Sugar Transport in the Renal Epithelial Cell Culture

  • James M. Mullin
  • Arnost Kleinzeller


In 1975, MacKnight, Civan, and Leaf pointed out that any decisive conclusions on possible compartmentation of luminally and antiluminally derived Na+ within the toad bladder epithelial cell were obfuscated by the different cell types encountered in this tissue. Whether the issue is compartmentation within a cell or the existence of multiple transport systems in a cell (e.g., the antiluminal sugar transporters of proximal tubule cells), the endemic problem lies in the assumptions that must be made when examining cellular properties in a tissue preparation. The kidney is particularly troublesome, for here one has not only epithelial and nonepithelial cell types, but a progression of morphologically and/or functionally different transporting epithelia along the nephron, and even within the proximal tubule itself (see, e.g., Woodhall et al., 1978).


Proximal Tubule Sugar Transport Renal Epithelial Cell Epithelial Polarity Kidney Epithelial Cell Line 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • James M. Mullin
    • 1
  • Arnost Kleinzeller
    • 2
  1. 1.Department of Human GeneticsYale University School of MedicineNew HavenUSA
  2. 2.Department of Physiology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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