The Thyroid

  • Kenneth A. Woeber
  • Lewis E. Braverman
Part of the Contemporary Endocrinology book series (COE, volume 2)


In the years that have elapsed since the publication of the first volume, some strides have been made in defining certain aspects of the localization, metabolic clearance, and disposition of thyrotropin-releasing hormone (TRH). This is due in large part to the increasing availability of improved methods for the radioimmunoassay (RIA) of TRH. A detailed review on all aspects of TRH physiology has recently been published.1


Thyroid Hormone Thyroid Carcinoma Medullary Thyroid Carcinoma Outer Ring Congenital Hypothyroidism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Jackson, I. M. D., 1982, Thyrotropin-releasing hormone, N. Engl. J. Med. 306: 145–155.PubMedCrossRefGoogle Scholar
  2. 2.
    Kubek, M., Wilber, J. F., and George, J. M., 1979, The distribution and concentration of thyrotropin-releasing hormone in discrete human hypothalamic nuclei, Endocrinology 105: 537–540.PubMedCrossRefGoogle Scholar
  3. 3.
    Aizawa, T., and Greer, M. A., 1981, Delineation of the hypothalamic area controlling thyrotropin secretion in the rat, Endocrinology 109: 1731–1738.PubMedCrossRefGoogle Scholar
  4. 4.
    Engler, D., Scanlon, M. F., and Jackson, I. M. D., 1981, Thyrotropinreleasing hormone in the systemic circulation of the neonatal rat is derived from the pancreas and other extraneural tissues, J. Clin. Invest. 67: 800–808.PubMedCrossRefGoogle Scholar
  5. 5.
    Shambaugh, G., III, Kubek, M., and Wilber, J. F., 1979, Thyrotropinreleasing hormone activity in the human placenta, J. Clin. Endocrinol. Metab. 48: 483–486.PubMedCrossRefGoogle Scholar
  6. 6.
    Youngblood, W. W., Humm, J., Lipton, M. A., and Kizer, J. S., 1980, Thyrotropin-releasing hormone-like bioactivity in placenta: Evidence for the existence of substances other than Pyroglu-His-Pro-NH2 (TRH) capable of stimulating pituitary thyrotropin release, Endocrinology 106: 541–546.PubMedCrossRefGoogle Scholar
  7. 7.
    Bhandaru, L., and Emerson, C. H., 1980, Evidence for the presence of the putative TRH metabolite, deamido-TRH, in human urine, J. Clin. Endocrinol. Metab. 51: 410–412.CrossRefGoogle Scholar
  8. 8.
    Emerson, C. H., Vogel, W., Currie, B. L., and Okal, T., 1980, Concentrations of thyrotropin-releasing hormone (TRH) and deamido-TRH, and TRH deamidase activity in brain, Endocrinology 107: 443–449.PubMedCrossRefGoogle Scholar
  9. 9.
    Yanagisawa, T., Prasad, C., and Peterkofsky, A., 1980, The subcellular and organ distribution and natural form of histidyl-proline diketopiperazine in rat brain determined by a specific radioimmunoassay, J. Biol. Chem. 255: 10290–10298.PubMedGoogle Scholar
  10. 10.
    Emerson, C. H., Alex, S., Braverman, L. E., and Safran, M. S., 1981, A study of the effect of the thyrotropin-releasing hormone metabolite, histidyl proline diketopiperazine, on prolactin in vivo, Endocrinology 109: 1375–1379.PubMedCrossRefGoogle Scholar
  11. 11.
    Morley, J. E., Garvin, T. J., Pekary, A. E., Utiger, R. D., Nair, M. G., Baugh, C. M., and Hershman, J. M., 1979, Plasma clearance and plasma half-disappearance time of exogenous thyrotropin-releasing hormone and pyroglutamyl-N’-methyl-histidyl prolineamide, J. Clin. Endocrinol. Metab. 48: 377–380.PubMedCrossRefGoogle Scholar
  12. 12.
    Emerson, C. H., Mishal, A., Mahabeer, H. L., and Currie, B. L., 1979, Lack of evidence for thyrotropin-releasing hormone deamidation in normal and hyperthyroid human sera, J. Clin. Endocrinol. Metab. 49: 138–140.PubMedCrossRefGoogle Scholar
  13. 13.
    Jackson, I. M. D., Papapetrou, P. D., and Reichlin, S., 1979, Metabolic clearance of thyrotropin-releasing hormone in the rat in hypothyroid and hyperthyroid states: Comparison with serum degradation in vitro, Endocrinology 104: 1292–1298.PubMedCrossRefGoogle Scholar
  14. 14.
    Naor, Z., Snyder, G., Fawcett, C. P., and McCann, S. M., 1980, Pituitary cyclic nucleotides and thyrotropin-releasing hormone action: The relationship of adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate to the release of thyrotropin and prolactin, Endocrinology 106: 1304–1310.PubMedGoogle Scholar
  15. 15.
    Snyder, G., Naor, Z., Fawcett, C. P., and McCann, S. M., 1981, Action of thyrotropin-releasing hormone on mammotrophs and thyrotrophs, Am. J. Physiol. 241: E298 - E304.PubMedGoogle Scholar
  16. 16.
    Roti, E., Gnudi, A., Robuschi, G., Emanuele, R., Benassi, L., and Braverman, L. E., 1982, Response of growth hormone (GH) to thyrotropinreleasing hormone (TRH) during fetal life, J. Clin. Endocrinol. Metab. 54: 1255–1257.PubMedCrossRefGoogle Scholar
  17. 17.
    Snyder, P. J., Muzyka, R., Johnson, J., and Utiger, R. D., 1980, Thyrotropin-releasing hormone provokes abnormal follicle-stimulating hormone (FSH) and luteinizing hormone responses in men who have pituitary adenomas and FSH hypersecretion, J. Clin. Endocrinol. Metab. 51: 744–748.PubMedCrossRefGoogle Scholar
  18. 18.
    Faden, A. I., Jacobs, T. P., and Holaday, J. W., 1981, Thyrotropin-releasing hormone improves neurologic recovery after spinal trauma in cats, N. Engl. J. Med. 305: 1063–1067.PubMedCrossRefGoogle Scholar
  19. 19.
    Holaday, J. W., D’Amato, R. J., and Faden, A. I., 1981, Thyrotropinreleasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock, Science 213: 216–218.PubMedCrossRefGoogle Scholar
  20. 20.
    Parker, D. C., Pekary, A. E., and Hershman, J. M., 1976, Effect of normal and reversed sleep—wake cycles upon nyctohemeral rhythmicity of plasma thyrotropin: Evidence suggestive of an inhibitory influence in sleep, J. Clin. Endocrinol. Metab. 43: 318–329.PubMedCrossRefGoogle Scholar
  21. 21.
    Minuto, F., Bagnasco, M., Giusti, M., Grimaldi, G., Biassoni, P., Ferrini, O., and Giordano, G., 1981, Twenty-four hour profile of integrated TSH concentration in puberty, J. Endocrinol. Invest. 4: 7–10.PubMedGoogle Scholar
  22. 22.
    Spencer, C. A., Greenstadt, M. A., Wheeler, W. S., Kletzky, O. A., and Nicoloff, J. T., 1980, The influence of long-term low dose thyrotropinreleasing hormone infusions on serum thyrotropin and prolactin concentrations in man, J. Clin. Endocrinol. Metab. 51: 771–775.PubMedCrossRefGoogle Scholar
  23. 23.
    Hinkle, P. M., Perrone, M. H., and Schonbrunn, A., 1981, Mechanism of thyroid hormone inhibition of thyrotropin-releasing hormone action, Endocrinology 108: 199–205.PubMedCrossRefGoogle Scholar
  24. 24.
    Silva, J. E., and Larsen, P. R., 1978, Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats, J. Clin. Invest. 61: 1247–1259.PubMedCrossRefGoogle Scholar
  25. 25.
    Larsen, P. R., Dick, T. E., Markovitz, B. P., Kaplan, M. M., and Gard, T. G., 1979, Inhibition of intrapituitary thyroxine to 3,5,3’-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats, J. Clin. Invest. 64: 117–128.PubMedCrossRefGoogle Scholar
  26. 26.
    Kleinmann, R. E., Vagenakis, A. G., and Braverman, L. E., 1980, The effect of iopanoic acid on the regulation of thyrotropin secretion in eu-thyroid subjects, J. Clin. Endocrinol. Metab. 51: 399–403.PubMedCrossRefGoogle Scholar
  27. 27.
    Larsen, P. R., 1982, Feedback regulation of thyrotropin secretion by thyroid hormones, N. Engl. J. Med. 306: 23–32.PubMedCrossRefGoogle Scholar
  28. 28.
    Scanlon, F., Chan, V., Heath, M., Pourmand, M., Rodriguez-Arnao, M. D., Weightman, R., Lewis, M., and Hall, R., 1981, Dopamine’ gic control of thyrotropin a-subunit, thyrotropin 3-subunit, and prolactin in euthyroidism and hypothyroidism: Dissociated responses to dopamine receptor blockade with metoclopramide in hypothyroid subjects, J. Clin. Endocrinol. Metab. 53: 360–365.PubMedCrossRefGoogle Scholar
  29. 29.
    Feek, C. M., Sawers, J. S. A., Brown, N. S., Seth, J., Irvine, W.J., and Toft, A. D., 1980, Influence of thyroid status on dopaminergic inhibition of thyrotropin and prolactin secretion: Evidence for an additional feedback mechanism in the control of thyroid hormone secretion, J. Clin. Endocrinol. Metab. 51: 585–589.PubMedCrossRefGoogle Scholar
  30. 30.
    Pamenter, R. W., and Hedge, G. A., 1980, Inhibition of thyrotropin secretion by physiological levels of corticosterone, Endocrinology 106: 162–166.PubMedCrossRefGoogle Scholar
  31. 31.
    Cobb, W. E., Reichlin, S., and Jackson, I. M. D., 1981, Growth hormone secretory status is a determinant of the thyrotropin response to thyrotropinreleasing hormone in euthyroid patients with hypothalamic—pituitary disease, J. Clin. Endocrinol. Metab. 52: 324–329.PubMedCrossRefGoogle Scholar
  32. 32.
    Tamagna, E. I., Hershman, J. M., and Jorgensen, E. C., 1979, Thyrotropin suppression by 3,5-dimethyl-3’-isopropyl-t.-thyroxine in man, J. Clin. Endocrinol. Metab. 48: 196–200.PubMedCrossRefGoogle Scholar
  33. 33.
    Bech, K., Feldt-Rasmussen, U., and Madsen, S. N., 1981, Influence of thyroglobulin on basal and stimulated human thyroid adenylate cyclase activity, J. Clin. Endocrinol. Metab. 53: 264–269.PubMedCrossRefGoogle Scholar
  34. 34.
    Zakarija, M., Witte, A., and McKenzie, J. M., 1980, Influence of cholera toxin on in vitro refractoriness to thyrotropin of thyroids from rats fed propylthiouracil, Endocrinology 107: 2045–2050.PubMedCrossRefGoogle Scholar
  35. 35.
    Holmes, S. D., Titus, G., Chou, M., and Field, J. B., 1980, Effects of thyrotropin and cholera toxin on the thyroidal adenylate cyclase—adenosine 3’,5’-monophosphate system, Endocrinology 107: 2076–2081.PubMedCrossRefGoogle Scholar
  36. 36.
    Zakarija, M., and McKenzie, J. M., 1980, Influences of cholera toxin on thyroid stimulation by thyrotropin and thyroid-stimulating antibody, Endocrinology 107: 2051–2054.PubMedCrossRefGoogle Scholar
  37. 37.
    Engström, G., and Ericson, L. E., 1981, Effect of graded doses of thyrotropin on exocytosis and early phase of endocytosis in the rat thyroid, Endocrinology 108: 399–405.PubMedCrossRefGoogle Scholar
  38. 38.
    Ericson, L. E., and Wollman, S. H., 1980, Increase in the rough endoplasmic reticulum in capillary endothelial cells and pericytes in hyperplastic rat thyroid glands, Endocrinology 107: 732–737.PubMedCrossRefGoogle Scholar
  39. 39.
    Laurberg, P., 1981, Iodothyronine secretion from perfused dog thyroid lobes after prolonged thyrotropin treatment in vivo, Endocrinology 109: 1560–1565.PubMedCrossRefGoogle Scholar
  40. 40.
    Laurberg, P., 1980, Iodothyronine release from the perfused canine thyroid following cessation of stimulation, J. Clin. Invest. 65: 488–495.PubMedCrossRefGoogle Scholar
  41. 41.
    Laurberg, P., 1980, Secretion of 3,3’-diiodothyronine by the perfused canine thyroid isolated in situ, Endocrinology 107: 989–993.PubMedCrossRefGoogle Scholar
  42. 42.
    Wollman, S. H., and Ekholm, R., 1981, Site of iodination in hyperplastic thyroid glands deduced from autoradiographs, Endocrinology 108: 2082–2085.PubMedCrossRefGoogle Scholar
  43. 43.
    Rosenberg, I. N., and Goswami, A., 1979, Purification and characterization of a flavoprotein from bovine thyroid with iodotyrosine deiodinase activity, J. Biol. Chem. 254: 12318–12325.PubMedGoogle Scholar
  44. 44.
    Hildebrandt, J. D., and Halmi, N. S., 1980, Intrathyroidally generated iodide: The role of propylthiouracil-sensitive processes in its production, Endocrinology 107: 830–838.PubMedCrossRefGoogle Scholar
  45. 45.
    Hildebrandt, J. D., and Halmi, N. S., 1981, Intrathyroidally generated iodide: The role of transport in its utilization, Endocrinology 108: 842–849.PubMedCrossRefGoogle Scholar
  46. 46.
    Chiraseveenuprapund, P., and Rosenberg, I. N., 1981, Effects of hydrogen peroxide-generating systems on the Wolff-Chaikoff effect, Endocrinology 109: 2095–2101.PubMedCrossRefGoogle Scholar
  47. 47.
    Uchimura, H., Chiu, S. C., Kuzaya, N., Ikeda, H., Ito, K., and Nagataki, S., 1980, Effect of iodine enrichment in vitro on the adenylate cyclaseadenosine 3’,5’-monophosphate system in thyroid glands from normal subjects and patients with Graves’ disease, J. Clin. Endocrinol. Metab. 50: 1066–1070.PubMedCrossRefGoogle Scholar
  48. 48.
    Sherwin, J. R., and Mills, I., 1980, Epinephrine inhibits thyrotropin-stimulated adenosine 3’,5’-monophosphate accumulation in cat thyroid tissue, Endocrinology 106: 28–34.PubMedCrossRefGoogle Scholar
  49. 49.
    Pisarev, M. A., Cardinali, D. P., Juvenal, G. J., Vacas, M. I., Barontini, M., and Boado, R. J., 1981, Role of the sympathetic nervous system in the control of the goitrogenic response in the rat, Endocrinology 109: 2202–2207.PubMedCrossRefGoogle Scholar
  50. 50.
    Maayan, M. L., Volpert, E. M., and From, A., 1981, Norepinephrine and thyrotropin effects on the thyroid in vitro: Simultaneous stimulation of iodide organification and antagonism of thyroxine release, Endocrinology 109: 930–934.PubMedCrossRefGoogle Scholar
  51. 51.
    Van Sande, J., Dumont, J. E., Melander, A., and Sundler, F., 1980, Presence and influence of cholinergic nerves in the human thyroid, J. Clin. Endocrinol. Metab. 51: 500–502.PubMedCrossRefGoogle Scholar
  52. 52.
    Ahren, B., Alumets, J., Ericsson, M., Fahrenkrug, J., Fahrenkrug, L., Hâkanson, R., Hedner, P., Loren, I., Melander, A., Rerup, C., and Sundler, F., 1980, VIP occurs in intrathyroidal nerves and stimulates thyroid hormone secretion, Nature (London) 287: 343–345.CrossRefGoogle Scholar
  53. 53.
    Van Herle, A. J., Vassart, G., and Dumont, J. E., 1979, Control of thyroglobulin synthesis and secretion, N. Engl. J. Med. 301: 307–314.PubMedCrossRefGoogle Scholar
  54. 54.
    Scherberg, N. H., Vassart, G., Lecocq, R., Dumont, J. E., and Refetoff, S., 1981, Modulation of thyroglobulin messenger RNA accumulation in the rat thyroid, Endocrinology 109: 1650–1656.PubMedCrossRefGoogle Scholar
  55. 55.
    Haeberli, A., Kneubuehl, F., and Studer, H., 1981, Changes in the polypeptide assembly of guinea pig thyroglobulin induced by thyrotropin-regulated thyroid activity, Endocrinology 109: 523–529.PubMedCrossRefGoogle Scholar
  56. 56.
    Ikekubo, K., Kishihara, M., Sanders, J., Sutton, J., and Schneider, A. B., 1981, Differences between circulating and tissue thyroglobulin in rats, Endocrinology 109: 427–432.PubMedCrossRefGoogle Scholar
  57. 57.
    Unger, J., Van Heuverswyn, B., Decoster, C., Cantraine, F., Mockel, J., and Van Herle, A., 1980, Thyroglobulin and thyroid hormone release after intravenous administration of bovine thyrotropin in man, J. Clin. Endocrinol. Metab. 51: 590–504.PubMedCrossRefGoogle Scholar
  58. 58.
    Bayer, M. F., and Kriss, J. P., 1979, Immunoradiometric assay for serum thyroglobulin: Semiquantitative measurement of thyroglobulin in antithyroglobulin-positive sera, J. Clin. Endocrinol. Metab. 49: 557–564.PubMedCrossRefGoogle Scholar
  59. 59.
    Mariotti, S., Martino, E., Cupini, C., Lari, R., Giani, C., Baschieri, L., and Pinchera, A., 1982, Low serum thyroglobulin as a clue to the diagnosis of thyrotoxicosis factitia, N. Engl. J. Med. 307: 410–412.PubMedCrossRefGoogle Scholar
  60. 60.
    Banerjee, R. K., and Datta, A. G., 1981, Gastric peroxidase—Localization, catalytic properties and possible role in extrathyroidal thyroid hormone formation, Acta Endocrinol. (Copenhagen) 96: 208–214.Google Scholar
  61. 61.
    Braverman, L. E., Ingbar, S. H., and Sterling, K., 1970, Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects, J. Clin. Invest. 49: 855–864.PubMedCrossRefGoogle Scholar
  62. 62.
    Chopra, I. J., 1980, A radioimmunoassay for measurement of 3’-monoiodothyronine, J. Clin. Endocrinol. Metab. 51: 117–123.PubMedCrossRefGoogle Scholar
  63. 63.
    Willets, P., Crossley, D. N., Ramsden, D. B., and Hoffenberg, R., 1979, The role of thyronine in thyroid hormone metabolism, J. Clin. Endocrinol. Metab. 49: 658–660.CrossRefGoogle Scholar
  64. 64.
    Faber, J., Busch-Srensen, M., Rogowski, P., Kirkegaard, C., SiersbaekNielsen, K., and Friss, T., 1981, Urinary excretion of free and conjugated 3’,5’-diiodothyronine and 3,3 ’ -diiodothyronine, J. Clin. Endocrinol. Metab. 53: 587–593.PubMedCrossRefGoogle Scholar
  65. 65.
    Faber, J., Faber, O. K., Lund, B., Kirkegaard, C., and Wahren, J., 1980, Hepatic extraction and renal production of 3,3’-diiodothyronine and 3’,5’diiodothyronine in man, J. Clin. Invest. 66: 941–945.PubMedCrossRefGoogle Scholar
  66. 66.
    McGuire, R. A., and Hays, M. T., 1981, A kinetic model of human thyroid hormones and their conversion products, J. Clin. Endocrinol. Metab. 53: 852–862.PubMedCrossRefGoogle Scholar
  67. 67.
    Warren, D. W., LoPresti, J. S., and Nicoloff, J. T., 1981, A new method for measurement of the conversion ration of thyroxine to triiodothyronine in eu thyroid man, J. Clin. Endocrinol. Metab. 53: 1218–1222.PubMedCrossRefGoogle Scholar
  68. 68.
    Pardridge, W. M., 1981, Transport of protein-bound hormones into tissues in vivo, Endocr. Rev. 2: 103–123.PubMedCrossRefGoogle Scholar
  69. 69.
    Pardridge, W. M., and Mietus, L. J., 1980, Influx of thyroid hormones into rat liver in vivo—differential availability of thyroxine and triiodothyronine bound by plasma proteins, J. Clin. Invest. 66: 367–374.PubMedCrossRefGoogle Scholar
  70. 70.
    Yoshida, K., and Davis, P. J., 1980, Estimation of intracellular free triiodothyronine in man, J. Clin. Endocrinol. Metab. 50: 667–669.PubMedCrossRefGoogle Scholar
  71. 71.
    Felicetta, J. V., Green, W. L., and Nelp, W. B., 1980, Inhibition of hepatic binding of thyroxine by cholecystographic agents, J. Clin. Invest. 65: 1032–1040.PubMedCrossRefGoogle Scholar
  72. 72.
    Acheson, K. J., and Burger, A. G., 1980, A study of the relationship between thermogenesis and thyroid hormones, J. Clin. Endocrinol. Metab. 51: 84–89.PubMedCrossRefGoogle Scholar
  73. 73.
    Emrich, D., and Weinheimer, B. (eds.), 1980, Thyroid 1979, J. Mol. Med. 4:3–258, 1980.Google Scholar
  74. 74.
    Melmed, S., Nademanee, K., Reed, A. W., Hendrickson, J. A., Singh, B. N., and Hershman, J. M., 1981, Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration, J. Clin. Endocrinol. Metab. 53: 997–1001.PubMedCrossRefGoogle Scholar
  75. 75.
    Chopra, I. J., Solomon, D. H., Teco, G. N. C., and Nguyen, A. H., 1980, Inhibition of hepatic outer ring monodeiodination of thyroxine and 3,3’,5’-triiodothyronine by sodium salicylate, Endocrinology 106: 1728–1734.PubMedCrossRefGoogle Scholar
  76. 76.
    Greeley, G. H., Jr., Jahnke, G., Nicholson, G. F., and Kizer, J. S., 1980, Decreased serum 3,5,3’-triiodothyronine and thyroxine levels accompanying acute and chronic ritalin treatment of developing rats, Endocrinology 106: 898–904.PubMedCrossRefGoogle Scholar
  77. 77.
    Cavalieri, R. R., and Pitt-Rivers, R., 1981, The effects of drugs on the distribution and metabolism of thyroid hormones, Pharm. Rev. 33: 55–80.PubMedGoogle Scholar
  78. 78.
    Chopra, I. J., Solomon, D. H., Teco, G. N. C., and Eisenberg, J. B., 1982, An inhibitor of the binding of thyroid hormones to serum proteins is present in extrathyroidal tissues, Science 215: 407–409.PubMedCrossRefGoogle Scholar
  79. 79.
    Kaptein, E. M., Spencer, C. A., Kamiel, M. B., and Nicoloff, J. T., 1980, Prolonged dopamine administration and thyroid hormone economy in normal and critically ill subjects, J. Clin. Endocrinol. Metab. 51: 387–393.PubMedCrossRefGoogle Scholar
  80. 80.
    Slag, M. F., Morley, J. E., Elson, M. K., Crowson, T. W., Nuttall, F. Q., and Shafer, R. B., 1981, Hypothyroxinemia in critically ill patients as a predictor of high mortality, J. Am. Med. Assoc. 245: 43–45.CrossRefGoogle Scholar
  81. 81.
    Kaptein, E. M., Grieb, D. A., Spencer, C. A., Wheeler, W. S., and Nicoloff, J. T., 1981, Thyroxine metabolism in the low thyroxine state of critical nonthyroidal illnesses, J. Clin. Endocrinol. Metab. 53: 764–771.PubMedCrossRefGoogle Scholar
  82. 82.
    Pardridge, W. M., Slag, M. F., Morley, J. E., Elson, M. K., Shafer, R. B., and Mietus, L. J., 1981, Hepatic bioavailability of serum thyroid hormones in nonthyroidal illness, J. Clin. Endocrinol. Metab. 53: 913–916.PubMedCrossRefGoogle Scholar
  83. 83.
    Geola, F. L., Chopra, I. J., and Geffner, D. L., 1980, Patterns of 3,3’,5’triiodothyronine monodeiodination in hypothyroidism and nonthyroid illnesses, J. Clin. Endocrinol. Metab. 50: 336–340.PubMedCrossRefGoogle Scholar
  84. 84.
    Braverman, L. E., Abreau, C. M., Brock, P., Kleinmann, R., Fournier, L., Odstrchel, G., and Schoemaker, H. J. P., 1980, Measurement of serum free thyroxine by RIA in various clinical states, J. Nucl. Med. 21: 233–239.Google Scholar
  85. 85.
    Chopra, I. J., Van Herle, A. J., Teco, G. N. C., and Nguyen, A. H., 1980, Serum free thyroxine in thyroidal and nonthyroidal illnesses: A comparison of measurements by radioimmunoassay, equilibrium dialysis, and free thyroxine index, J. Clin. Endocrinol. Metab. 51: 135–143.PubMedCrossRefGoogle Scholar
  86. 86.
    Bayer, M. F., and McDougall, I. R., 1980, Radioimmunoassay of free thyroxine in serum: Comparison with clinical findings and results of conventional thyroid-function tests, Clin. Chem. 26: 1186–1192.PubMedGoogle Scholar
  87. 87.
    Kaptein, E. M., Maclntyre, S. S., Weiner, J. M., Spencer, C. A., and Nicoloff, J. T., 1981, Free thyroxine estimates in nonthyroidal illness: Comparison of eight methods, J. Clin. Endocrinol. Metab. 52: 1073–1077.PubMedCrossRefGoogle Scholar
  88. 88.
    Melmed, S., Geola, F. L., Reed, A. W., Pekary, A. E., Park, J., and Hershman, J. M., 1982, A comparison of methods for assessing thyroid function in nonthyroidal illness, J. Clin. Endocrinol. Metab. 54: 300–306.PubMedCrossRefGoogle Scholar
  89. 89.
    Boss, A. M. B., and Kingstone, D., 1981, Further observations on serum free thyroxine concentrations during pregnancy, Br. Med. J. 283: 584.CrossRefGoogle Scholar
  90. 90.
    Slag, M. F., Morley, J. E., Elson, M. K., Labrosse, K. R., Crowson, T. W., Nuttall, F. Q., and Shafer, R. B., 1981, Free thyroxine levels in critically ill patients-A comparison of currently available assays, J. Am. Med. Assoc. 246: 2702–2706.CrossRefGoogle Scholar
  91. 91.
    Kaplan, M. M., Larsen, P. R., Crantz, F. R., Dzau, V. J., Rossing, T. H., and Haddow, J. E., 1982, Prevalence of abnormal thyroid function test results in patients with acute medical illnesses, Am. J. Med. 72: 9–16.PubMedCrossRefGoogle Scholar
  92. 92.
    Gavin, L. A., Rosenthal, M., and Cavalieri, R. R., 1979, The diagnostic dilemma of isolated hyperthyroxinemia in acute illness, J. Am. Med. Assoc. 242: 251–253.CrossRefGoogle Scholar
  93. 93.
    Cohen, K. L., and Swigar, M. E., 1979, Thyroid function screening in psychiatric patients, J. Am. Med. Assoc. 242: 254–257.CrossRefGoogle Scholar
  94. 94.
    Levy, R. P., Jensen, J. B., Laus, V. G., Agle, D. P., and Engel, I. M., 1981, Serum thyroid hormone abnormalities in psychiatric disease, Metabolism 30: 1060–1064.PubMedCrossRefGoogle Scholar
  95. 95.
    Pont, A., Spratt, D. I., McDougall, I. R., Miller, M. B., McLaughlin, W. T., and Bayer, M. F., 1981, Hyperthyroxinemia in acute psychiatric patients, Program of the American Thyroid Association, 57th Annual Meeting, p. T-4.Google Scholar
  96. 96.
    Gardner, D. F., Carithers, R. L., Jr., and Utiger, R. D., 1982, Thyroid function tests in patients with acute and resolved hepatitis B virus infection, Ann. Intern. Med. 96: 450–452.PubMedGoogle Scholar
  97. 97.
    Faber, J., Thomsen, H. F., Lumholtz, I. B., Kirkegaard, C., SiersbaekNielsen, K., and Friss, T., 1981, Kinetic studies of thyroxine, 3,5,3’-triiodothyronine, 3,3’,5’-triiodothyronine, 3’,5’-diiodothyronine, 3,3’-diiodothyronine, and 3’-monoiodothyronine in patients with liver cirrhosis, J. Clin. Endocrinol. Metab. 53: 978–984.PubMedCrossRefGoogle Scholar
  98. 98.
    Afrasiabi, M. A., Vaziri, N. D., Gwinup, G., Mays, D. M., Barton, C. H., Ness, R. L., and Valenta, L. J., 1979, Thyroid function studies in the nephrotic syndrome, Ann. Intern. Med. 90: 335–338.PubMedGoogle Scholar
  99. 99.
    Felicetta, J. V., Green, W. L., Haas, L. B., Kenny, M. A., Sherrard, D. J., and Brunzell, J. D., 1979, Thyroid function and lipids in patients with chronic renal disease treated by hemodialysis: With comments on the “free thyroxine index,” Metabolism 28: 756–763.PubMedCrossRefGoogle Scholar
  100. 100.
    Lim, V. S., Henriquez, C., Seo, H., Refetoff, S., and Martino, E., 1980, Thyroid function in a uremic rat model—Evidence suggesting tissue hypothyroidism, J. Clin. Invest. 66: 946–954.PubMedCrossRefGoogle Scholar
  101. 101.
    Thompson, P., Jr., Burman, K. D., Lukes, Y. G., McNeil, J. S., Jackson, B. D., Latham, K. R., and Wartofsky, L., 1980, Uremia decreases nuclear 3,5,3’-triiodothyronine receptors in rats, Endocrinology 107: 1081–1084.PubMedCrossRefGoogle Scholar
  102. 102.
    Fujii, S., Akai, T., Tanaka, S., Nakatani, K., Kinoshita, M., Seki, J., and Wada, M., 1981, Thyroid hormone abnormalities in patients with diabetes mellitus, J. Endocrinol. Invest. 4: 71–74.PubMedGoogle Scholar
  103. 103.
    Mayfield, R. K., Sagel, J., and Colwell, J. A., 1980, Thyrotoxicosis without elevated serum triiodothyronine levels during diabetic ketoacidosis, Arch. Intern. Med. 140: 408–410.PubMedCrossRefGoogle Scholar
  104. 104.
    Ahmad, N., and Cohen, M. P., 1981, Thyroid storm with normal serum triiodothyronine level during diabetic ketoacidosis, J. Am. Med. Assoc. 245: 2516–2517.CrossRefGoogle Scholar
  105. 105.
    Gonzalez, C., Montoya, E., Jolin, T., and Gonzalez, M., 1980, Effect of streptozotocin diabetes on the hypothalamic-pituitary-thyroid axis in the rat, Endocrinology 107: 2099–2103.PubMedCrossRefGoogle Scholar
  106. 106.
    Bagchi, N., Brown, T. R., Shivers, B., Lucas, S., and Mack, R. E., 1981, Decreased thyroidal response to thyrotropin in diabetic mice, Endocrinology 109: 1428–1432.PubMedCrossRefGoogle Scholar
  107. 107.
    Wiersinga, W. M., Frank, H. J. L., Chopra, I. J., and Solomon, D. H., 1982, Alterations in hepatic nuclear binding of triiodothyronine in experimental diabetes mellitus in rats, Acta Endocrinol. (Copenhagen) 99: 79–85.Google Scholar
  108. 108.
    Las, M. S., and Surks, M. L., 1981, Dissociation of serum triiodothyronine concentration and hepatic nuclear triiodothyronine-binding capacity in streptozotocin-induced diabetic rats, Endocrinology 109: 1259–1263.PubMedCrossRefGoogle Scholar
  109. 109.
    Das, D. K., and Ganguly, M., 1981, Diabetes, hypophysectomy, or thyroidectomy reduces nuclear L-triiodothyronine-binding capacity of rat lung, Endocrinology 109: 296–300.PubMedCrossRefGoogle Scholar
  110. 110.
    Maturlo, S. J., Rosenbaum, R. L., Pan, C., and Surks, M. I., 1980, Variable thyrotropin response to thyrotropin-releasing hormone after small decreases in plasma free thyroid hormone concentrations in patients with nonthyroidal diseases, J. Clin. Invest. 66: 451–456.PubMedCrossRefGoogle Scholar
  111. 111.
    Wood, D. G., and Samols, E., 1982, Impaired thyroid stimulating hormone secretion with decreased free T4 in nonthyroidal illness, Clin. Res. 30: 494A.Google Scholar
  112. 112.
    Kumara-Siri, M. H., Lee, K., and Surks, M. I., 1981, Regulation of thyrotropin secretion in rats bearing the Walker 256 carcinoma, Endocrinology 109: 1760–1768.PubMedCrossRefGoogle Scholar
  113. 113.
    Eisenstein, Z., Balsom, A., Garber, J. R., and Ingbar, S. H., 1980, A study of the properties of the enzyme in rat liver that deiodinates 3,3’,5’-triiodothyronine to 3,3’-diiodothyronine, Endocrinology 107: 530–537.PubMedCrossRefGoogle Scholar
  114. 114.
    Heinen, E., Basler, M., Herrmann, J., Hafner, D., and Krüskemper, H. L., 1980, Enzyme kinetic and substrate-binding studies of the thyroxine to 3,5,3’-triiodothyronine converting enzyme in the rat liver microsomal fraction, Endocrinology 107: 1198–1204.PubMedCrossRefGoogle Scholar
  115. 115.
    Chopra, I. J., 1981, Characteristics of outer ring (5’- or 3’-) monodeiodination of 3’,5’- and 3,3’-diiodothyronine: Evidence suggesting one outer ring monodeiodinase for various iodothyronines, Endocrinology 108: 464–471.PubMedCrossRefGoogle Scholar
  116. 116.
    Visser, T. J., Leonard, J. L., Kaplan, M. M., and Larsen, P. R., 1982, Molecular mechanisms of thyroid hormone 5’-deiodination in rat brain and pituitary, 64th Annual Meeting of the Endocrine Society, p. 132.Google Scholar
  117. 117.
    Maeda, M., and Ingbar, S. H., 1982, Evidence that the 5’-monodeiodinases for thyroxine (T4) and for 3,3’,5’-triiodothyronine (reverse T3, rT3) are separate enzymes, 64th Annual Meeting of the Endocrine Society, p. 133.Google Scholar
  118. 118.
    dem Brinke, D. A., Köhrle, J., Ködding, R., and Hesch, R.-D., 1980, Sub-cellular localization of thyroxine-5-deiodinase in rat liver, J. Endocrinol. Invest. 3: 73–76.Google Scholar
  119. 119.
    Cavalieri, R. R., Gavin, L. A., and Bui, F., 1977, Conversion of thyroxine to 3,3’,5’-triiodothyronine (reverse-T3) by a soluble enzyme system of rat liver, Biochem. Biophys. Res. Commun. 79: 897–902.PubMedCrossRefGoogle Scholar
  120. 120.
    Fekkes, D., Overmeeren-Kaptein, E. V., Docter, R., Hennemann, G., and Visser, T. J., 1979, Location of rat liver iodothyronine deiodinating enzymes in the endoplasmic reticulum, Biochim. Biophys. Acta 587: 12–19.PubMedCrossRefGoogle Scholar
  121. 121.
    Maciel, R. M. B., Ozawa, Y., and Chopra, I.J., 1979, Subcellular localization of thyroxine and reverse triiodothyronine outer ring monodeiodinating activities, Endocrinol. 104: 365–370.CrossRefGoogle Scholar
  122. 122.
    Takaishi, M., Shimizu, T., and Shishiba, Y., 1979, Solubilization of thyroxine-5’-deiodinase activity from rat liver microsome fraction, Acta Endocrinol. (Copenhagen) 92: 694–701.Google Scholar
  123. 123.
    Fekkes, D., Overmeeren, E. V., Hennemann, G., and Visser, T. J., 1980, Solubilization and partial characterization of rat liver iodothyronine deiodinases, Biochim. Biophys. Acta 613: 41–51.PubMedCrossRefGoogle Scholar
  124. 124.
    Leonard, J. L., and Rosenberg, I. N., 1980, lodothyronine 5’-deiodinase from rat kidney: Substrate specificity and the 5’-deiodination of reverse triiodothyronine, Endocrinology 107: 1376–1383.PubMedCrossRefGoogle Scholar
  125. 125.
    Kaplan, M. M., 1980, Thyroxine 5’-monodeiodination in rat anterior pituitary homogenates, Endocrinology 106: 567–576.PubMedCrossRefGoogle Scholar
  126. 126.
    Crantz, F. R., and Larsen, P. R., 1980, Rapid thyroxine to 3,5,3’-triiodothyronine conversion and nuclear 3,5,3’-triiodothyronine binding in rat cerebral cortex and cerebellum, J. Clin. Invest. 65: 935–938.PubMedCrossRefGoogle Scholar
  127. 127.
    Kaplan, M. M., McCann, U. D., Yaskoski, K. A., Larsen, P. R., and Leonard, J. L., 1981, Anatomical distribution of phenolic and tyrosyl ring iodothyronine deiodinases in the nervous system of normal and hypothyroid rats, Endocrinology 109: 397–402.PubMedCrossRefGoogle Scholar
  128. 128.
    Tanaka, K., Inada, M., Ishii, H., Naito, K., Nishikawa, M., Mashio, Y., and Imura, H., 1981, Inner ring monodeiodination of thyroxine and 3,5,3’-Ltriiodothyronine in rat brain, Endocrinology 109: 1619–1624.PubMedCrossRefGoogle Scholar
  129. 129.
    Leonard, J. L., Kaplan, M. M., Visser, T. J., Silva, J. E., and Larsen, P. R., 1981, Cerebral cortex responds rapidly to thyroid hormones, Science 214: 571–573.PubMedCrossRefGoogle Scholar
  130. 130.
    Nishikawa, M., Inada, M., Naito, K., Ishii, H., Tanaka, K., Mashio, Y., Nakao, K., Nakai, Y., Udaka, F., and Imura, H., 1981, 3,3’,5’-triiodothyronine (reverse T3) in human cerebrospinal fluid, J. Clin. Endocrinol. Metab. 53: 1030–1035.PubMedCrossRefGoogle Scholar
  131. 131.
    Melmed, S., Nelson, M., Kaplowitz, N., Yamada, T., and Hershman, J. M., 1981, Glutathione-dependent thyroxine 5’-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells, Endocrinology 108: 970–976.PubMedCrossRefGoogle Scholar
  132. 132.
    Roti, E., Fang, S. L., Green, K., Emerson, C. H., and Braverman, L. E., 1981, Human placenta is an active site of thyroxine and 3,3’,5-triiodothyronine tyrosyl ring deiodination, J. Clin. Endocrinol. Metab. 53: 498–501.PubMedCrossRefGoogle Scholar
  133. 133.
    Roti, E., Fang, S. L., Braverman, L. E., and Emerson, C. H., 1982, Rat placenta is an active site of inner ring deiodination of thyroxine and 3,3’,5triiodothyronine, Endocrinology 110: 34–37.PubMedCrossRefGoogle Scholar
  134. 134.
    Roti, E., Fang, S. L., Green, K., Braverman, L. E., and Emerson, C. H., 1983, Inner ring deiodination of thyroxine and 3,3’,5-triiodothyronine by human fetal membranes, Am. J. Obstet. Gynecol. 147: 788–792.PubMedGoogle Scholar
  135. 135.
    El-Zaheri, M., Vagenakis, A. G., Hinerfeld, L., Emerson, C. H., and Braverman, L. E., 1981, Maternal thyroid function is the major determinant of amniotic fluid reverse T3 in the rat, J. Clin. Invest. 67: 1126–1133.PubMedCrossRefGoogle Scholar
  136. 136.
    Erickson, V. J., Cavalieri, R. R., and Rosenberg, L. L., 1981, Phenolic and nonphenolic ring iodothyronine deiodinases from rat thyroid gland, Endocrinology 108: 1257–1264.PubMedCrossRefGoogle Scholar
  137. 137.
    Ishii H., Inada, M., Tanaka, K., Mashio, Y., Natto, K., Nishikawa, M., and Imura, H., 1981, Triiodothyronine generation from thyroxine in human thyroid: Enhanced conversion in Graves’ thyroid tissue, J. Clin. Endocrinol. Metab. 52: 1211–1217.PubMedCrossRefGoogle Scholar
  138. 138.
    Borges, M., Eisenstein, Z., Burger, A. G., and Ingbar, S. H., 1981, Immunsequestration: A new technique for studying peripheral iodothyronine metabolism in vitro, Endocrinology 108: 1665–1671.PubMedCrossRefGoogle Scholar
  139. 139.
    Pittman, C. S., Shimizu, T., Burger, A., and Chambers, J. B., Jr., 1980, The nondeiodinative pathways of thyroxine metabolism: 3,5,3’,5’-tetraiodothyroacetic acid turnover in normal and fasting human subjects, J. Clin. Endocrinol. Metab. 50: 712–716.PubMedCrossRefGoogle Scholar
  140. 140.
    Gavin, L. A., Bui, F., McMahon, F., and Cavalieri, R. R., 1980, Sequential deiodination of thyroxine to 3,3’-diiodothyronine via 3,5,3’-triiodothyronine and 3,3’,5’-triiodothyronine in rat liver homogenate, J. Biol. Chem. 254: 49–53.Google Scholar
  141. 141.
    Gavin, L. A., McMahon, F. A., and Moeller, M., 1981, Dietary modification of thyroxine deiodination in liver is not mediated by hepatic sulfhydryls, J. Clin. Invest. 65: 943–946.CrossRefGoogle Scholar
  142. 142.
    Harris, A. R., Fang, S. L., Hinerfeld, L., Braverman, L. E., and Vagenakis, A. G., 1979, The role of sulfhydryl groups on the impaired hepatic 3’,3,5triiodothyronine generation from thyroxine in the hypothyroid, starved, fetal, and neonatal rodent, J. Clin. Invest. 63: 516–524.PubMedCrossRefGoogle Scholar
  143. 143.
    Balsam, A., Ingbar, S. H., and Sexton, F., 1979, Observations on the factors that control the generation of triiodothyronine from thyroxine in rat liver and the nature of the defect induced by fasting, J. Clin. Invest. 63: 1145–1156.PubMedCrossRefGoogle Scholar
  144. 144.
    Kaplan, M. M., 1979, Subcellular alterations causing reduced hepatic thyroxine-5’-monodeiodinase activity in fasted rats, Endocrinology 104: 58–64.PubMedCrossRefGoogle Scholar
  145. 145.
    Chopra, I. J., 1980, Alterations in monodeiodination of iodothyronines in the fasting rat: Effects of reduced nonprotein sulfhydryl groups and hypothyroidism, Metabolism 29: 161–167.PubMedCrossRefGoogle Scholar
  146. 146.
    Gavin, L. A., McMahon, F. A., and Moeller, M., 1981, Carbohydrate in contrast to protein feeding increases the hepatic content of active thyroxine-5’-deiodinase in the rat, Endocrinology 109: 530–536.PubMedCrossRefGoogle Scholar
  147. 147.
    Sato, K., and Robbins, J., 1981, Thyroid hormone metabolism in primary cultured rat hepatocytes, J. Clin. Invest. 68: 475–483.PubMedCrossRefGoogle Scholar
  148. 148.
    Senga, O., Pittman, C. S., Lindsay, R. H., Chambers, J. B., Jr., and Hill, J. B., Jr., 1982, Comparison of the peripheral thyroid hormone metabolism in normal rats and in rats receiving prolonged glucagon infusion, Endocrinology 110: 2011–2017.PubMedCrossRefGoogle Scholar
  149. 149.
    Sorimachi, K., and Robbins, J., 1978, Thyroxine inactivation by starvation in cultured hepatocarcinoma cells: Formation of reverse triiodothyronine, Norm. Metab. Res. 10: 459–575.CrossRefGoogle Scholar
  150. 150.
    Sato, K., and Robbins, J., 1981, Glutathione deficiency induced by cystine and/or methionine deprivation does not affect thyroid hormone deiodination in cultured rat hepatocytes and monkey hepatocarcinoma cells, Endocrinology 109: 844–852.PubMedCrossRefGoogle Scholar
  151. 151.
    Takai, N. A., Rapoport, B., and Yamamoto, M., 1980, Biliary excretion of iodothyronines in rats as determined by high pressure liquid chromatography: Effect of starvation, Endocrinology 107: 176–182.PubMedCrossRefGoogle Scholar
  152. 152.
    Balsam, A., Sexton, F., and Ingbar, S. H., 1981, The influence of fasting and the thyroid state on the activity of thyroxine 5’-monodeiodinase in rat liver: a kinetic analysis of microsomal formation of triiodothyronine from thyroxine, Endocrinology 108: 472–477.PubMedCrossRefGoogle Scholar
  153. 153.
    Burger, A. G., Weissel, M., and Berger, M., 1980, Starvation induces a partial failure of triiodothyronine to inhibit the thyrotropin response to thyrotropin-releasing hormone, J. Clin. Endocrinol. Metab. 51: 1064–1067.PubMedCrossRefGoogle Scholar
  154. 154.
    Gardner, D. F., Kaplan, M. M., Stanley, C. A., and Utiger, R. D., 1979, Effect of tri-iodothyronine replacement on the metabolic and pituitary responses to starvation, N. Engl. J. Med. 300: 579–584.PubMedCrossRefGoogle Scholar
  155. 155.
    Schwartz, H. L., Lancer, S. R., and Oppenheimer, J. H., 1980, Thyroid hormones influence starvation-induced hepatic protein loss in the rat: Possible role of thyroid hormones in the generation of labile protein, Endocrinology 107: 1684–1692.PubMedCrossRefGoogle Scholar
  156. 156.
    Oppenheimer, J. H., and Schwartz, H. L., 1980, Factors determining the level of activity of 3,5,3’-triiodothyronine-responsive hepatic enzymes in the starved rat, Endocrinology 107: 1460–1468.PubMedCrossRefGoogle Scholar
  157. 157.
    Mariash, C. N., Kaiser, F. E., Schwartz, H. L., Towle, H. C., and Oppenheimer, J. H., 1980, Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat, J. Clin. Invest. 67: 1126–1134.CrossRefGoogle Scholar
  158. 158.
    Forciea, M. A., Schwartz, H. L., Towle, H. C., Mariash, C. N., Kaiser, F. E., and Oppenheimer, J. H., 1981, Thyroid hormone-carbohydrate interaction in the rat, J. Clin. Invest. 67: 1739–1747.PubMedCrossRefGoogle Scholar
  159. 159.
    Mariash, C. N., McSwigan, C. R., Towle, H. C., Schwartz, H. L., and Oppenheimer, J. H., 1981, Glucose and triiodothyronine both induce malic enzyme in the rat hepatocyte culture, J. Clin. Invest. 68: 1485–1490.PubMedCrossRefGoogle Scholar
  160. 160.
    Simat, B. M., Towle, H. C., Schwartz, H. L., and Oppenheimer, J. H., 1980, Difference between thyroidectomized and hypophysectomized animals in their hepatic ribonucleic acid response to thyroid hormone, Endocrinology 107: 1338–1344.PubMedCrossRefGoogle Scholar
  161. 161.
    Walker, P., Weichsel, M. E., Jr., Hoath, S. B., Poland, R. E., and Fisher, D. A., 1981, Effect of thyroxine, testosterone, and corticosterone on nerve growth factor (NGF) and epidermal growth factor (EGF) concentrations in adult female mouse submaxillary gland: Dissociation of NGF and EGF responses, Endocrinology 109: 582–587.PubMedCrossRefGoogle Scholar
  162. 162.
    Gambert, S. R., Ingbar, S. H., and Hagen, T. C., 1981, Interaction of age and thyroid hormone status on Nat-K+ ATPase in rat renal cortex and liver, Endocrinology 108: 27–30.PubMedCrossRefGoogle Scholar
  163. 163.
    Dratman, M. B., Futaesaku, Y., Crutchfield, F. L., Berman, N., Payne, B., Sar, M., and Stumpf, W. E., 1982, Iodine-125-labeled triiodothyronine in rat brain: Evidence for localization in discrete neural systems, Science 215: 309–312.PubMedCrossRefGoogle Scholar
  164. 164.
    Kriz, B. M., Fong, B. B., and Goldfine, I. D., 1981, Quantitative electron microscope autoradiographs of 125I-L-triiodothyronine: Evidence for multiple sites of hormone localization, Clin. Res. 29: 506A.Google Scholar
  165. 165.
    Sterling, K., 1979, Thyroid hormone action at the cell level, N. Engl. J. Med. 300: 117–124, 173–177.CrossRefGoogle Scholar
  166. 166.
    Segal, J., and Ingbar, S. H., 1980, Direct and synergistic interactions of 3,5,3’-triiodothyronine and the adrenergic system in stimulating sugar transport by rat thymocytes, J. Clin. Invest. 65: 958–966.PubMedCrossRefGoogle Scholar
  167. 167.
    Maxfield, F. R., Willingham, M. C., Pastan, I., Dragsten, P., and Cheng, S.-Y., 1981, Binding and mobility of the cell surface receptors for 3,3’,5triiodo-L-thyronine, Science 211: 63–64.PubMedCrossRefGoogle Scholar
  168. 168.
    Young, R. A., Braverman, L. E., and Rajatanavin, R., 1982, Low protein-high carbohydrate diet induces alterations in the serum thyronine binding proteins in the rat, Endocrinology 110: 1607–1612.PubMedCrossRefGoogle Scholar
  169. 169.
    Smallridge, R. C., Glass, A. R., Wartofsky, L., Ward, K. G., and Burman, K. D., 1980, Investigations into the etiology of elevated serum triiodothyronine (T3) levels in protein malnourished rats, 62nd Annual Meeting of the Endocrine Society, p. 223.Google Scholar
  170. 170.
    Okamura, K., Taurog, A., and Krulich, L., 1981, Elevation of serum 3,5,3’triiodothyronine and thyroxine levels in rats fed Remington diets: Opposing effects of nutritional deficiency and iodine deficiency, Endocrinology 108: 1247–1256.PubMedCrossRefGoogle Scholar
  171. 171.
    Okamura, K., Taurog, A., and DiStefano, J. J., III, 1981, Elevated serum levels of T3 without metabolic effect in nutritionally deficient rats, attributable to reduced cellular uptake of T3, Endocrinology 109: 673–675.PubMedCrossRefGoogle Scholar
  172. 172.
    Hennemann, G., Docter, R., Krenning, E. P., Bos, G., Otten, M., and Visser, T. J., 1979, Raised total thyroxine and free thyroxine index but normal free thyroxine: A serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein, Lancet 1: 639–642.PubMedCrossRefGoogle Scholar
  173. 173.
    Lee, W. N. P., Golden, M. P., van Herle, A. J., Lippe, B. M., and Kaplan, S. A., 1979, Inherited abnormal thyroid hormone-binding protein causing selective increase of total serum thyroxine, J. Clin. Endocrinol. Metab. 49: 292–299.PubMedCrossRefGoogle Scholar
  174. 174.
    Stockigt, J. R., Topliss, D. J., Barlow, J. W., White, E. L., Hurley, D. M., and Taft, P., 1981, Familial euthyroid thyroxine excess: An appropriate response to abnormal thyroxine binding associated with albumin, J. Clin. Endocrinol. Metab. 53: 353–359.PubMedCrossRefGoogle Scholar
  175. 175.
    Ruiz, M., Rajatanavin, R., Young, R. A., Taylor, C., Brown, R., Braverman, L. E., and Ingbar, S. H., 1982, Familial dysalbuminemic hyperthyroxinemia, N. Engl. J. Med. 306: 635–639.PubMedCrossRefGoogle Scholar
  176. 176.
    Moses, A. C., Lawlor, J., Haddow, J., and Jackson, I. M. D., 1982, Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin, N. Engl. J. Med. 306: 966–969.PubMedCrossRefGoogle Scholar
  177. 177.
    Morley, J. E., Shafer, R. B., Elson, M. K., Slag, M. F., Raleigh, M. J., Brammer, G. L., Yuwiler, A., and Hershman, J. M., 1980, Amphetamine-induced hyperthyroxinemia, Ann. Intern. Med. 93: 707–709.PubMedGoogle Scholar
  178. 178.
    Geola, F. L., Hershman, J. M., Reed, A. W., and Premachandra, B. N., 1981, Circulating thyroid hormone autoantibodies in a hypothyroid patient: Effect on thyroxine metabolic clearance rate, J. Clin. Endocrinol. Me-tab. 53: 580–586.CrossRefGoogle Scholar
  179. 179.
    Inada, M., Nishikawa, M., Naito, K., Oishi, M., Kurata, S., and Imura, H., 1980, Triiodothyronine-binding immunoglobulin in a patient with Graves’ disease and its effect on metabolism and radioimmunoassay of triiodothyronine, Am. J. Med. 68: 787–792.CrossRefGoogle Scholar
  180. 180.
    Gärtner, R., Henze, R., Horn, K., Pickardt, C. R., and Scriba, P. C., 1981, Thyroxine-binding globulin: Investigation of microheterogeneity, J. Clin. Endocrinol. Metab. 52: 657–664.PubMedCrossRefGoogle Scholar
  181. 181.
    Garnick, M. B., and Larsen, P. R., 1979, Acute deficiency of thyroxine-binding globulin during L-asparaginase therapy, N. Engl. J. Med. 301: 252–253.PubMedCrossRefGoogle Scholar
  182. 182.
    Yabu, Y., Amino, N., Nakatani, K., Ichihara, K., Azukizawa, M., and Miyai, K., 1980, Graves’ disease associated with elevated serum thyroxine-binding globulin concentrations, J. Clin. Endocrinol. Metab. 51: 325–329.PubMedCrossRefGoogle Scholar
  183. 183.
    Smals, A. G., Ross, A. H., and Kloppenborg, P. W. C., 1981, Dichotomy between serum free triiodothyronine and free thyroxine concentrations in familial thyroxine-binding globulin deficiency, J. Clin. Endocrinol. Metab. 53: 917–922.PubMedCrossRefGoogle Scholar
  184. 184.
    Fisher, D. A., and Klein, A. H., 1981, Thyroid development and disorders of thyroid function in the newborn, N. Engl. J. Med. 304: 702–712.PubMedCrossRefGoogle Scholar
  185. 185.
    Porterfield, S. P., and Hendrich, C. E., 1981, Alterations of serum thyroxine, triiodothyronine, and thyrotropin in the progeny of hypothyroid rats, Endocrinology 108: 1060–1063.PubMedCrossRefGoogle Scholar
  186. 186.
    Coulombe, P., Ruel, J., and Dussault, J. H., 1980, Effects of neonatal hypo-and hyperthyroidism on pituitary growth hormone content in the rat, Endocrinology 107: 2027–2033.PubMedCrossRefGoogle Scholar
  187. 187.
    Avivi, A., Shemesh, M., and Lindner, H. R., 1981, The ontogeny of the thyrotropin-thyroid axis in early bovine embryos, Endocrinology 109: 1611–1618.PubMedCrossRefGoogle Scholar
  188. 188.
    Oliver, C., Giraud, P., Lissitzky, J. C., Conte-Devolx, B., and Gillioz, P., 1981, Influence of thyrotropin-releasing hormone on the secretion of thyrotropin in neonatal rats, Endocrinology 108: 179–182.PubMedCrossRefGoogle Scholar
  189. 189.
    Theodoropoulos, T., Braverman, L. E., and Vagenakis, A. G., 1979, Thyrotropin-releasing hormone is not required for thyrotropin secretion in the perinatal rat, J. Clin. Invest. 63: 588–594.PubMedCrossRefGoogle Scholar
  190. 190.
    Tonooka, N., and Greer, M. A., 1978, Evidence that control of fetal thyrotropin secretion is independent of both the fetal and maternal hypothalamus, Endocrinology 102: 852–858.PubMedCrossRefGoogle Scholar
  191. 191.
    Frankel, S., and Lange, G., 1980, Maturation of hypothalamic-pituitary-thyroid response in the rat to acute cold, Am. J. Physiol. Endocrinol. Metab. 2: E223 - E226.Google Scholar
  192. 192.
    Walker, P., Coulombe, P., and Dussault, J. H., 1980, Effects of triiodothyronine on thyrotropin-releasing hormone-induced thyrotropin release in the neonatal rat, Endocrinology 107: 1731–1737.PubMedCrossRefGoogle Scholar
  193. 193.
    Klein, A. H., and Fisher, D. A., 1980, Thyrotropin-releasing hormone-stimulated pituitary and thyroid gland responsiveness and 3,5,3’-triiodothyronine suppression in fetal and neonatal lambs, Endocrinology 106: 697–701.PubMedCrossRefGoogle Scholar
  194. 194.
    Roti, E., Gnudi, A., Braverman, L. E., Robuschi, G., Emanuele, R., Bandini, P., Benassi, L., Pagliani, A., and Emerson, C. H., 1981, Human cord blood concentrations of thyrotropin, thyroglobulin, and iodothyronines after maternal administrations of thyrotropin-releasing hormone, J. Clin. Endocrinol. Metab. 53: 813–817.PubMedCrossRefGoogle Scholar
  195. 195.
    Pezzino, V., Filetti, S., Belfiore, A., Proto, S., Donzelli, G., and Vigneri, R., 1981, Serum thyroglobulin levels in the newborn, J. Clin. Endocrinol. Metab. 52: 364–366.PubMedCrossRefGoogle Scholar
  196. 196.
    Ket, J. L., de Vijlder, J. J. M., Bikker, H., Gons, M. H., and Tegelaers, W. H. H., 1981, Serum thyroglobulin levels: The physiological decrease in infancy and the absence in athyroidism, J. Clin. Endocrinol. Metab. 53: 1301–1303.PubMedCrossRefGoogle Scholar
  197. 197.
    Tenore, A., Parks, J. S., Gasparo, M., and Koldovsky, O., 1980, Thyroidal response to peroral TSH in suckling and weaned rats, Am. J. Physiol. Endocrinol. Metab. 1: E428 — E430.Google Scholar
  198. 198.
    Borges, M., LaBourene, J., and Ingbar, S. H., 1980, Changes in hepatic iodothyronine metabolism during ontogeny of the chick embryo, Endocrinology 107: 1751–1761.PubMedCrossRefGoogle Scholar
  199. 199.
    Galton, V. A., and Munck, K., 1981, Metabolism of thyroxine in Rana catesbeiana tadpoles during metamorphic climax, Endocrinology 109: 1127–1131.PubMedCrossRefGoogle Scholar
  200. 200.
    Galton, V. A., 1980, Binding of thyroid hormones in vivo by hepatic nuclei of Rana catesbeiana tadpoles at different stages of metamorphosis, Endocrinology 107: 1910–1915.PubMedCrossRefGoogle Scholar
  201. 201.
    Galton, V. A., and Cohen, J. S., 1980, Action of thyroid hormones in premetamorphic tadpoles: An important role of thyroxine?, Endocrinology 107: 1820–1826.PubMedCrossRefGoogle Scholar
  202. 202.
    Gonzales, L. W., and Ballard, P. L., 1981, Identification and characterization of nuclear 3,5,3’-triiodothyronine-binding sites in fetal human lung, J. Clin. Endocrinol. Metab. 53: 21–28.PubMedCrossRefGoogle Scholar
  203. 203.
    Hitchcock, K. R., Harney, J., and Reichlin, S., 1980, Hormones and the lung. III. Thyroid hormone uptake kinetics of perinatal rat lung, Endocrinology 107: 294–299.PubMedCrossRefGoogle Scholar
  204. 204.
    Ballard, P. L., Benson, B. J., Brehier, A., Carter, J. P., Kriz, B. M., and Jorgensen, E. C., 1980, Transplacental stimulation of lung development in the fetal rabbit by 3,5-dimethyl-3’-isopropyl-L-thyroxine, J. Clin. Invest. 65: 1407–1417.PubMedCrossRefGoogle Scholar
  205. 205.
    Matsuura, N., Yamada, Y., Nohara, Y., Konishi, J., Kasagi, K., Endo, K., Kojima, H., and Wataya, K., 1980, Familial neonatal transient hypothyroidism due to maternal TSH-binding inhibitor immunoglobulins, N. Engl. J. Med. 303: 738–741.PubMedCrossRefGoogle Scholar
  206. 206.
    Czernichow, P., Vandalem, J. L., and Hennen, G., 1981, Transient neonatal hyperthyrotropinemia: A factitious syndrome due to the presence of heterophilic antibodies in the plasma of infants and their mothers, J. Clin. Endocrinol. Metab. 53: 387–393.PubMedCrossRefGoogle Scholar
  207. 207.
    Gendrel, D., Feinstein, M.-C., Grenier, J., Roger, M., Ingrand, J., Chaussain, J.-L., Canlorbe, P., and Job, J.-B., 1981, Falsely elevated serum thyrotropin (TSH) in newborn infants: Transfer from mothers to infants of a factor interfering in the TSH radioimmunoassay, J. Clin. Endocrinol. Metab. 52: 62–65.PubMedCrossRefGoogle Scholar
  208. 208.
    Sugenoya, A., Kidd, A., Row, V. V., and Volpe, R., 1979, Correlation between thyrotropin-displacing activity and human thyroid-stimulating activity by immunoglobulins from patients with Graves’ disease and other thyroid disorders, J. Clin. Endocrinol. Metab. 48: 398–402.PubMedCrossRefGoogle Scholar
  209. 209.
    Kuzuya, N., Chiu, S. C., Ikeda, H., Uchimura, H., Ito, K., and Nagataki, S., 1979, Correlation between thyroid stimulators and 3,5,3’-triiodothyronine suppressibility in patients during treatment for hyperthyroidism with thionamide drugs: Comparison of assays by thyroid-stimulating and thyrotropin-displacing activities, J. Clin. Endocrinol. Metab. 48: 706–711.PubMedCrossRefGoogle Scholar
  210. 210.
    Endo, K., Amir, S. M., and Ingbar, S. H., 1981, Development and evaluation of a method for the partial purification of immunoglobulins specific for Graves’ disease, J. Clin. Endocrinol. Metab. 52: 1113–1123.PubMedCrossRefGoogle Scholar
  211. 211.
    Kishihara, M., Nakao, Y., Baba, Y., Kobayashi, N., Matsukura, S., Kuma, K., and Fujita, T., 1981, Interaction between thyrotropin (TSH) binding inhibitor immunoglobulins (TBII) and soluble TSH receptors in fat cells, J. Clin. Endocrinol. Metab. 52: 665–670.PubMedCrossRefGoogle Scholar
  212. 212.
    Davies, T. F., 1981, Autoantibodies to the human thyrotropin receptor are not species specific, J. Clin. Endocrinol. Metab. 52: 426–430.PubMedCrossRefGoogle Scholar
  213. 213.
    Ealey, P. A., Marshall, N. J., and Ekins, R. P., 1981, Time-related thyroid stimulation by thyrotropin and thyroid-stimulating antibodies, as measured by the cytochemical section bioassay, J. Clin. Endocrinol. Metab. 52: 483–487.PubMedCrossRefGoogle Scholar
  214. 214.
    Loveridge, N., Zakarija, M., Bitensky, L., and McKenzie, J. M., 1979, The cytochemical bioassay for thyroid-stimulating antibody of Graves’ disease: Further experience, J. Clin. Endocrinol. Metab. 49: 610–615.PubMedCrossRefGoogle Scholar
  215. 215.
    Hinds, W. E., Takai, N., Rapoport, B., Filetti, S., and Clark, O. H., 1981, Thyroid-stimulating immunoglobulin bioassay using cultured human thyroid cells, J. Clin. Endocrinol. Metab. 52: 1204–1210.PubMedCrossRefGoogle Scholar
  216. 216.
    Stöcke, G., Wahl, R., and Seif, F. J., 1981, Micromethod of human thyrocyte cultures for detection of thyroid-stimulating antibodies and thyrotropin, Acta Endocrinol. (Copenhagen) 97: 369–375.Google Scholar
  217. 217.
    Bidey, S. P., Marshall, N. J., and Ekins, R. P., 1981, Adenylate cyclase activity and the accumulation and release of adenosine 3’,5’-monophosphate in normal human thyroid tissue slice preparations: Responses to thyrotropin and thyroid-stimulating antibodies, J. Clin. Endocrinol. Metab. 53: 246–253.PubMedCrossRefGoogle Scholar
  218. 218.
    Atkinson, S., and Kendall-Taylor, P., 1981, The stimulation of thyroid hormone secretion in vitro by thyroid-stimulating antibodies, J. Clin. Endocrinol. Metab. 53: 1263–1266.PubMedCrossRefGoogle Scholar
  219. 219.
    Ozawa, Y., Maciel, R. M. B., Chopra, I. J., Solomon, D. H., and Beall, G. N., 1979, Relationships among immunoglobulin markers in Graves’ disease, J. Clin. Endocrinol. Metab. 48: 381–387.PubMedCrossRefGoogle Scholar
  220. 220.
    Kasagi, K., Konishi, J., Endo, K., Mori, T., Nagahara, K., Makimoto, K., Kuma, K., and Torizuka, K., 1980, Adenylate cyclase activity in thyroid tissue from patients with untreated Graves’ disease, J. Clin. Endocrinol. Metab. 51: 492–499.PubMedCrossRefGoogle Scholar
  221. 221.
    Kuzuya, N., Uchimura, H., Ikeda, H., Chiu, S. C., Hamada, N., Ito, K., and Nagataki, S., 1980, Adenosine 3’,5’-monophosphate concentrations and responsiveness to thyrotropin and thyroid-stimulating immunoglob- ulins in normal and Graves’ thyroids, J. Clin. Endocrinol. Metab. 51: 59–63.PubMedCrossRefGoogle Scholar
  222. 222.
    Drexhage, H. A., Bottazzo, G. F., Doniach, D., Bitensky, L., and Chayen, J., 1980, Evidence for thyroid-growth-stimulating immunoglobulins in some goitrous thyroid diseases, Lancet 2: 287–292.CrossRefGoogle Scholar
  223. 223.
    Takata, I., Suzuki, Y., Saida, K., and Sato, T., 1980, Human thyroid stimulating activity and clinical state in antithyroid treatment of juvenile Graves’ disease, Acta Endocrinol. (Copenhagen) 94: 46–52.Google Scholar
  224. 224.
    Fenzi, G., Hashizume, K., Roudebush, C. P., and DeGroot, L. J., 1979, Changes in thyroid-stimulating immunoglobulins during antithyroid therapy, J. Clin. Endocrinol. Metab. 48: 572–576.PubMedCrossRefGoogle Scholar
  225. 225.
    Teng, C. S., and Yeung, R. T. T., 1980, Changes in thyroid-stimulating antibody activity in Graves’ disease treated with antithyroid drug and its relationship to relapse: A prospective study, J. Clin. Endocrinol. Metab. 50: 144–147.PubMedCrossRefGoogle Scholar
  226. 226.
    McGregor, A. M., Smith, B. R., Hall, R., Petersen, M. M., Miller, M., and Dewar, P. J., 1980, Prediction of relapse in hyperthyroid Graves’ disease, Lancet 1: 1101–1103.PubMedCrossRefGoogle Scholar
  227. 227.
    Zakarija, M., McKenzie, J. M., and Banovac, K., 1980, Clinical significance of assay of thyroid-stimulating antibody in Graves’ disease, Ann. Intern. Med. 93: 28–32.PubMedGoogle Scholar
  228. 228.
    Karlsson, F. A., and Dahlberg, P. A., 1981, Thyroid stimulating antibodies (TSAb) in patients with Graves’ disease undergoing antithyroid drug treatment: Indicators of activity of disease, Clin. Endocrinol. 14: 579–585.CrossRefGoogle Scholar
  229. 229.
    McGregor, A. M., Petersen, M. M., McLachlan, S. M., Rooke, P., Smith, B. R., and Hall, R., 1980, Carbimazole and the autoimmune response in Graves’ disease, N. Engl. J. Med. 303: 302–307.PubMedCrossRefGoogle Scholar
  230. 230.
    McGregor, A. M., Ibbertson, H. K., Smith, B. R., and Hall, R., 1980, Carbimazole and autoantibody synthesis in Hashimoto’s thyroiditis, Br. Med. J. 281: 968–969.PubMedCrossRefGoogle Scholar
  231. 231.
    Hallengren, B., Forsgren, A., and Melander, A., 1980, Effects of antithyroid drugs on lymphocyte function in vitro, J. Clin. Endocrinol. Metab. 51: 298–301.PubMedCrossRefGoogle Scholar
  232. 232.
    Weiss, I., and Davies, T. F., 1981, Inhibition of immunoglobulin-secreting cells by antithyroid drugs, J. Clin. Endocrinol. Metab. 53: 1223–1228.PubMedCrossRefGoogle Scholar
  233. 233.
    Fujiwara, H., Torisu, M., Sugisaki, T., and Okano, H., 1981, Immune complex deposits in thyroid glands of patients with Graves’ disease, Clin. Immunol. Immunopathol. 19: 109–117.PubMedCrossRefGoogle Scholar
  234. 234.
    Ohtaki, S., Endo, Y., Horinouchi, K., Yoshitake, S., and Ishikawa, E., 1981, Circulating thyroglobulin—antithyroglobulin immune complex in thyroid diseases usig enzyme-linked immunoassays, J. Clin. Endocrinol. Metab. 52: 239–246.PubMedCrossRefGoogle Scholar
  235. 235.
    Van der Heide, D., Bolk, J. H., De Bruin, T. W. A., Van Es, L. A., Daha, M. R., Bussemaker, T. K., Goslings, B. M., and Querido, A., 1980, Circulating immune complexes and thyroid-stimulating immunoglobulins before, during, and after antithyroid drug therapy in patients with Graves’ disease, Lancet 1: 1376–1379.PubMedCrossRefGoogle Scholar
  236. 236.
    Jordan, S. C., Johnston, W. H., and Bergstein, J. M., 1978, Immune complex glomerulonephritis mediated by thyroid antigens, Arch. Pathol. Lab. Med. 102: 530–533.PubMedGoogle Scholar
  237. 237.
    Horvath, F., Jr., Teague, P., Gaffney, E. F., Mars, D. R., and Fuller, T. J., 1979, Thyroid antigen associated immune complex glomerulonephritis in Graves’ disease, Am. J. Med. 67: 901–904.PubMedCrossRefGoogle Scholar
  238. 238.
    Jordan, S. C., Buckingham, B., Sakai, R., and Olson, D., 1981, Studies of immune-complex glomerulonephritis mediated by human thyroglobulin, N. Engl. J. Med. 304: 1212–1215.PubMedCrossRefGoogle Scholar
  239. 239.
    Okita, N., Kidd, A., Row, V. V., and Volpe, R., 1980, Sensitization of T-lymphocytes in Graves’ and Hashimoto’s disease, J. Clin. Endocrinol. Metab. 51: 316–320.PubMedCrossRefGoogle Scholar
  240. 240.
    Okita, N., Topliss, D., Lewis, M., Row, V. V., and Volpe, R., 1981, T-lymphocyte sensitization in Graves’ and Hashimoto’s diseases confirmed by an indirect migration inhibition factor test, J. Clin. Endocrinol. Metab. 52: 523–527.PubMedCrossRefGoogle Scholar
  241. 241.
    Okita, N., How, J., Topliss, D., Lewis, M., Row, V. V., and Volpe, R., 1981, Suppressor T lymphocyte dysfunction in Graves’ disease: Role of the H-2 histamine receptor-bearing suppressor T lymphocytes, J. Clin. Endocrinol. Metab. 53: 1002–1007.PubMedCrossRefGoogle Scholar
  242. 242.
    Okita, N., Row, V. V., and Volpe, R., 1981, Suppressor T-lymphocyte deficiency in Graves’ disease and Hashimoto’s thyroiditis, J. Clin. Endocrinol. Metab. 52: 528–533.PubMedCrossRefGoogle Scholar
  243. 243.
    MacLean, D. B., Miller, K. B., Brown, R., and Reichlin, S., 1981, Normal immunoregulation of in vitro antibody secretion in autoimmune thyroid disease, J. Clin. Endocrinol. Metab. 53: 801–805.PubMedCrossRefGoogle Scholar
  244. 244.
    Tanaka, T., Katayama, S., Kuma, K., Tamai, H., Matsuzuka, F., and Hidaka, H., 1980, Clinical and pathological significance of sibling Graves’ disease, Acta Endocrinol. (Copenhagen) 94: 498–502.Google Scholar
  245. 245.
    Banovac, K., Zakarija, M., McKenzie, J. M., Witte, A., and Sekso, M., 1981, Absence of thyroid-stimulating antibody and long acting thyroid stimulator in relatives of Graves’ disease patients, J. Clin. Endocrinol. Metab. 53: 651–653.PubMedCrossRefGoogle Scholar
  246. 246.
    Carey, C., Skosey, C., Pinnamaneni, K. M., Barsano, C. P., and DeGroot, L. J., 1980, Thyroid abnormalities in children of parents who have Graves’ disease: Possible pre-Graves’ disease, Metabolism 29: 369–376.PubMedCrossRefGoogle Scholar
  247. 247.
    Tamai, H., Ohsako, N., Takeno, K., Fukino, O., Takahashi, H., Kuma, K., Kumagai, L. F., and Nagataki, S., 1980, Changes in thyroid function in eu-thyroid subjects with a family history of Graves’ disease: A follow-up study of 69 patients, J. Clin. Endocrinol. Metab. 51: 1123–1127.PubMedCrossRefGoogle Scholar
  248. 248.
    Mather, B. A., Roberts, D. F., Scanlon, M. F., Mukhtar, E. D., Davies, T. F., Smith, B. R., and Hall, R., 1980, HLA antigens and thyroid autoantibodies in patients with Graves’ disease and their first degree relatives, Clin. Endocrinol. 12: 155–163.CrossRefGoogle Scholar
  249. 249.
    Dallow, R. L., 1978, Reliability of orbital diagnostic tests: Ultrasonography, computerized tomography, and radiography, Ophthalmology 85: 1218–1228.PubMedGoogle Scholar
  250. 250.
    Kriss, J. P., and Mehdi, S. Q., 1979, Cell-mediated lysis of lipid vesicles containing eye muscle protein: Implications regarding pathogenesis of Graves’ ophthalmopathy, Proc. Natl. Acad. Sci. USA 76: 2003–2007.PubMedCrossRefGoogle Scholar
  251. 251.
    Sergott, R. C., Felberg, N. T., Savino, P. J., Blizzard, J. J., and Schatz, N. J., 1981, Graves’ ophthalmopathy-immunologic parameters related to corticosteroid therapy, Invest. Ophthalmol. Vis. Sci. 20: 173–182.Google Scholar
  252. 252.
    Teng, C. S., Crombie, A. L., Hall, R., and Ross, W. M., 1980, An evaluation of supervoltage orbital irradiation for Graves’ ophthalmopathy, Clin. Endocrinol. 13: 545–551.CrossRefGoogle Scholar
  253. 253.
    Wall, J. R., Strakosch, C. R., Fang, S. L., Ingbar, S. H., and Braverman, L. E., 1979, Thyroid binding antibodies and other immunological abnormalities in patients with Graves’ ophthalmopathy: Effect of treatment with cyclophosphamide, Clin. Endocrinol. 10: 79–91.CrossRefGoogle Scholar
  254. 254.
    Bigos, S. T., Nisula, B. C., Daniels, G. H., Eastman, R. C., Johnston, H. H., and Kohler, P. O., 1979, Cyclophosphamide in the management of advanced Graves’ ophthalmopathy, Ann. Intern. Med. 90: 921–923.PubMedGoogle Scholar
  255. 255.
    Amino, N., Yuasa, T., Yabu, Y., Miyai, K., and Kumahara, Y., 1980, Exophthalmos in autoimmune thyroid disease, J. Clin. Endocrinol. Metab. 51: 1232–1234.PubMedCrossRefGoogle Scholar
  256. 256.
    Tamai, H., Nakagawa, T., Ohsako, N., Fukino, O., Takahashi, H., Matsuzuka, F., Kuma, K., and Nagataki, S., 1980, Changes in thyroid functions in patients with euthyroid Graves’ disease, J. Clin. Endocrinol. Metab. 50: 108–112.PubMedCrossRefGoogle Scholar
  257. 257.
    Buckingham, B. A., Costin, G., Roe, T. F., Weitzman, J. J., and Kogut, M. D., 1981, Hyperthyroidism in children-A reevaluation of treatment, Am. J. Dis. Child. 135: 112–117.PubMedGoogle Scholar
  258. 258.
    Freitas, J. E., Swanson, D. P., Gross, M. D., and Sisson, J. C., 1979, Iodine-131: Optimal therapy for hyperthyroidism in children and adolescents?, J. Nucl. Med. 20: 847–850.PubMedGoogle Scholar
  259. 259.
    Zonszein, J., Santangelo, R. P., Mackin, J. F., Lee, T. C., Coffey, R. J.,and Canary, J. J., 1979, Propranolol therapy in thyrotoxicosis—A review of 84 patients undergoing surgery, Am. J. Med. 66: 411–416.Google Scholar
  260. 260.
    Rubenfeld, S., Silverman, V. E., Welch, K. M. A., Mallette, L. E., and Kohler, P. O., 1979, Variable plasma propranolol levels in thyrotoxicosis, Med. Intell. 300: 353–354.Google Scholar
  261. 261.
    Riddell, J. G., Neill, J. D., Kelly, J. G., and McDevitt, D. G., 1980, Effects of thyroid dysfunction on propranolol kinetics, Clin. Pharmacol. Ther. 28: 565–574.PubMedCrossRefGoogle Scholar
  262. 262.
    Feely, J., Forrest, A., Gunn, A., Hamilton, W., Stevenson, I., and Crooks, J., 1980, Propranolol dosage in thyrotoxicosis, J. Clin. Endocrinol. Metab. 51: 658–661.PubMedCrossRefGoogle Scholar
  263. 263.
    Feek, C. M., Sawers, J. S. A., Irvine, W. J., Beckett, G. J., Ratcliffe, W. A., and Toft, A. D., 1980, Combination of potassium iodide and propranolol in preparation of patients with Graves’ disease for thyroid surgery, N. Engl. J. Med. 302: 883–885.PubMedCrossRefGoogle Scholar
  264. 264.
    Emerson, C. H., and El-Zaheri, M. M. S., 1980, Potassium iodide and propranolol in Graves’ disease, N. Engl. J. Med. 303: 527–528.PubMedCrossRefGoogle Scholar
  265. 265.
    Feely, J., Crooks, J., Forrest, A. L., Hamilton, W. F. D., Gunn, A., and Browning, M. C. K., 1981, Altered endocrine response to partial thyroidectomy in propranolol-prepared hyperthyroid patients, Clin. Endocrinol. 14: 597–604.CrossRefGoogle Scholar
  266. 266.
    Nilsson, O. R., Melander, A., and Tegler, L., 1980, Effects and plasma levels of propranolol and metoprolol in hyperthyroid patients, Eur. J. Clin. Pharmacol. 18: 315–320.PubMedCrossRefGoogle Scholar
  267. 267.
    Ross, P. J., Jones, M. K., and John, R., 1980, The effect of propranolol withdrawal on thyroid hormones in normal and hyperthyroid subjects, Clin. Endocrinol. 13: 27–31.CrossRefGoogle Scholar
  268. 268.
    Rubin, P. C., 1981, Beta-blockers in pregnancy, N. Engl. J. Med. 305: 1323–1326.PubMedCrossRefGoogle Scholar
  269. 269.
    Bradley, E. L., III, DiGirolamo, M., and Tarcan, Y., 1980, Modified subtotal thyroidectomy in management of Graves’ disease, Surgery 87: 623–629.PubMedGoogle Scholar
  270. 270.
    Rasmusson, B., Borgeskov, S., and Holm-Hansen, B., 1980, Changes in serum calcitonin in patients undergoing thyroid surgery, Surgery 146: 15–17.Google Scholar
  271. 271.
    Wilkin, T. J., Isles, T. E., Gunn, A., Crooks, J., and Beck, J. S., 1979, Short-term triiodothyronine in prevention of temporary hypothyroidism after subtotal thyroidectomy for Graves’ disease, Lancet 2: 63–66.PubMedCrossRefGoogle Scholar
  272. 272.
    Sawers, J. S. A., Toft, A. D., Irvine, W. J., Brown, N. S., and Seth, J., 1980, Transient hypothyroidism after iodine-131 treatment of thyrotoxicosis, J. Clin. Endocrinol. Metab. 50: 226–229.PubMedCrossRefGoogle Scholar
  273. 273.
    Tamai, H., Nakagawa, T., Takahashi, H., Ohsako, N., Fukino, O., Shinzato, R., Suematsu, H., Matsuzuka, F., Kuma, K., and Nagataki, S., 1980, Triiodothyronine suppression tests and TSH-releasing hormone tests before and after 1–131 therapy for Graves’ disease, J. Nucl. Med. 21: 240–245.PubMedGoogle Scholar
  274. 274.
    Vasily, D. B., and Tyler, W. B., 1980, Propylthiouracil-induced cutaneous vasculitis—Case presentation and review of the literature, J. Am. Med. Assoc. 243: 458–461.CrossRefGoogle Scholar
  275. 275.
    Weiss, M., Hassin, D., and Bank, H., 1980, Propylthiouracil-induced hepatic damage, Arch. Intern. Med. 140: 1184–1185.PubMedCrossRefGoogle Scholar
  276. 276.
    Greer, M. A., Kammer, H., and Bouman, D. J., 1977, Short-term antithyroid therapy for the thyrotoxicosis of Graves’ disease, N. Engl. J. Med. 297: 173–176.PubMedCrossRefGoogle Scholar
  277. 277.
    Burr, W. A., Fitzgerald, M. G., and Hoffenberg, R., 1979, Relapse after short-term antithyroid therapy of Graves’ disease, N. Engl. J. Med. 300: 200.PubMedGoogle Scholar
  278. 278.
    Tamai, H., Nakagawa, T., Fukino, O., Ohsako, N., Shinzato, R., Suematsu, H., Kuma, K., Matsuzuka, F., and Nagataki, S., 1980, Thionamide therapy in Graves’ disease: Relation of relapse rate to duration of therapy, Ann. Intern. Med. 92: 488–490.PubMedGoogle Scholar
  279. 279.
    Slingerland, D. W., and Burrows, B. A., 1979, Long-term antithyroid treatment in hyperthyroidism, J. Am. Med. Assoc. 242: 2408–2410.CrossRefGoogle Scholar
  280. 280.
    Wood, L. C., and Ingbar, S. H., 1979, Hypothyroidism as a late sequela in patients with Graves’ disease treated with antithyroid agents, J. Clin. Invest. 64: 1429–1436.PubMedCrossRefGoogle Scholar
  281. 281.
    Yamamoto, M., Igarashi, T., Kimura, S., Tsukamoto, S., Togawa, K., and Ogata, E., 1979, Thyroid suppression test and outcome of hyperthyroidism treated with antithyroid drugs and triiodothyronine, J. Clin. Endocrinol. Metab. 48: 72–77.PubMedCrossRefGoogle Scholar
  282. 282.
    Wilkin, T. J., Isles, T. E., Crooks, J., Gunn, A., and Beck, J. S., 1981, Patterns of change in the early (20-minute) radioiodine uptake during carbimazole treatment for Graves’ disease and their relationship to outcome, J. Clin. Endocrinol. Metab. 52: 1067–1072.PubMedCrossRefGoogle Scholar
  283. 283.
    Gardner, D. F., and Utiger, R. D., 1979, The natural history of hyperthyroidism due to Graves’ disease in remission: Sequential studies of pituitary–thyroid regulation and various serum parameters, J. Clin. Endocrinol. Metab. 49: 417–421.PubMedCrossRefGoogle Scholar
  284. 284.
    Cooper, D. S., Saxe, V. C., Maloof, F., and Ridgway, E. C., 1981, Studies of propylthiouracil using a newly developed radioimmunoassay, J. Clin. Endocrinol. Metab. 52: 204–213.PubMedCrossRefGoogle Scholar
  285. 285.
    Kampmann, J. P., Mortensen, H. B., Bach, B., Waldorff, S., Kristensen, M. B., and Hansen, J. M., 1979, Kinetics of propylthiouracil in the elderly, Acta Med. Scand. 624: 93–98.Google Scholar
  286. 286.
    Skellern, G. G., Knight, B. I., Low, C. K. L., Alexander, W. D., McLarty, D. G., and Kalk, W. J., 1980, The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients, Br. J. Clin. Pharmacol. 9: 137–143.PubMedCrossRefGoogle Scholar
  287. 287.
    Dahlberg, P. A., Karlsson, F. A., Lindström, B., and Wide, L., 1981, Studies of thyroid hormone and methimazole levels in patients with Graves’ disease on a standardized anti-thyroid drug regimen, Clin. Endocrinol. 14: 555–562.CrossRefGoogle Scholar
  288. 288.
    Sugrue, D., McEvoy, M., Feely, J., and Drury, M. I., 1980, Hyperthyroidism in the land of Graves: Results of treatment by surgery, radioiodine and carbimazole in 837 cases, Q. J. Med. 193: 51–61.Google Scholar
  289. 289.
    Reynolds, L. R., and Kotchen, T. A., 1979, Antithyroid drugs and radioactive iodine—Fifteen years’ experience with Graves’ disease, Arch. Intern. Med. 139: 651–653.PubMedCrossRefGoogle Scholar
  290. 290.
    Amir, S. M., Sullivan, R., and Ingbar, S. H., 1981, The effect of desialylation on the in vitro interaction of human chorionic gonadotropin with human thyroid plasma membranes, Endocrinology 109: 1203–1211.PubMedCrossRefGoogle Scholar
  291. 291.
    Carayon, P., Amr, S., Nisula, B., and Lissitzky, S., 1981, Effect of carboxypeptidase digestion of the human choriogonadotropin molecule on its thyrotropic activity, Endocrinology 108: 1891–1898.PubMedCrossRefGoogle Scholar
  292. 292.
    Davies, T. F., Taliadouros, G. S., Catt, K. J., and Nisula, B. C., 1979, Assessment of urinary thyrotropin-competing activity in choriocarcinoma and thyroid disease: Further evidence for human chorionic gonadotropin interacting at the thyroid cell membrane, J. Clin. Endocrinol. Metab. 49: 353–357.PubMedCrossRefGoogle Scholar
  293. 293.
    Pekonen, F., and Weintraub, B. D., 1980, Interaction of crude and pure chorionic gonadotropin with the thyrotropin receptor, J. Clin. Endocrinol. Metab. 50: 280–285.PubMedCrossRefGoogle Scholar
  294. 294.
    Carayon, P., Lefort, G., and Nisula, B., 1980, Interaction of human chorionic gonadotropin and human luteinizing hormone with human thyroid membranes, Endocrinology 106: 1907–1916.PubMedCrossRefGoogle Scholar
  295. 295.
    Nikolai, T. F., Coombs, G. J., and McKenzie, A. K., 1981, Lymphocytic thyroiditis with spontaneously resolving hyperthyroidism and subacute thyroiditis, Arch. Intern. Med. 141: 1455–1458.PubMedCrossRefGoogle Scholar
  296. 296.
    Inada, M., Nishikawa, M., Naito, K., Ishii, H., Tanaka, K., and Imura, H., 1981, Reversible changes of the histological abnormalities of the thyroid in patients with painless thyroiditis, J. Clin. Endocrinol. Metab. 52: 431–435.PubMedCrossRefGoogle Scholar
  297. 297.
    Amino, N., Mori, H., Iwatani, Y., Tanizawa, O., Kawashima, M., Tsuge, I., Ibaragi, K., Kumahara, Y., and Miyai, K., 1982, High prevalence of transient post-partum thyrotoxicosis and hypothyroidism, Med. Intell. 306: 849–852.Google Scholar
  298. 298.
    Amino, N., Yabu, Y., Miki, T., Morimoto, S., Kumahara, Y., Mori, H., Iwatani, Y., Nishi, K., Nakatani, K., and Miyai, K., 1981, Serum ratio of triiodothyronine to thyroxine, and thyroxine-binding globulin and calcitonin concentrations in Graves’ disease and destruction-induced thyrotoxicosis, J. Clin. Endocrinol. Metab. 53: 113–116.PubMedCrossRefGoogle Scholar
  299. 299.
    Weintraub, B. D., Gershengorn, M. C., Kourides, I. A., and Fein, H., 1981, Inappropriate secretion of thyroid-stimulating hormone, Ann. Intern. Med. 95: 339–351.Google Scholar
  300. 300.
    Kourides, I. A., Pekonen, F., and Weintraub, B. D., 1980, Absence of thyroid-binding immunoglobulins in patients with thyrotropin-mediated hyperthyroidism, J. Clin. Endocrinol. Metab. 51: 271–274.CrossRefGoogle Scholar
  301. 301.
    Hamburger, J. I., 1980, Evolution of toxicity in solitary nontoxic autonomously functioning thyroid nodules, J. Clin. Endocrinol. Metab. 50: 1089–1093.PubMedCrossRefGoogle Scholar
  302. 302.
    Mortimer, P. S., Tomlinson, I. W., and Rosenthal, F. D., 1981, Hemiaplasia of the thyroid with thyrotoxicosis, J. Clin. Endocrinol. Metab. 52: 152–155.PubMedCrossRefGoogle Scholar
  303. 303.
    Melnick, J. C., and Stemkowski, P. E., 1981, Thyroid hemiagenesis (hockey stick sign): A review of the world literature and a report of four cases, J. Clin. Endocrinol. Metab. 52: 247–251.PubMedCrossRefGoogle Scholar
  304. 304.
    Sharp, B., Reed, A. W., Tamagna, E. I., Geffner, D. L., and Hershman, J. M., 1981, Treatment of hyperthyroidism with sodium ipodate (Oragrafin) in addition to propylthiouracil and propranolol, J. Clin. Endocrinol. Metab. 53: 622–625.PubMedCrossRefGoogle Scholar
  305. 305.
    Bhasin, S., Wallace, W., Lawrence, J. B., and Lesch, M., 1981, Sudden death associated with thyroid hormone abuse, Am. J. Med. 71: 887–890.PubMedCrossRefGoogle Scholar
  306. 306.
    Nyström, E., Lindstedt, G., and Lundberg, P.-A., 1980, Minor signs and symptoms of toxicity in a young woman in spite of massive thyroxine ingestion, Acta Med. Scand. 207: 135–136.PubMedCrossRefGoogle Scholar
  307. 307.
    Kabadi, U. M., and Eisenstein, A. B., 1980, Glucose intolerance in hyperthyroidism: Role of glucagon, J. Clin. Endocrinol. Metab. 50: 392–396.PubMedCrossRefGoogle Scholar
  308. 308.
    Kabadi, U. M., and Eisenstein, A. B., 1980, Impaired pancreatic a-cell response in hyperthyroidism, J. Clin. Endocrinol. Metab. 51: 478–482.PubMedCrossRefGoogle Scholar
  309. 309.
    Perez, G., Ungaro, B., Covelli, A., Morrone, G., Lombardi, G., Scopacasa, F., and Rossi, R., 1980, Altered glucoregulatory response to physiological infusions of epinephrine and glucagon in hyperthyroidism, J. Clin. Endocrinol. Metab. 51: 972–977.PubMedCrossRefGoogle Scholar
  310. 310.
    Nilsson, O. R., Karlberg, B. E., and Söderberg, A., 1980, Plasma catecholamines and cardiovascular responses to hypoglycemia in hyperthyroidism before and during treatment with metoprolol or propranolol, J. Clin. Endocrinol. Metab. 50: 906–911.PubMedCrossRefGoogle Scholar
  311. 311.
    Tse, J., Wrenn, R. W., and Kuo, J. F., 1980, Thyroxine-induced changes in characteristics and activities of (3-adrenergic receptors and adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate systems in the heart may be related to reputed catecholamine supersensitivity in hyperthyroidism, Endocrinology 107: 6–16.PubMedCrossRefGoogle Scholar
  312. 312.
    Ginsberg, A. M., Clutter, W. E., Shah, S. D., and Cryer, P. E., 1981, Triiodothyronine-induced thyrotoxicosis increases mononuclear leukocyte 3-adrenergic receptor density in man, J. Clin. Invest. 67: 1785–1791.PubMedCrossRefGoogle Scholar
  313. 313.
    Channick, B. J., Adlin, E. V., Marks, A. D., Dennenberg, B. S., McDonough, M. T., Chakko, C. S., and Spann, J. F., 1981, Hyperthyroidism and mitral-valve prolapse, N. Engl.J. Med. 305: 497–500.PubMedCrossRefGoogle Scholar
  314. 314.
    Marks, A. D., Adlin, E. V., Dennenberg, B. S., and Channick, B.J., 1982, Increased incidence of mitral valve prolapse in chronic lymphocytic thyroiditis, Clin. Res. 30: 273A.Google Scholar
  315. 315.
    Bayley, T. A., Harrison, J. E., McNeill, K. G., and Mernagh, J. R., 1980, Effect of thyrotoxicosis and its treatment on bone mineral and muscle mass, J. Clin. Endocrinol. Metab. 50: 916–922.PubMedCrossRefGoogle Scholar
  316. 316.
    Bouillon, R., Muls, E., and De Moor, P., 1980, Influence of thyroid function on the serum concentration of 1,25-dihydroxyvitamin D3, J. Clin. Endocrinol. Metab. 51: 793–797.PubMedCrossRefGoogle Scholar
  317. 317.
    Haldimann, B., Kaptein, E. M., Singer, F. R., Nicoloff, J. T., and Massry, S. G., 1980, Intestinal calcium absorption in patients with hyperthyroidism, J. Clin. Endocrinol. Metab. 51: 995–997.PubMedCrossRefGoogle Scholar
  318. 318.
    Cooper, D. S., Kaplan, M. M., Ridgway, E. C., Maloof, F., and Daniels, G. H., 1979, Alkaline phosphatase isoenzyme patterns in hyperthyroidism, Ann. Intern. Med. 90: 164–168.PubMedGoogle Scholar
  319. 319.
    Wiersinga, W. M., and Touber, J. L., 1980, The relation between gastrin, gastric acid and thyroid function disorders, Acta Endocrinol. (Copenhagen) 95: 341–349.Google Scholar
  320. 320.
    Seino, Y., Miyamoto, Y., Moridera, K., Taminato, T., Matsukura, S., and Imura, H., 1980, The role of the ß-adrenergic mechanism in the hypergastrinemia of hyperthyroidism, J. Clin. Endocrinol. Metab. 50: 368–370.PubMedCrossRefGoogle Scholar
  321. 321.
    Lipson, A., Tah-Hsiung, H., and Nickoloff, E. L., 1980, Blood gastrin levels in hyperthyroidism, J. Clin. Endocrinol. Metab. 50: 176–178.PubMedCrossRefGoogle Scholar
  322. 322.
    Swanson, J. W., Kelly, J. J., Jr., and McConahey, W. M., 1981, Neurologic aspects of thyroid dysfunction, Mayo Clin. Proc. 56: 504–512.PubMedGoogle Scholar
  323. 323.
    Puvanendran, K., Cheah, J. S., Naganathan, N., Yeo, P. P. B., and Wong, P. K., 1979, Neuromuscular transmission in thyrotoxicosis, J. Neurol. Sci. 43: 47–57.PubMedCrossRefGoogle Scholar
  324. 324.
    Rockey, P. H., and Griep, R. J., 1980, Behavioral dysfunction in hyperthyroidism, Arch. Intern. Med. 140: 1194–1197.PubMedCrossRefGoogle Scholar
  325. 325.
    Daneman, D., and Howard, N. J., 1980, Neonatal thyrotoxicosis: Intellectual impairment and craniosynostosis in later years, J. Pediatr. 97: 257–259.PubMedCrossRefGoogle Scholar
  326. 326.
    Hollingsworth, D. R., and Mabry, C. C., 1976, Congenital Graves’ disease, Am. J. Dis. Child. 130: 148.PubMedGoogle Scholar
  327. 327.
    Kidd, G. S., Glass, A. R., and Vigersky, R. A., 1979, The hypothalamic—pituitary—testicular axis in thyrotoxicosis, J. Clin. Endocrinol. Metab. 48: 798–802.PubMedCrossRefGoogle Scholar
  328. 328.
    Gray, R. S., Borsey, D. Q., Seth, J., Herd, R., Brown, N. S., and Clarke, B. F., 1980, Prevalence of subclinical thyroid failure in insulin-dependent diabetes, J. Clin. Endocrinol. Metab. 50: 1034–1037.PubMedCrossRefGoogle Scholar
  329. 329.
    Crowe, J. P., Christensen, E., Butler, J., Wheeler, P., Doniach, D., Keenan, J., and Williams, R., 1980, Primary biliary cirrhosis: The prevalence of hypothyroidism and its relationship to thyroid autoantibodies and sicca syndrome, Gastroenterology 78: 1437–1441.PubMedGoogle Scholar
  330. 330.
    Gordon, M. B., Klein, I., Dekker, A., Rodnan, G. P., and Medsger, T. A., Jr., 1981, Thyroid disease in progressive systemic sclerosis: Increased frequency of glandular fibrosis and hypothyroidism, Ann. Intern. Med. 95: 431–435.PubMedGoogle Scholar
  331. 331.
    Lobo, E. D., Khan, M., and Tew, J., 1980, Community study of hypothyroidism in Down’s syndrome, Br. Med. J. 280: 1253.CrossRefGoogle Scholar
  332. 332.
    Bahn, A. K., Mills, J. L., Snyder, P. J., Gann, P. H., Houten, L., Bialik, O., Hollmann, L., and Utiger, R. D., 1980, Hypothyroidism in workers exposed to polybrominated biphenyls, N. Engl. J. Med. 302: 31–33.PubMedCrossRefGoogle Scholar
  333. 333.
    Smith, R. E., Jr., Adler, R. A., Clark, P., Brinck Johnsen, T., Tulloh, M. E., and Colton, T., 1981, Thyroid function after mantle irradiation in Hodgkin’s disease, J. Am. Med. Assoc. 245: 46–49.CrossRefGoogle Scholar
  334. 334.
    Schimpff, S. C., Diggs, C. H., Wiswell, J. G., Salvatore, P. C., and Wiernik, P. H., 1980, Radiation-related thyroid dysfunction: Implications for the treatment of Hodgkin’s disease, Ann. Intern. Med. 92: 91–98.PubMedGoogle Scholar
  335. 335.
    Dussault, J. H., Letarte, J., Guyda, H., and Laberge, C., 1980, Lack of influence of thyroid antibodies on thyroid function in the newborn infant and on a mass screening program for congenital hypothyroidism, J. Pediatr. 96: 385–389.PubMedCrossRefGoogle Scholar
  336. 336.
    Montoro, M., Collea, J. V., Frasier, S. D., and Mestman, J. H., 1981, Successful outcome of pregnancy in women with hypothyroidism, Ann. Intern. Med. 94: 31–34.Google Scholar
  337. 337.
    Bastenie, P. A., Bonnyns, M., and Vanhaelst, L., 1980, Grades of subclinical hypothyroidism in asymptomatic autoimmune thyroiditis revealed by the thyrotropin-releasing hormone test, Clin. Endocrinol. Metab. 51: 163–166.CrossRefGoogle Scholar
  338. 338.
    Fisher, D. A., Dussault, J. H., Foley, T. P., Jr., Klein, A. H., LaFranchi, S., Lassen, P. R., Michell, M. L., Murphey, W. H., Walfish, P. G., 1979, Screening for congenital hypothyroidism: Results of screening one million North American infants, J. Pediatr. 94: 700–705.PubMedCrossRefGoogle Scholar
  339. 339.
    Landau, H., Sack, J., Frucht, H., Palti, Z., Hochner-Celnikier, D., Rosenmann, A., 1980, Amniotic fluid 3,3’,5’-triiodothyronine in the detection of congenital hypothyroidism, J. Clin. Endocrinol. Metab. 50: 799–801.PubMedCrossRefGoogle Scholar
  340. 340.
    Santos, A. D., Miller, R. P., Mathew, P. K., Wallace, W. A., Cave, W. T., Jr., Hinojosa, L., 1980, Echocardiographic characterization of the reversible cardiomyopathy of hypothyroidism, Am. J. Med. 68: 675–682.PubMedCrossRefGoogle Scholar
  341. 341.
    Plotnick, G. D., Vassar, D. L., Parisi, A. F., Hamilton, B. P., Carliner, N. H., Fisher, M. L. 1979, Systolic time intervals in hypothyroidism: End organ function as a reflection of clinical status, Am. J. Med. Sci. 277: 263–268.PubMedCrossRefGoogle Scholar
  342. 342.
    Sawin, C. T., Chopra, D., Azizi, F., Mannix, J. E., and Bacharach, P., 1979, The aging thyroid, increased prevalence of elevated serum thyrotropin levels in the elderly, J. Am. Med. Assoc. 242: 247–250.CrossRefGoogle Scholar
  343. 343.
    Tieche, M., Lupi, G. A., Gutzwiller, F., Grob, P. J., Studer, H., and Bürgi, H., 1981, Borderline low thyroid function and thyroid autoimmunity, risk factors for coronary heart disease?, Br. Heart J. 46: 202–206.PubMedCrossRefGoogle Scholar
  344. 344.
    Hay, I. D., Duick, D. S., Vlietstra, R. E., Maloney, J. D., and Pluth, J. R., 1981, Thyroxine therapy in hypothyroid patients undergoing coronary revascularization: A retrospective analysis, Ann. Intern. Med. 95: 456–458.PubMedGoogle Scholar
  345. 345.
    Parving, H.-H., Hansen, J. M., Nielsen, S. L., Rossing, N., Munck, O., and Lassen, N. A., 1979, Mechanisms of edema formation in myxedemaIncreased protein extravasation and relatively slow lymphatic drainage, N. Engl. J. Med. 301: 460–465.PubMedCrossRefGoogle Scholar
  346. 346.
    Orr, W. C., Males, J. L., and Imes, N. K., 1981, Myxedema and obstructive sleep apnea, Am. J. Med. 70: 1061–1066.PubMedCrossRefGoogle Scholar
  347. 347.
    Klein, I., Parker, M., Shebert, R., Ayyar, D. R., and Levey, G. S., 1981, Hypothyroidism presenting as muscle stiffness and pseudohypertrophy: Hoffmann’s syndrome, Am. J. Med. 70: 891–894.PubMedCrossRefGoogle Scholar
  348. 348.
    Jakubovic, H. R., Salama, S. S. S., and Rosenthal, D., 1982, Multiple cutaneous focal mucinoses with hypothyroidism, Ann. Intern. Med. 96: 56–58.PubMedGoogle Scholar
  349. 349.
    Amino, N., Kuro, R., Yabu, Y., Takai, S.-I., Kawashima, M., Morimoto, S., Ichihara, K., Miyai, K., and Kumahara, Y., 1981, Elevated levels of circulating carcinoembryonic antigen in hypothyroidism, J. Clin. Endocrinol. Metab. 52: 457–462.PubMedCrossRefGoogle Scholar
  350. 350.
    Agdeppa, D., Macaron, C., Mallik, T., and Schnuda, N. D., 1979, Plasma high density lipoprotein cholesterol in thyroid disease, J. Clin. Endocrinol. Metab. 49: 726–729.PubMedCrossRefGoogle Scholar
  351. 351.
    Gorman, C. A., Jiang, N.-S., Ellefson, R. D., and Elveback, L. R., 1979, Comparative effectiveness of dextrothyroxine and levothyroxine in correcting hypothyroidism and lowering blood lipid levels in hypothyroid patients, J. Clin. Endocrinol. Metab. 49: 1–7.PubMedCrossRefGoogle Scholar
  352. 352.
    Ingbar, J. C., Borges, M., Iflah, S., Kleinmann, R. E., Braverman, L. E., and Ingbar, S. H., 1982, Elevated serum thyroxine concentration in patients receiving “replacement” doses of levothyroxine, J. Endocrinol. Invest. 5: 77–85.PubMedGoogle Scholar
  353. 353.
    Rosenbaum, R. L., and Barzel, U. S., 1982, Levothyroxine replacement dose for primary hypothyroidism decreases with age, Ann. Intern. Med. 96: 53–55.PubMedGoogle Scholar
  354. 354.
    LaFranchi, S. H., 1979, Hypothyroidism, Pediatr. Clin. North Am. 26: 33–51.PubMedGoogle Scholar
  355. 355.
    Studer, H., and Ramelli, F., 1982, Simple goiter and its variants: Euthyroid and hyperthyroid multinodular goiters, Endocr. Rev. 3: 40–61.PubMedCrossRefGoogle Scholar
  356. 356.
    Van Herle, A. J., Rich, P., Ljung, B.-M. E., Ashcraft, M. W., Solomon, D. H., and Keeler, E. B., 1982, The thyroid nodule, Ann. Intern. Med. 96: 221–232.Google Scholar
  357. 357.
    Bolk, J. H., Bussemaker, J. K., Elte, J. W. F., Haak, A., and Van Der Heide, D., 1979, Thyroid-stimulating immunoglobulins do not cause non-autonomous, autonomous, or toxic multinodular goitres, Lancet 2: 61–63.PubMedCrossRefGoogle Scholar
  358. 358.
    Matte, R., Ste-Marie, L. G., Comtois, R., D’Amour, P., Lacroix, A., Chartrand, R., Poisson, R., and Bastomsky, C. H., 1981, The pituitary–thyroid axis after hemithyroidectomy in euthyroid man, J. Clin. Endocrinol. Metab. 53: 377–380.PubMedCrossRefGoogle Scholar
  359. 359.
    Blichert-Toft, M., Egedorf, J., Christiansen, C., and Axelsson, C. K., 1979, Function of pituitary–thyroid axis after surgical treatment of nontoxic nodular goiter, Acta Med. Scand. 206: 15–19.PubMedCrossRefGoogle Scholar
  360. 360.
    McCowen, K. D., Reed, J. W., and Fariss, B. L., 1980, The role of thyroid therapy in patients with thyroid cysts, Am. J. Med. 68: 853–855.PubMedCrossRefGoogle Scholar
  361. 361.
    Rentsch, H., Studer, H., Frauchiger, B., and Siebenhüner, L., 1981, Topographical heterogeneity of basal and thyrotropin-stimulated adenosine 3’,5’-monophosphate in human nodular goiter, J. Clin. Endocrinol. Metab. 53: 514–521.PubMedCrossRefGoogle Scholar
  362. 362.
    Van Sande, J., Mockel, J., Boeynaems, J. M., Dor, P., Andry, G., and Dumont J. E., 1980, Regulation of cyclic nucleotide and prostaglandin formation in normal human thyroid tissue and in autonomous nodules, J. Clin. Endocrinol. Metab. 50: 776–785.PubMedCrossRefGoogle Scholar
  363. 363.
    Nagasaka, A., and Hidaka, H., 1980, Cyclic 3’,5’-nucleotide phosphodiesterase activities in the thyroid glands of patients with various disorders, J. Clin. Endocrinol. Metab. 50: 726–733.PubMedCrossRefGoogle Scholar
  364. 364.
    Saito, K., Yamamota, K., Yoshida, S., Manabe, S., Suzuki, M., Takai, T., Saito, T., Kuzuya, T., and Moriyama, S.-I., 1981, Goitrous hypothyroidism due to iodide-trapping defect, J. Clin. Endocrinol. Metab. 53: 1267–1272.PubMedCrossRefGoogle Scholar
  365. 365.
    Eggo, M. C., Burrow, G. N., Alexander, N. M., and Gordon, J. H., 1980, Iodination and the structure of human thyroglobulin, J. Clin. Endocrinol. Metab. 51: 7–11.PubMedCrossRefGoogle Scholar
  366. 366.
    Cooper, D. S., Axelrod, L., DeGroot, L.J., Vickery, A. Lin, and Maloof, F., 1981, Congenital goiter and the development of metastatic follicular carcinoma with evidence for a leak of nonhormonal iodide: Clinical, pathological, kinetic, and biochemical studies and a review of the literature, J. Clin. Endocrinol. Metab. 52: 294–306.PubMedCrossRefGoogle Scholar
  367. 367.
    Gaitan, E., Medina, P., DeRouen, T. A., and Zia, M. S., 1980, Goiter prevalence and bacterial contamination of water supplies, J. Clin. Endocrinol. Metab. 51: 957–961.PubMedCrossRefGoogle Scholar
  368. 368.
    Weiss, M., Kasper, D., and Ingbar, S. H., 1982, A specific, saturable binding site for thyrotropin (TSH) in Yersinia enterocolitica and E. coli, Clin. Res. 30: 494A.Google Scholar
  369. 369.
    Colacchio, T. A., LoGerfo, P., and Feind, C. R., 1980, Fine needle cytologic diagnosis of thyroid nodules, Am. J. Surg. 140: 568–571.PubMedCrossRefGoogle Scholar
  370. 370.
    Miller, J. M., Hamburger, J. I., and Kini, S., 1979, Diagnosis of thyroid nodules, J. Am. Med. Assoc. 241: 481–484.CrossRefGoogle Scholar
  371. 371.
    Miller, J. M., Hamburger, J. I., and Kini, S. R., 1981, The needle biopsy diagnosis of papillary thyroid carcinoma, Cancer 48: 989–993.PubMedCrossRefGoogle Scholar
  372. 372.
    Stepanas, A. V., Samaan, N. A., Hill, C. S., Jr., and Hickey, R. C., 1979, Medullary thyroid carcinoma, Cancer 43: 825–837.PubMedCrossRefGoogle Scholar
  373. 373.
    Block, M. A., Jackson, C. E., Greenawald, K. A., and Yott, J. B., 1980, Clinical characteristics distinguishing hereditary from sporadic medullary thyroid carcinoma: Treatment implications, Arch. Surg. (Chicago) 115: 142–148.CrossRefGoogle Scholar
  374. 374.
    Lamberg, B.-A., Reissel, P., Stenman, S., Koivuniemi, A., Ekblom, M., Mäkinen, J., and Franssila, K., 1981, Concurrent medullary and papillary thyroid carcinoma in the same thyroid lobe and in siblings, Acta Med. Scand. 209: 421–424.PubMedCrossRefGoogle Scholar
  375. 375.
    Deftos, L. J., Bone, H. G., III, Parthemore, J. G., and Burton, D. W., 1980, Immunohistological studies of medullary thyroid carcinoma and C cell hyperplasia, J. Clin. Endocrinol. Metab. 51: 857–862.PubMedCrossRefGoogle Scholar
  376. 376.
    Schneider, A. B., Bekerman, C., Favus, M., Frohman, L. A., Gonzalez, C., Ryo, U. Y., Sievertsen, G., and Pinsky, S., 1981, Continuing occurrence of thyroid nodules after head and neck irradiation, Ann. Intern. Med. 94: 176–180.Google Scholar
  377. 377.
    McDougall, I. R., Coleman, C. N., Burke, J. S., Saunders, W., and Kaplan, H. S., 1980, Thyroid carcinoma after high-dose external radiotherapy for Hodgkin’s disease, Cancer 45: 2056–2060.PubMedCrossRefGoogle Scholar
  378. 378.
    Compagno, J., and Oertel, J. E., 1980, Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland, Am. J. Clin. Pathol. 74: 1–11.PubMedGoogle Scholar
  379. 379.
    Carayon, P., Morvan, C. T., Castanas, E., and Tubiana, M., 1980, Human thyroid cancer: Membrane thyrotropin binding and adenylate cyclase activity, J. Clin. Endocrinol. Metab. 51: 915–920.PubMedCrossRefGoogle Scholar
  380. 380.
    Schlumberger, M., Charbord, P., Fragu, P., Lumbroso, J., Parmentier, C., and Tubiana, M., 1980, Circulating thyroglobulin and thyroid hormones in patients with metastases of differentiated thyroid carcinoma: Relationship to serum thyrotropin levels, J. Clin. Endocrinol. Metab. 51: 513–519.PubMedCrossRefGoogle Scholar
  381. 381.
    Fui, S. C. N. T., Hoffenberg, R., Maisey, M. N., and Black, E. G., 1979, Serum thyroglobulin concentrations and whole-body radioiodine scan in follow-up of differentiated thyroid cancer after thyroid ablation, Br. Med. J. 2: 298–300.CrossRefGoogle Scholar
  382. 382.
    Ashcraft, M. W., and van Herle, A. J., 1981, The comparative value of serum thyroglobulin measurements and iodine 131 total body scans in the follow-up study of patients with treated differentiated thyroid cancer, Am. J. Med. 71: 806–814.CrossRefGoogle Scholar
  383. 383.
    Schneider, A. B., Line, B. R., Goldman, J. M., and Robbins, J., 1981, Sequential serum thyroglobulin determinations, 131I scans, and 131I uptakes after triiodothyronine withdrawal in patients with thyroid cancer, J. Clin. Endocrinol. Metab. 53: 1199–1206.PubMedCrossRefGoogle Scholar
  384. 384.
    Young, R. L., Mazzaferri, E. L., Rahe, A. J., and Dorfman, S. G., 1980, Pure follicular thyroid carcinoma: Impact of therapy in 214 patients, J. Nucl. Med. 21: 733–737.PubMedGoogle Scholar
  385. 385.
    Mazzaferri, E. L., and Young, R. L., 1981, Papillary thyroid carcinoma: A 10 year follow-up report of the impact of therapy in 576 patients, Am. J. Med. 70: 511–518.CrossRefGoogle Scholar
  386. 386.
    DeGroot, L. J., and Reilly, M., 1982, Comparison of 30- and 50-mCi doses of iodine-131 for thyroid ablation, Ann. Intern. Med. 96: 51–53.PubMedGoogle Scholar
  387. 387.
    Chung, C. T., Sagerman, R. H., Ryoo, M. C., King, G. A., Yu, W. S., Dalai, P. S., and Emmanuel, I. G., 1980, External irradiation for malignant thyroid tumors, Radiology 136: 753–756.PubMedGoogle Scholar
  388. 388.
    Shapiro, S., Slone, D., Kaufman, D. W., Rosenberg, L., Miettinen, O. S., Stolley, P. D., Knapp, R. C., Leavitt, T., Jr., Watring, W. G., Rosenshein, N. B., and Schottenfeld, D., 1980, Use of thyroid supplements in relation to the risk of breast cancer, J. Am. Med. Assoc. 244: 1685–1687.CrossRefGoogle Scholar
  389. 389.
    Hedley, A. J., Spiegelhalter, D. J., Jones, S. J., Clements, P., Bewsher, P. D., Simpson, J. G., and Weir, R. D., 1981, Breast cancer in thyroid disease: Fact or fallacy?, Lancet 1: 131–133.PubMedCrossRefGoogle Scholar
  390. 390.
    Cerbon, M.-A., Pichon, M.-F., and Milgrom, E., 1981, Thyroid hormone receptors in human breast cancer, Cancer Res. 41: 4167–4173.PubMedGoogle Scholar
  391. 391.
    Spitz, I. M., Roith, D. L., Hirsch, H., Carayon, P., Pekonen, F., Liel, Y., Sobel, R., Chorer, Z., and Weintraub, B., 1981, Increased high-molecularweight thyrotropin with impaired biologic activity in a euthyroid man, N. Engl. J. Med. 304: 278–282.PubMedCrossRefGoogle Scholar
  392. 392.
    Beamer, W. G., Eicher, E. M., Maltais, L. J., and Southard, J. L., 1981, Inherited primary hypothyroidism in mice, Science 212: 61–63.PubMedCrossRefGoogle Scholar
  393. 393.
    Smeds, S., Anderberg, B., Boeryd, B., Ericson, L. E., Gillquist, J., and Persliden, J., 1981, The nude mouse: A possible experimental model for investigation of human thyroid tissue, J. Endocrinol. Invest. 4: 11–15.PubMedGoogle Scholar
  394. 394.
    Sternthal, E., Like, A. A., Sarantis, K., and Braverman, L. E., 1981, Lymphocytic thyroiditis and diabetes in the BB/W rat: A new model of autoimmune endocrinopathy, Diabetes 3: 1058–1061.CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Kenneth A. Woeber
    • 1
    • 2
  • Lewis E. Braverman
    • 3
  1. 1.Department of MedicineMt. Zion Hospital and Medical CenterSan FranciscoUSA
  2. 2.University of California School of MedicineSan FranciscoUSA
  3. 3.Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA

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