treatment for idiopathic precocious puberty, J. Clin. Endocrinol. Metab. 52: 370–372.PubMedCrossRefGoogle Scholar
  66. 66.
    Kelch, R. P., Hopwood, N. J., and Marshall, J. C., 1980, Diagnosis of gonadotropin deficiency in adolescents: Limited usefulness of a standard gonadotropin-releasing hormone test in obese boys, J. Pediatr. 97: 820–824.PubMedCrossRefGoogle Scholar
  67. 67, Brook, C. G. D., and Dombey, S., 1979, Induction of puberty: Long-term treatment with high-dose LHRH, Clin. Endocrinol. 11:81–87.Google Scholar
  68. 68.
    Jacobson, R. I., Seyler, L. E., Jr., Tamborlane, W. V., Jr., Gertner, J. M., and Genel, M., 1979, Pulsatile subcutaneous nocturnal administration of GnRH by portable infusion pump in hypogonadotropic hypogonadism: Initiation of gonadotropin responsiveness, J. Clin. Endocrinol. Metab. 49: 652–654.PubMedCrossRefGoogle Scholar
  69. 69.
    Valk, T. W., Corley, K. P., Kelch, R. P., and Marshall, J. C., 1980, Hypogonadotropic hypogonadism: Hormonal responses to low dose pulsatile administration of gonadotropin-releasing hormone, J. Clin. Endocrinol. 51: 730–738.CrossRefGoogle Scholar
  70. 70.
    Crowley, W. F., and McArthur, J. W., 1980, Simulation of the normal menstrual cycle in Kallman’s syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH), J. Clin. Endocrinol. Metab. 51: 173–175.PubMedCrossRefGoogle Scholar
  71. 71.
    McArthur, J. W., 1980, Induction of puberty in hypogonadotropic males: Use of low dose pulsatile luteinizing hormone releasing hormone (LHRH) administration, Abstract No. 743, 62nd Annual Meeting of the Endocrine Society.Google Scholar
  72. 72.
    de Lange, W. E., Snoep, M. C., and Doorenbos, H., 1979, The effect of short-term testosterone treatment in boys with delayed puberty, Acta Endocrinol. (Copenhagen) 91: 177–183.Google Scholar
  73. 73.
    Imperato-McGinley, J., Peterson, R. E., Gautier, T., and Sturla, E., 1979, Male pseudohermaphroditism secondary to 5a-reductase deficiency—A model for the role of androgens in both the development of the male phenotype and the evolution of a male gender identity, J. Steroid Biochem. 11: 637–645.PubMedCrossRefGoogle Scholar
  74. 74.
    Imperato-McGinley, J., Peterson, R. E., Leshin, M., Griffin, J. E., Cooper, G., Draghi, S., Berenyi, M., and Wilson, J. D., 1980, Steroid 5a-reductasedeficiency in a 65-year-old male pseudohermaphrodite: The natural history, ultrastructure of the testes, and evidence for inherited enzyme heterogeneity, J. Clin. Endocrinol. Metab. 50: 15–22.Google Scholar
  75. 75.
    Imperato-McGinley, J., Peterson, R. E., Stoller, R., and Goodwin, W. E., 1979, Male pseudohermaphroditism secondary to 1713-hydroxysteroid dehydrogenase deficiency: Gender role change with puberty, J. Clin. Endocrinol. Metab. 49: 391–395.PubMedCrossRefGoogle Scholar
  76. 76.
    Foucault, M. (ed.), 1980, Herculine Barbin: The Recently Discovered Memoirs of a Nineteenth-Century French Hermaphrodite, Pantheon Books, New York.Google Scholar
  77. 77.
    Wilson, J. D., Aiman, J., and MacDonald, P. C., 1980, The pathogenesis of gynecomastia, Adv. Intern. Med. 25: 1–32.PubMedGoogle Scholar
  78. 78.
    Large, D. M., and Anderson, D. C., 1979, Twenty-four hour profiles of circulating androgens and oestrogens in male puberty with and without gynaecomastia, Clin. Endocrinol. 11: 505–521.CrossRefGoogle Scholar
  79. 79.
    Large, D. M., Anderson, D. C., and Laing, I., 1980, Twenty-four hour profiles of serum prolactin during male puberty with and without gynaecomastia, Clin. Endocrinol. 12: 293–302.CrossRefGoogle Scholar
  80. 80.
    Marynick, S. P., Nisula, B. C., Pita, J. C., Jr., and Loriaux, D. L., 1980, Persistent pubertal macromastia, J. Clin. Endocrinol. Metab. 50: 128–130.PubMedCrossRefGoogle Scholar
  81. 81.
    LeRoith, D., Sobel, R., and Glick, S. M., 1980, The effect of clomiphene citrate on pubertal gynaecomastia, Acta Endocrinol. (Copenhagen) 95: 177–180.Google Scholar
  82. 82.
    Bardin, C. W., 1979, The neuroendocrinology of male reproduction, Hosp. Pract. 14 (12): 65–75.PubMedGoogle Scholar
  83. 83.
    Pinto, H., Wajchenberg, B. L., Lima, F. B., Goldman, J., Comaru-Schally, A. M., and Schally, A. V., 1979, Evaluation of the gonadotrophic responsiveness of the pituitary to acute and prolonged administration of LH/FHreleasing hormone (LH-RH) in normal females and males, Acta Endocrinol. (Copenhagen) 91: 1–13.Google Scholar
  84. 84.
    Bergquist, C., Nillius, S. J., Bergh, T., Skarin, G., and Wide, L., 1979, Inhibitory effects on gonadotrophin secretion and gonadal function in men during chronic treatment with a potent stimulatory luteinizing hormone-releasing hormone analogue, Acta Endocrinol. (Copenhagen) 91: 601–608.Google Scholar
  85. 85.
    Catt, K. J., Baukal, A. J., Davies, T. F., and Dafau, M. L., 1979, Luteinizing hormone-releasing hormone-induced regulation of gonadotropin and prolactin receptors in the rat testis, Endocrinology 104: 17–25.PubMedCrossRefGoogle Scholar
  86. 86.
    Clayton, R. N., Katikineni, M., Chan, V., Dufau, M. L., and Catt, K. J., 1980, Direct inhibition of testicular function by gonadotropin-releasing hormone: Mediation by specific gonadotropin-releasing hormone receptors in interstitial cells, Proc. Natl. Acad. Sci. USA 77: 4459–4463.PubMedCrossRefGoogle Scholar
  87. 87.
    Bourne, G. A., Regiani, S., Payne, A. H., and Marshall, J. C., 1980, Testicular GnRH receptors-Characterization and localization on interstitial tissue, J. Clin. Endocrinol. Metab. 51: 407–409.PubMedCrossRefGoogle Scholar
  88. 88.
    Sharpe, R. M., and Fraser, H. M., 1980, HCG stimulation of testicular LHRH-like activity, Nature (London) 287: 642–643.CrossRefGoogle Scholar
  89. 89.
    Lipsett, M. B., 1979, The role of testosterone and other hormones in regulation of LH, J. Steroid Biochem. 11: 659–661.PubMedCrossRefGoogle Scholar
  90. 90.
    Naftolin, F., Ryan, K. J., Davies, I. J., Reddy, I. I., Flores, F., Petro, Z., Kulin, M., White, R. J., Takaoka, Y., and Wolin, L., 1975, The formation of estrogens by central neuroendocrine tissues, Recent Prog. Horm. Res. 31: 295–315.PubMedGoogle Scholar
  91. 91.
    Marynick, S. P., Loriaux, D. L., Sherins, R. J., Pita, J. C., Jr., and Lipsett, M. B., 1979, Evidence that testosterone can suppress pituitary gonadotropin secretion independently of peripheral aromatization, J. Clin. Endocrinol. Metab. 49: 396–398.PubMedCrossRefGoogle Scholar
  92. 92.
    Lacroix, A., McKenna, T. J., and Rabinowitz, D., 1979, Sex steroid modulation of gonadotropins in normal men and in androgen insensitivity syndrome, J. Clin. Endocrinol. Metab. 48: 235–240.PubMedCrossRefGoogle Scholar
  93. 93.
    Martini, L., Celotti, F., and Serio, M., 1979, 5a-reductase deficiency in humans: Support to the theory that 5a-reduction of testosterone is an essential step in the control of LH secretion [letter], J. Endocrinol. Invest. 2: 463.Google Scholar
  94. 94.
    Winters, S. J., Janick, J. J., Loriaux, D. L., and Sherins, R. J., 1979, Studies on the role of sex steroids in the feedback control of gonadotropin concentrations in men. II. Use of the estrogen antagonist, clomiphene citrate, J. Clin. Endocrinol. Metab. 48: 222–227.PubMedCrossRefGoogle Scholar
  95. 95.
    Schaison, G., Renoir, M., Lagoguey, M., and Mowszowicz, I., 1980, On the role of dihydrotestosterone in regulating luteinizing hormone secretion in man, J. Clin. Endocrinol. Metab. 51: 1133–1137.PubMedCrossRefGoogle Scholar
  96. 96.
    Caminos-Torres, R., Ma, L., and Snyder, P. J., 1977, Testosterone-induced inhibition of the LH and FSH responses to gonadotropin-releasing hormone occurs slowly, J. Clin. Endocrinol. Metab. 44: 1142–1153.PubMedCrossRefGoogle Scholar
  97. 97.
    Axelrod, L., Neer, R. M., and Kliman, B., 1979, Hypogonadism in a male with immunologically active, biologically inactive luteinizing hormone: An exception to a venerable rule, J. Clin. Endocrinol. Metab. 48: 279–287.PubMedCrossRefGoogle Scholar
  98. 98.
    Knobil, E., Plant, T. M., Wildt, L., Belchetz, P. E., and Marshall, G., 1980, Control of the rhesus monkey menstrual cycle: Permissive role of hypothalamic gonadotropin-releasing hormone, Science 207: 1371–1373.PubMedGoogle Scholar
  99. 99.
    Wildt, L., Marshall, G., and Knobil, E., 1980, Experimental induction of puberty in the infantile female rhesus monkey, Science 207: 1373–1375.PubMedGoogle Scholar
  100. 100.
    Barbarino, A., and De Marinis, L., 1980, Estrogen induction of luteinizing hormone release in castrated adult human males, J. Clin. Endocrinol. Metab. 51: 280–286.PubMedCrossRefGoogle Scholar
  101. 101.
    Seyler, L. E., Jr., Canalis, E., Spare, S., and Reichlin, S., 1978, Abnormal gonadotropin secretory responses to LRH in transsexual women after diethylstilbestrol priming, J. Clin. Endocrinol. Metab. 47: 176–183.PubMedCrossRefGoogle Scholar
  102. 102.
    Preslock, J. P., 1980, A review of in vitro testicular steroidogenesis in rodents, monkeys and humans, J. Steroid Biochem. 13: 965–975.PubMedCrossRefGoogle Scholar
  103. 103.
    Preslock, J. P., 1980, Steroidogenesis in the mammalian testis, Endocr. Rev. 1: 132–139.CrossRefGoogle Scholar
  104. 104.
    Catt, K. J., Harwood, J. P., Clayton, R. N., Davies, T. F., Chan, V., Katikineni, M., Nozu, K., and Dufau, M. L., 1980, Regulation of peptide hormone receptors and gonadal steroidogenesis, Recent Prog. Horm. Res. 36: 557–622.PubMedGoogle Scholar
  105. 105.
    Smals, A. G. H., Pieters, G. F. F. M., Lozekoot, D. C., Benraad, T. J., and Kloppenborg, P. W. C., 1980, Dissociated responses of plasma testosterone and 17-hydroxyprogesterone to single or repeated human chorionic gonadotropin administration in normal men, J. Clin. Endocrinol. Metab. 50: 190–193.PubMedCrossRefGoogle Scholar
  106. 106.
    Smals, A. G. H., Pieters, G. F. F. M., Drayer, J. I. M., Boers, G. H. J., Benraad, T. J., and Kloppenborg, P. W. C., 1980, Tamoxifen suppresses gonadotropin-induced 17a-hydroxyprogesterone accumulation in normal men, J. Clin. Endocrinol. Metab. 51: 1026–1029.PubMedCrossRefGoogle Scholar
  107. 107.
    Glass, A. R., and Vigersky, R. A., 1980, Correlation of acute and chronic increases in serum gonadal steroid levels after administration of human chorionic gonadotropin, Fertil. Steril. 34: 41–45.PubMedGoogle Scholar
  108. 108.
    Glass, A. R., and Vigersky, R. A., 1980, Resensitization of testosterone production in men after human chorionic gonadotropin-induced desensitization, J. Clin. Endocrinol. Metab. 51: 1395–1400.PubMedCrossRefGoogle Scholar
  109. 109.
    Padrón, R. S., Wischusen, J., Hudson, B., Burger, H. G., and de Kretser, D. M., 1980, Prolonged biphasic response of plasma testosterone to single intramuscular injections of human chorionic gonadotropin, J. Clin. Endocrinol. Metab. 50: 1100–1104.Google Scholar
  110. 110.
    Martikainen, H., Huhtaniemi, I., and Vihko, R., 1980, Response of peripheral serum sex steroids and some of their precursors to a single injection of hCG in adult men, Clin. Endocrinol. 13: 157–166.CrossRefGoogle Scholar
  111. 111.
    Wang, C., Rebar, R. W., Hopper, B. R., and Yen, S. S. C., 1980, Functional studies of the luteinizing hormone—Leydig cell—androgen axis: Exaggerated response in C-18 and C-21 testicular steroids to various modes of luteinizing hormone stimulation,/ Clin. Endocrinol. Metab. 51: 201–208.CrossRefGoogle Scholar
  112. 112.
    Davies, T. F., Hodgen, G. D., Dufau, M. L., and Catt, K.J., 1979, Regulation of primate testicular luteinizing hormone receptors and steroidogenesis, J. Clin. Invest. 64: 1070–1073.PubMedCrossRefGoogle Scholar
  113. 113.
    Leinonen, P., Hammond, G. L., and Vihko, R., 1980, Testosterone and some its precursors and metabolites in the human epididymis, J. Clin. Endocrinol. Metab. 51: 423–428.PubMedCrossRefGoogle Scholar
  114. 114.
    Kley, H. K., Deselaers, T., Peerenboom, H., and Krüskemper, H. L., 1980, Enhanced conversion of androstenedione to estrogens in obese males, J. Clin. Endocrinol. Metab. 51: 1128–1132.PubMedCrossRefGoogle Scholar
  115. 115.
    MacLeod, J., and Wang, Y., 1979, Male fertility potential in terms of semen quality: A review of the past, a study of the present, Fertil. Steril. 31: 103–116.PubMedGoogle Scholar
  116. 116.
    David, G., Jouannet, P., Martin-Boyce, A., Spira, A., and Schwartz, D., 1979, Sperm counts in fertile and infertile men, Fertil. Steril. 31: 453–455.PubMedGoogle Scholar
  117. 117.
    Smith, K. D., and Rodriguez-Rigau, L. J., 1979, Laboratory evaluation of testicular function, in: Endocrinology, Volume 3 (L. J. DeGroot, G. F. Cahill, Jr., L. Martini, D. H. Nelson, W. D. Odell, J. T. Potts, Jr., E. Steinberger, and A. I. Winegrad, eds.), pp. 1539–1547, Grune and Stratton, New York.Google Scholar
  118. 118.
    van Dop, P. A., Scholtmeijer, R. J., Kruver, P. H. J., Baak, J. P. A., Oort, J., and Stolte, L. A. M., 1980, A quantitative structural model of the testis of fertile males with normal sperm counts, Int. J. Androl. 3: 153–169.PubMedCrossRefGoogle Scholar
  119. 119.
    van Dop, P. A., Kruver, P. H. J., Scholtmeijer, R. J., Baak, J. P. A., Oort, J., and Stolte, L. A. M., 1980, Correlations between the quantitative mor-phology of the human testis and sperm production: The testis of healthy men with normal sperm counts, Int. J. Androl. 3: 170–176.PubMedCrossRefGoogle Scholar
  120. 120.
    Steinberger, E., 1979, Hormonal control of spermatogenesis, in: Endocrinology, Volume 3 (L. J. DeGroot, G. F. Cahill, Jr., L. Martini, D. H. Nelson, W. D. Odell, J. T. Potts, Jr., E. Steinberger, and A. I. Winegrad, eds.), pp. 1535–1538, Grune and Stratton, New York.Google Scholar
  121. 121.
    Means, A. R., Dedman, J. R., Tindall, D. J., and Welsh, M. J., 1978, Hormonal regulation of Sertoli cells, Int. J. Androl. Suppl. 2: 403–423.CrossRefGoogle Scholar
  122. 122.
    Ritzen, E. M., Hansson, V., and French, F. S., 1978, Androgen action on spermatogenesis, Int. J. Androl. Suppl. 1: 108–115.CrossRefGoogle Scholar
  123. 123.
    Karim, S. M. M., and Hillier, K., 1979, Prostaglandins in the control of animal and human reproduction, Br. Med. Bull. 35: 173–180.PubMedGoogle Scholar
  124. 124.
    Harman, S. M., and Tsitouras, P. D., 1980, Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin, J. Clin. Endocrinol. Metab. 51: 35–40.PubMedCrossRefGoogle Scholar
  125. 125.
    Sparrow, D., Bosse, R., and Rowe, J. W., 1980, The influence of age, alcohol consumption, and body build on gonadal function in men, J. Clin. Endocrinol. Metab. 51: 508–519.PubMedCrossRefGoogle Scholar
  126. 126.
    Sköldefors, H., Carlström, K., and Eneroth, P., 1978, Influence of aging upon the serum hormone levels in the male, Int. J. Androl. 1: 306–316.CrossRefGoogle Scholar
  127. 127.
    Serio, M., Gonnelli, P., Borrelli, D., Pampaloni, A., Fiorelli, G., Calabresi, E., Forti, G., Pazzagli, M., Mannelli, M., Baroni, A., Giannotti, P., and Giusti, G., 1978, Human testicular secretion with increasing age, J. Steroid Biochem. 11: 893–897.CrossRefGoogle Scholar
  128. 128.
    Kaler, L. W., and Neaves, W. B., 1978, Attrition of the human Leydig cell population with advancing age, Anat. Rec. 192: 513–518.PubMedCrossRefGoogle Scholar
  129. 129.
    Smith, R., Donald, R. A., Espiner, E. A., Stronach, S. G., and Edwards, I. A., 1979, Normal adults and subjects with hypogonadotropic hypogonadism respond differently to D-Ser(TBU)6-LH-RH-EA10, J. Clin. Endocrinol. Metab. 48: 167–170.PubMedCrossRefGoogle Scholar
  130. 130.
    Smith, R., Donald, R. A., Espiner, E. A., and Stronach, S., 1979, The effects of prolonged administration of n-Ser(TBU)6-LH-RH-EA10 (HOE 766) in subjects with hypogonadotrophic hypogonadism, Clin. Endocrinol. 11: 553–559.CrossRefGoogle Scholar
  131. 131.
    Heath, M., Scanlon, M. F., Mora, B., Snow, M. H., Gomez-Pan, A., Watson, M. J., Mulligan, F., and Hall, R., 1979, The pituitary—gonadal response to the gonadotrophin releasing hormone analogue n-Ser(TBU)6-des Gly10LHRH-ethylamide in normal men, Clin. Endocrinol. 10: 297–303.Google Scholar
  132. 132.
    Snyder, P.J., Rudenstein, R. S., Gardner, D. F., and Rothman, J. G., 1979, Repetitive infusion of gonadotropin-releasing hormone distinguishes hypothalamic from pituitary hypogonadism, J. Clin. Endocrinol. Metab. 48: 864–868.PubMedCrossRefGoogle Scholar
  133. 133.
    Kletzky, O. A., Costin, G., Marrs, R. P., Bernstein, G., March, C. M., and Mishell, D. R., Jr., 1979, Gonadotropin insufficiency in patients with thalassemia major, J. Clin. Endocrinol. Metab. 48: 901–905.PubMedCrossRefGoogle Scholar
  134. 134.
    Smals, A. G. H., Pieters, G. F. F. M., Kloppenborg, P. W. C., Lozekoot, D. C., and Benraad, T. J., 1980, Lack of a biphasic steroid response to single human chorionic gonadotropin administration in patients with isolated gonadotropin deficiency, J. Clin. Endocrinol. Metab. 50: 879–881.PubMedCrossRefGoogle Scholar
  135. 135.
    Spitz, I. M., Zylber, E., Cohen, H., Almaliach, U., and Leroith, D., 1979, Impaired prolactin response to thyrotropin-releasing hormone in isolated gonadotropin deficiency and exaggerated response in primary testicular failure, J. Clin. Endocrinol. Metab. 48: 941–945.PubMedCrossRefGoogle Scholar
  136. 136.
    Bartrinos, M. L., Panitsa-Faflia, C., Pitoulis, S., and Petraki, N., 1980, Pituitary–gonadal function in three relatives presenting with Kallmann’s syndrome, Horm. Res. 12: 79–86.CrossRefGoogle Scholar
  137. 137.
    Rogol, A. D., Mittal, K. K., White, B. J., McGinness, M. H., Lieblich, J. M., and Rosen, S. W., 1980, HLA-compatible paternity in two “fertile eunuchs” with congenital hypogonadotropic hypogonadism and anosmia (the Kallmann syndrome), J. Clin. Endocrinol. Metab. 51: 275–279.PubMedCrossRefGoogle Scholar
  138. 138.
    Barenetsky, N. G., and Carolson, H. E., 1980, Persistence of spermatogenesis in hypogonadotropic hypogonadism treated with testosterone, Fertil. Steril. 34: 477–482.Google Scholar
  139. 139.
    Nistal, M., and Paniagua, R., 1979, Leydig cell differentiation induced by stimulation with HCG and HMG in two patients affected with hypogonadotropic hypogonadism, Andrologia 11: 211–222.PubMedCrossRefGoogle Scholar
  140. 140.
    Davidson, J. M., Camargo, C. A., and Smith, E. R., 1979, Effects of androgen on sexual behavior in hypogonadal men, J. Clin. Endocrinol. Metab. 48: 955–958.PubMedCrossRefGoogle Scholar
  141. 141.
    Snyder, P. J., and Lawrence, D. A., 1980, Treatment of male hypogonadism with testosterone enanthate, J. Clin. Endocrinol. Metab. 51: 1335–1339.PubMedCrossRefGoogle Scholar
  142. 142.
    Snyder, P. J., Bigdeli, H., Gardner, D. F., Mihailovic, V., Rudenstein, R. S., Sterling, F. H., and Utiger, R. D., 1979, Gonadal function in fifty men with untreated pituitary adenomas, J. Clin. Endocrinol. Metab. 48: 309–314.PubMedCrossRefGoogle Scholar
  143. 143.
    Snyder, P. J., Muzyka, R., Johnson, J., and Utiger, R. D., 1980, Thyrotropin-releasing hormone provokes abnormal follicle-stimulating hormone (FSH) and luteinizing hormone responses in men who have pituitary adenomas and FSH hypersecretion, J. Clin. Endocrinol. Metab. 51: 744–749.PubMedCrossRefGoogle Scholar
  144. 144.
    Schnakenburg, K. v., Bidlingmaier, F., Engelhardt, D., Butenandt, O., and Knorr, D., 1980, 17-Ketosteroid reductase deficiency—Plasma steroids and incubation studies with testicular tissue, Acta Endocrinol. (Copenhagen) 94: 397–403.Google Scholar
  145. 145.
    Maes, M., Lee, P. A., Jeffs, R. D., Sultan, C., and Migeon, C. J., 1980, Phenotypic variation in a family with partial androgen insensitivity syndrome, Am. J. Dis. Child. 134: 470–473.PubMedGoogle Scholar
  146. 146.
    Larrea, F., Benavides, G., Scaglia, H., Kofman-Alfaro, S., Ferrusca, E., Medina, M., and Pérez-Palactios, G., 1978, Gynecomastia as a familial incomplete male pseudohermaphroditism type 1: A limited androgen resistance syndrome, J. Clin. Endocrinol. Metab. 46: 961–970.PubMedCrossRefGoogle Scholar
  147. 147.
    George, F. W., and Wilson, J. D., 1980, Pathogenesis of the henny feathering trait in the Sebright bantam chicken: Increased conversion of androgen to estrogen, J. Clin. Invest. 66: 57–65.PubMedCrossRefGoogle Scholar
  148. 148.
    Albright, F., Burnett, C. H., Smith, P. H., and Parson, W., 1942, Pseu-dohypoparathyroidism-An example of `Seabright-Bantam syndrome,’ Endocrinology 30: 922–932.Google Scholar
  149. 149.
    Boisen, E., 1979, Testicular size and shape of 47,XYY and 47,XXY men in a double-blind, double-matched population survey, Am. J. Hum. Genet. 31: 697–703.PubMedGoogle Scholar
  150. 150.
    Smals, A. G. H., Kloppenborg, P. W. C., Pieters, G. F. F. M., Hoefnagels, W. H. L., Lequin, R. M., and Benraad, T. J., 1979, Modulation of the gonadotropin response to constant luteinizing hormone-releasing hormone infusion by acute and chronic testosterone administration in Klinefelter’s syndrome, J. Clin. Endocrinol. Metab. 48: 148–152.PubMedCrossRefGoogle Scholar
  151. 151.
    Gabrilove, J. L., Freiberg, E. K., and Nicolis, G. L., 1980, Testicular function in Klinefelter’s syndrome, J. Urol. 124: 825–826.PubMedGoogle Scholar
  152. 152.
    Wieland, R. G., Zorn, E. M., and Johnson, M. W., 1980, Elevated testosterone-binding globulin in Klinefelter’s syndrome, J. Clin. Endocrinol. Me-tab. 51: 1199–1200.CrossRefGoogle Scholar
  153. 153.
    Barbarino, A., De Marinis, L., LaFuenti, G., Muscatello, P., and Matteucci, B. R., 1979, Presence of positive feedback between oestrogen and LH in patients with Klinefelter’s syndrome, and Sertoli-cell-only syndrome, Clin. Endocrinol. 10: 235–242.CrossRefGoogle Scholar
  154. 154.
    Samaan, N. A., Stepanas, A. V., Danziger, J., and Trujillo, J., 1979, Reactive pituitary abnormalities in patients with Klinefelter’s and Turner’s syndromes, Arch. Intern. Med. 139: 198–201.PubMedCrossRefGoogle Scholar
  155. 155.
    Gabrilove, J. L., Freiberg, E. K., Thornton, J. C., and Nicolis, G. L., 1979, Effect of age on testicular function in patients with Klinefelter’s syndrome, Clin. Endocrinol. 11: 343–347.CrossRefGoogle Scholar
  156. 156.
    Ellison, H. S., Scheuer, S. A., and Eichner, E. R., 1980, Metastatic breast carcinoma with positive estrogen and progesterone receptors in a man with Klinefelter’s syndrome, South. Med. J. 73: 1393–1396.PubMedCrossRefGoogle Scholar
  157. 157.
    Sogge, M. R., McDonald, S. D., and Cofold, P. B., 1979, The malignant potential of the dysgenetic germ cell in Klinefelter’s syndrome, Am. J. Med. 66: 515–518.PubMedCrossRefGoogle Scholar
  158. 158.
    Vaze, A. Y., Thakur, A. N., and Sheth, A. R., 1979, Development of radioimmunoassay for human seminal plasma inhibin, J. Reprod. Fertil. Suppl. 26: 135–146.PubMedGoogle Scholar
  159. 159.
    Asch, R. H., Vaze, A. Y., Thakur, A. N., and Sheth, A. R., 1980, Concentrations of immunoreactive inhibin in seminal plasma and serum from normospermic, oligospermic, vasectomized, Klinefelter’s syndrome, and Sertoli-cell-only syndrome subjects, J. Androl. 1: 252–254.Google Scholar
  160. 160.
    Scott, R. S., and Burger, H. G., 1980, Inhibin is absent from azoospermic semen of infertile men, Nature (London) 285: 246–247.CrossRefGoogle Scholar
  161. 161.
    Editorial, 1979, Recognisable patterns of male infertility, Br. Med. J. 2: 1169–1170.CrossRefGoogle Scholar
  162. 162.
    Haas, G. G., Jr., Cines, D. B., and Schreiber, A. D., 1980, Immunologic infertility: Identification of patients with antisperm antibody, N. Engl. J. Med. 303: 722–727.PubMedCrossRefGoogle Scholar
  163. 163.
    Troen, P., and Oshima, H., 1980, The male factor [editorial], N. Engl. J. Med. 303: 751–752.PubMedCrossRefGoogle Scholar
  164. 164.
    Sturgess, J. M., Chao, J., Wong, J., Aspin, N., and Turner, J. A. P., 1979, Cilia with defective radial spokes: A cause of human respiratory disease, N. Engl. J. Med. 300: 53–56.PubMedCrossRefGoogle Scholar
  165. 165.
    Editorial, 1980, Flagellating cilia, Lancet 1: 346–347.Google Scholar
  166. 166.
    Marmor, D., Taillemite, J.-L., Van den Akker, J., Portnoi, M.-F., Le Porrier, N., Joye, N., Delafontaine, D., and Roux, C., 1980, Semen analysis in subfertile balanced-translocation carriers, Fertil. Steril. 34: 496–502.PubMedGoogle Scholar
  167. 167.
    Glass, R. I., Lyness, R. N., Mengle, D. C., Powell, K. E., and Kahn, E., 1979, Sperm count depression in pesticide applicators exposed to dibromochloropropane, Am. J. Epidemiol. 109: 346–351.PubMedGoogle Scholar
  168. 168.
    Vermeulen, A., Comhaire, F., and Vendeweghe, M., 1979, Hormonal exploration of male infertility, Acta Eur. Fertil. 10: 105–112.PubMedGoogle Scholar
  169. 169.
    Rosemberg, E., 1978, Importance of endocrine evaluation in the diagnosis and treatment of disorders of the male reproductive tract, Int. J. Androl. Suppl. 1: 21–35.CrossRefGoogle Scholar
  170. 170.
    Glass, A. R., and Vigersky, R. A., 1980, Leydig cell function in idiopathic oligospermia, Fertil. Steril. 34: 144–148.PubMedGoogle Scholar
  171. 171.
    Rodriguez-Raigau, L. J., Smith, K. D., and Steinberger, E., 1980, A possible relation between elevated FSH levels and Leydig cell dysfunction in azoospermic and oligospermic men, J. Androl. 1: 127–132.Google Scholar
  172. 172.
    Segal, S., Yaffe, H., Laufer, N., and Ben-David, M., 1979, Male hyperprolactinemia: Effects on fertility, Fertil. Steril. 32: 556–561.PubMedGoogle Scholar
  173. 173.
    Pont, A., Shelton, R., Odell, W. D., and Wilson, C. B., 1979, Prolactinsecreting tumors in men: Surgical care, Ann. Intern. Med. 91: 211–213.PubMedGoogle Scholar
  174. 174.
    Jequier, A. M., Crich, J. C., and Ansell, I. D., 1979, Clinical findings and testicular histology in three hyperprolactinemic infertile men, Fertil. Steril. 31: 525–530.PubMedGoogle Scholar
  175. 175.
    Spark, R. F., and Dickstein, G., 1979, Bromocriptine and endocrine disorders, Ann. Intern. Med. 90: 949–956.PubMedGoogle Scholar
  176. 176.
    Hovatta, O., Koskimies, A. I., Ranta, T., Stenman, U.-H., and Seppälä, M., 1979, Bromocriptine treatment of oligospermia: A double blind study, Clin. Endocrinol. 11: 377–382.CrossRefGoogle Scholar
  177. 177.
    Glatthaar, C., Donald, R. A., Smith, R., and McRae, C. U., 1980, Pituitary function in normoprolactinaemic infertile men receiving bromocriptine, Clin. Endocrinol. 13: 455–459.CrossRefGoogle Scholar
  178. 178.
    Charny, C. W., 1979, Clomiphene therapy in male infertility: A negative report, Fertil. Steril. 32: 551–555.PubMedGoogle Scholar
  179. 179.
    Allag, I. S., and Alexander, N. J., 1979, Clomiphene citrate therapy for male infertility, Urology 14: 500–503.PubMedCrossRefGoogle Scholar
  180. 180.
    Paulson, D. F., Hammond, C. B., White, R., d., and Wiebe, R. H., 1977, Clomiphene citrate: Pharmacologic treatment of hypofertile male, Urology 9: 419–421.Google Scholar
  181. 181.
    Schill, W.-B., 1979, Recent progress in pharmacological therapy of male subfertility—A review, Andrologia 112: 77–107.Google Scholar
  182. 182.
    Lunenfeld, B., Olchovsky, D., Tadir, Y., and Glezerman, M., 1979, Treatment of male infertility with human gonadotrophins: Selection of cases, management and results, Andrologia 11: 331–336.PubMedCrossRefGoogle Scholar
  183. 183.
    Chehval, M. J., and Mehan, D. J., 1979, Chorionic gonadotropins in the treatment of the subfertile male, Fertil. Steril. 31: 666–668.PubMedGoogle Scholar
  184. 184.
    Morley, J. E., and Melmed, S., 1979, Gonadal dysfunction in systemic disorders, Metabolism 28: 1051–1073.PubMedCrossRefGoogle Scholar
  185. 185.
    Federman, D. D. (ed.), 1980, Endocrine Manifestations of Systemic Disease, Clin. Endocrinol. Metab. 8.Google Scholar
  186. 186.
    Bommer, J., del Pozo, E., Ritz, E., and Bommer, G., 1979, Improved sexual function in male haemodialysis patients on bromocriptine, Lancet 2: 496–497.PubMedCrossRefGoogle Scholar
  187. 187.
    Gómez, F., De La Cueva, R., Wauters, J.-P., and Lemarchand-Béraud, T., 1980, Endocrine abnormalities in patients undergoing long-term hemodialysis: The role of prolactin, Am. J. Med. 68: 522–530.PubMedCrossRefGoogle Scholar
  188. 188.
    Gura, V., Weizman, A., Maoz, B., Zevin, D., and Ben-David, M., 1980, Hyperprolactinemia: A possible cause of sexual impotence in male patients undergoing chronic hemodialysis, Nephron 26: 53–54.PubMedCrossRefGoogle Scholar
  189. 189.
    Abel, E. L., 1980, A review of alcohol’s effects on sex and reproduction, Drug Alcohol Depend. 5: 321–332.PubMedCrossRefGoogle Scholar
  190. 190.
    van Thiel, D. H., 1979, Feminization of chronic alcoholic men: A formulation, Yale J. Biol. Med. 52: 219–225.PubMedGoogle Scholar
  191. 191.
    Morley, J. E., Distiller, L. A., Lissoos, I., Lipschitz, R., Kay, G., Searle, D. L., and Katz, M., 1979, Testicular function in patients with spinal cord damage, Horm. Metab. Res. 11: 679–682.PubMedCrossRefGoogle Scholar
  192. 192.
    Hayes, P. J., Krishnan, K. R., Diver, M. J., Hipkin, L. J., and Davis, J. C., 1979, Testicular endocrine function in paraplegic men, Clin. Endocrinol. 11: 549–552.CrossRefGoogle Scholar
  193. 193.
    McKenna, T. J., Lorber, D., Lacroix, A., and Rabin, D., 1979, Testicular activity in Cushing’s disease, Acta Endocrinol. (Copenhagen) 91: 501–510.Google Scholar
  194. 194.
    Toone, B. K., Wheeler, M., and Fenwick, P. B. C., 1980, Sex hormone changes in male epileptics, Clin. Endocrinol. 12: 391–395.CrossRefGoogle Scholar
  195. 195.
    Sherins, R. J., Olweny, C. L. M., and Ziegler, J. L., 1978, Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin’s disease, N. Engl. J. Med. 299: 12–16.PubMedCrossRefGoogle Scholar
  196. 196.
    Glass, A. R., and Berenberg, J., 1979, Gynecomastia after chemotherapy for lymphoma, Arch. Intern. Med. 139: 1048–1049.PubMedCrossRefGoogle Scholar
  197. 197.
    Friedman, N. M., and Plymate, S. R., 1980, Leydig cell dysfunction and gynaecomastia in adult males treated with alkylating agents, Clin. Endocrinol. 12: 553–556.CrossRefGoogle Scholar
  198. 198.
    Fraley, E. E., Lange, P. H., and Kennedy, B. J., 1979, Germ-cell testicular cancer in adults, N. Engl. J. Med. 301: 1370–1377.PubMedCrossRefGoogle Scholar
  199. 199.
    National Institutes of Health Conference, 1979, Testicular germ-cell neoplasms: Recent advances in diagnosis and therapy, Ann. Intern. Med. 90: 373–385.Google Scholar
  200. 200.
    Catalona, W. J., Vaitukaitis, J. L., and Fair, W. R., 1979, Falsely positive specific human chorionic gonadotropin assays in patients with testicular tumors: Conversion to negative with testosterone administration, J. Urol. 122: 126–128.PubMedGoogle Scholar
  201. 201.
    Lipsett, M. B., 1979, Functional tumors of the testis, in: Endocrinology, Volume 3 (L.J. DeGroot, G.F. Cahill, Jr., L. Martini, D.H. Nelson, W.D. Odell, J.T. Potts, Jr., E. Steinberger, and A.I. Winegrad, eds.), pp. 1573–1576, Grune and Stratton, New York.Google Scholar
  202. 202.
    Damjanov, I., Katz, S. M., and Jewett, M. A. S., 1979, Leydig cell tumors of the testis, Ann. Clin. Lab. Sci. 9: 157–163.PubMedGoogle Scholar
  203. 203.
    Caldamone, A. A., Altebarmakian, V., Frank, I. N., and Linke, C. A., 1979, Leydig cell tumor of testis, Urology 14: 39–43.PubMedCrossRefGoogle Scholar
  204. 204.
    Klippel, K. F., Jonas, U., Hohenfellner, R., and Walther, D., 1979, Interstitial cell tumor of testis: A delicate problem, Urology 14: 79–82.PubMedCrossRefGoogle Scholar
  205. 205.
    Perez, C., Novoa, J., Alcaniz, J., Salto, L., and Barcelo, B., 1980, Leydig cell tumour of the testis with gynaecomastia and elevated oestrogen, progesterone and prolactin levels: Case report, Clin. Endocrinol. 13: 409–412.CrossRefGoogle Scholar
  206. 206.
    van Thiel, D. H., Gavaler, J. S., Smith, W. I., Jr., and Paul, G., 1979, Hypothalamic—pituitary—gonadal dysfunction in men using cimetidine, N. Engl. J. Med. 300: 1012–1015.PubMedCrossRefGoogle Scholar
  207. 207.
    Temple, R. J., Jones, J. K., and Crout, J. R., 1979, Adverse effects of newly marketed drugs [editorial], N. Engl. J. Med. 300: 1046–1047.PubMedCrossRefGoogle Scholar
  208. 208.
    Huffman, D. H., Kampmann, J. P., Hignite, C. E., and Azarnoff, D. L., 1978, Gynecomastia induced in normal males by spironolactone, Clin. Pharmacol. Ther. 24: 465–473.PubMedGoogle Scholar
  209. 209.
    Stepanas, A. V., Samaan, N. A., Schultz, P. N., and Holoye, P. Y., 1978, Endocrine studies in testicular tumor patients with and without gynecomastia: A report of 45 cases, Cancer 41: 369–376.PubMedCrossRefGoogle Scholar
  210. 210.
    Jeffreys, D. B., 1979, Painful gynaecomastia treated with tamoxifen, Br. Med. J. 1: 1119–1120.CrossRefGoogle Scholar
  211. 211.
    Spark, R. F., White, R. A., and Connolly, P. B., 1980, Impotence is not always psychogenic: Newer insights into hypothalamic—pituitary—gonadal dysfunction, J. Am. Med. Assoc. 243: 750–755.CrossRefGoogle Scholar
  212. 212.
    Bradley, W. E., 1980, Aspects of diabetic autonomic neuropathy, Ann. Intern. Med. 2 (Suppl., Part 2): 289–342.Google Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Daniel D. Federman
    • 1
  1. 1.Harvard Medical SchoolBostonUSA

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