Complete and Partial Hydatidiform Moles: Cytogenetic and Morphological Aspects

  • A. E. Szulman
  • Urvashi Surti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 176)

Abstract

Although records of molar pregnancies reach back to antiquity, the fetal origin of hydatidiform moles was established only at the end of the last century. The elucidation of the relationship with choriocarcinoma as well as the occurrence of nongestational cancers followed during the next decade (1). Several generations later, many of the mysteries still remain, but new insights in the field of trophoblastic disease are now being gained rapidly, mainly through the study of the chromosomal composition of hydatidiform moles. The latter inquiry into correlation with morphology has allowed the delineation of at least two distinct molar syndromes: the complete, diploid, androgenetic mole of a 46,XX or 46,XY karyotype without an embryo/fetus; and the partial mole with a fetus and a 69,XXY, XXX, or XYY karyotype. Only the classic, complete mole retains at present a known association with chorionic cancer.

Keywords

Oncol Hunt Kato Berman Erythro 

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References

  1. 1.
    Ober, W. B., Historical perspectives on trophoblast and its tumors, Ann. N. Y. Acad. Sci. 80: 3 (1959).PubMedCrossRefGoogle Scholar
  2. 2.
    Hertig, A. T., “Human Trophoblast,” Charles C. Thomas, Springfield, Illinois (1968).Google Scholar
  3. 3.
    Bagshawe, K. D., “Choriocarcinoma: The Clinical Biology of the Trophoblast and Its Tumours,” Arnold, London (1969).Google Scholar
  4. 4.
    Park, W. W., “Choriocarcinoma: A Study of Its Pathology,” Heinemann, London (1971).Google Scholar
  5. 5.
    Fox, H., “Pathology of the Placenta,” W. B. Saunders Co., New York, New York (1978), p. 382.Google Scholar
  6. 6.
    Szulman, A. E. and Surti, U., The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations, Amer. J. Obstet. Gynecol. 131: 665 (1978).Google Scholar
  7. 7.
    Szulman, A. E. and Surti, U., The syndromes of hydatidiform mole. II. Morphologic evolution of the complete and partial mole, Amer. J. Obstet. Gynecol. 132: 20 (1978).Google Scholar
  8. 8.
    Elston, C. W., The histopathology of trophoblastic tumours, J. Clin. Pathol. 29 (Suppl., Royal College of Pathology 10): 111 (1976).CrossRefGoogle Scholar
  9. 9.
    Jacobs, P. A., Human chromosome heteromorphisms (variants), Progr. Med. Genetics 2: 252 (1977).Google Scholar
  10. 10.
    Kajii, T. and Ohama, K., Androgenetic origin of hydatidiform mole, Nature 268: 633 (1977).PubMedCrossRefGoogle Scholar
  11. 11.
    Jacobs, P. A., Wilson, C., Sprenkle, J., et al., Mechanism of origin of complete hydatidiform moles, Nature 286: 714 (1980).PubMedCrossRefGoogle Scholar
  12. 12.
    Lawler, D., Povey, T., Fisher, A., and Pickthall, J., Genetic studies on hydatidiform mole II. The origin of complete moles, Ann. Human Genetics 46: 232 (1982).CrossRefGoogle Scholar
  13. 13.
    Yamashita, K., Wake, N., Tsuneo, A., et al., A further HLA study of hydatidiform moles, Gynecol. Oncol. 11: 238 (1981).Google Scholar
  14. 14.
    Surti, U., Szulman, A., and O’Brien, S., Complete (classic) hydatidiform mole, with 46,XY daryotype, of paternal origin, Human Genetics 51: 153 (1979).PubMedCrossRefGoogle Scholar
  15. 15.
    Ohama, K., Kajii, T., Okamoto, E., et al., Dispermic origin of XY hydatidiform moles, Nature 292: 551 (1981).PubMedCrossRefGoogle Scholar
  16. 16.
    Surti, U., Szulman, A. E., and O’Brien, S., Dispermic origin and clinical outcome of three complete hydatidiform moles with 46,XY karyotype, Amer. J. Obstet. Gynecol. 144: 84 (1982).Google Scholar
  17. 17.
    Pattillo, R. A., Sasaki, S., Katayama, K. P., Roessler, M., and Mattingly, R. F., Genesis of 46,XY hydatidiform mole, Amer. J. Obstet. Gynecol. 141: 104 (1981).Google Scholar
  18. 18.
    Beischer, N. A., Hydatidiform mole with co-existent foetus, J. Obstet. Gynaecol. Brit. Emp. 68: 231 (1961).CrossRefGoogle Scholar
  19. 19.
    Vassilakos, P., Riotton, G., and Kajii, T., Hydatidiform mole: Two entities, Amer. J. Obstet. Gynecol. 127: 167 (1977).Google Scholar
  20. 20.
    Szulman, A. E., Phillippe, E., Boue, J. G., and Boue, A., Human triploidy: Association with partial hydatidiform moles and nonmolar conceptuses, Human Pathology 12: 1016 (1981).PubMedCrossRefGoogle Scholar
  21. 21.
    Jacobs, P. A., Szulman, A. E., Hunt, P., et al., Complete and partial hydatidiform mole in Hawaii, Brit. J. Obstet. Gynecol. 89: 258 (1982).CrossRefGoogle Scholar
  22. 22.
    Jacobs, P. A., Szulman, A. E., Funkhouser, J., et al., Human triploidy: Relationship between parental origin of chromosomes and development of partial mole in the placenta, Ann. Human Genetics 46: 233 (1982).CrossRefGoogle Scholar
  23. 23.
    Lawler, D., Fisher, R. A., Pickthall, et al., Origin of hydatidiform moles, I: Origin of partial moles, Cancer Gen. and Cytogenetics 5: 309 (1982).CrossRefGoogle Scholar
  24. 24.
    Philippe, E., “Pathologic Placentaire,” Masson and Cre, Paris (1974).Google Scholar
  25. 25.
    Szulman, A. E. and Surti, U., The clinicopathologic profile of the partial hydatidiform mole, Obstet. Gynecol. 59: 597 (1982).Google Scholar
  26. 26.
    Szulman, A. E., Surti, U., and Berman, M., Patient with partial mole requiring chemotherapy, Lancet 2: 1009 (1978).Google Scholar
  27. 27.
    Berkowitz, R. S., Goldstein, D. P., Marean, A. R., et al., Proliferative sequelae after evacuation of partial hydatidiform mole, Lancet 2: 804 (1979).PubMedCrossRefGoogle Scholar
  28. 28.
    Szulman, A. E., Ma, H. K., Wong, L. C., and Hsu, C., Residual trophoblastic disease in association with partial hydatidiform mole, Obstet. Gynecol. 57: 392 (1981).PubMedGoogle Scholar
  29. 29.
    Bagshawe, K. D., Wilson, H., Dublon, et al., Follow-up after hydatidiform mole, J. Obstet. Gynecol. Brit. Cmwth. 80: 461 (1973).CrossRefGoogle Scholar
  30. 30.
    Ring, A. M., The concept of benign metastasizing hydatidiform moles, Amer. J. Clin. Pathol. 58:111. (1972).Google Scholar
  31. 31.
    Johnson, T., Comstock, C., and Anderson, D., Benign gestational trophoblastic disease metastatic to pleura: Unusual cause of hemothorax, Obstet. Gynecol. 53: 509 (1979).Google Scholar
  32. 32.
    Kato, M., Tanaka, K., and Takeuchi, S., The nature of trophoblastic disease initiated by transplantation into immunosuppressed animal, Amer. J. Obstet. Gynecol. 142: 497 (1982).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. E. Szulman
    • 1
  • Urvashi Surti
    • 1
  1. 1.Department of Pathology Magee-Womens Hospital and School of MedicineUniversity of PittsburghPittsburghUSA

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