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First World Congress on Trophoblast Neoplasms

  • R. S. Berkowitz
  • S. J. Lahey
  • G. SteeleJr.
  • A. A. Rayner
  • M. L. Rodrick
  • D. P. Goldstein
  • R. Harahap
  • R. A. Pattillo
  • S. Sasaki
  • K. P. Katayama
  • M. Roesler
  • R. F. Mattingly
  • D. P. Goldstein
  • R. S. Berkowitz
  • P. K. Zucker
  • M. R. Bernstein
  • H. Salari
  • V. Partovie
  • M. W. Shin
  • Ch. V. Rao
  • R. O. Hussa
  • F. R. CarmanJr.
  • M. L. Rinke
  • C. L. Cook
  • M. A. Yussman
  • H. Zakut
  • A. Ludomirsky
  • L. A. Cole
  • S. K. Sutphen
  • R. O. Hussa
  • R. A. Pattillo
  • S. J. Kim
  • B. C. Kang
  • J. K. Jung
  • J. W. Lee
  • C. B. Sekadde-Kigondu
  • J. K. G. Mati
  • A. E. Mokohka
  • F. B. Fongoh
  • R. M. Lequin
  • T. Tanaka
  • H. Ito
  • T. Hosokawa
  • R. A. Elegbe
  • R. O. Hussa
  • R. A. Pattillo
  • I. O. Damole
  • R. G. Hoffmann
  • W. Finlayson
  • W. B. Jones
  • G. W. Stanimir
  • J. L. LewisJr.
  • R. S. Berkowitz
  • D. P. Goldstein
  • J. Birnholz
  • D. P. Goldstein
  • R. S. Berkowitz
  • M. R. Bernstein
  • C. T. Hsu
  • M. Sarram
  • H. Baja-Panlilio
  • A. M. Lopez
  • I. C. Huy
  • E. J. Aartsen
  • F. B. Lammes
  • M. J. ten Kate Booy
  • Heung Tat Ng
  • V. Partovi
  • H. Salari
  • G. H. Nassirai
  • Djamhoer Martaadisoebrata
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 176)

Abstract

Circulating immune complex (CIC) levels were measured by a polyethylene glycol turbidity assay in patients with molar pregnancy to investigate the relationship between CIC and trophoblastic tumor burden. At the time of presentation, CIC values were in normal range in 27 (87%) of 31 patients with molar pregnancy. Three of the four patients who presented with elevated CIC levels had concurrent medical illness (toxemia, hepatitis, and renovascular hypertension). Eighteen patients were followed with serial CIC measurements until they achieved gonadotropin remission and all 18 patients developed increased levels as they entered remission (P<0.001). As patients approach gonadotropin remission, a decreasing antigen load may provide a more favorable antigen-antibody ratio for the formation and detection of CIC. CIC values remained elevated during remission from 6 to 16 weeks (mean = 11.5 weeks) and then declined to presentation levels. In one patient, serum obtained at the time of peak CIC levels was concentrated, fractionated and characterized to identify the antigen components in the immune complexes. Importantly, this patient had only conceived two prior molar pregnancies and had received no blood product transfusions. One of the paternal HLA haplotypes (AW32) was demonstrated to be an antigen component in the maternal immune complexes. Further investigation should be undertaken to evaluate possible interactions between CIC and host immune defenses.

Keywords

Hydatidiform Mole Circulate Immune Complex Gestational Trophoblastic Disease Molar Pregnancy Trophoblast Neoplasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. S. Berkowitz
    • 1
  • S. J. Lahey
    • 1
  • G. SteeleJr.
    • 1
  • A. A. Rayner
    • 1
  • M. L. Rodrick
    • 1
  • D. P. Goldstein
    • 1
  • R. Harahap
    • 2
  • R. A. Pattillo
    • 3
  • S. Sasaki
    • 3
  • K. P. Katayama
    • 3
  • M. Roesler
    • 3
  • R. F. Mattingly
    • 3
  • D. P. Goldstein
    • 4
  • R. S. Berkowitz
    • 4
  • P. K. Zucker
    • 4
  • M. R. Bernstein
    • 4
  • H. Salari
    • 5
  • V. Partovie
    • 5
  • M. W. Shin
    • 6
  • Ch. V. Rao
    • 7
  • R. O. Hussa
    • 8
  • F. R. CarmanJr.
    • 7
  • M. L. Rinke
    • 8
  • C. L. Cook
    • 7
  • M. A. Yussman
    • 7
  • H. Zakut
    • 9
  • A. Ludomirsky
    • 9
  • L. A. Cole
    • 8
  • S. K. Sutphen
    • 8
  • R. O. Hussa
    • 8
  • R. A. Pattillo
    • 8
  • S. J. Kim
    • 10
  • B. C. Kang
    • 10
  • J. K. Jung
    • 10
  • J. W. Lee
    • 10
  • C. B. Sekadde-Kigondu
    • 11
  • J. K. G. Mati
    • 11
  • A. E. Mokohka
    • 11
  • F. B. Fongoh
    • 11
  • R. M. Lequin
    • 11
  • T. Tanaka
    • 12
  • H. Ito
    • 12
  • T. Hosokawa
    • 12
  • R. A. Elegbe
    • 13
  • R. O. Hussa
    • 13
  • R. A. Pattillo
    • 13
  • I. O. Damole
    • 14
  • R. G. Hoffmann
    • 13
  • W. Finlayson
    • 13
  • W. B. Jones
    • 15
  • G. W. Stanimir
    • 15
  • J. L. LewisJr.
    • 15
  • R. S. Berkowitz
    • 16
  • D. P. Goldstein
    • 16
  • J. Birnholz
    • 16
  • D. P. Goldstein
    • 17
    • 18
  • R. S. Berkowitz
    • 17
    • 18
  • M. R. Bernstein
    • 17
    • 18
  • C. T. Hsu
    • 19
  • M. Sarram
    • 20
  • H. Baja-Panlilio
    • 21
  • A. M. Lopez
    • 22
  • I. C. Huy
    • 22
  • E. J. Aartsen
    • 23
  • F. B. Lammes
    • 24
  • M. J. ten Kate Booy
    • 24
  • Heung Tat Ng
    • 25
  • V. Partovi
    • 26
  • H. Salari
    • 26
  • G. H. Nassirai
    • 26
  • Djamhoer Martaadisoebrata
    • 27
  1. 1.New England Trophoblastic Disease Center Departments of Obstetrics and Gynecology and SurgeryBrigham and Women’s Hospital Harvard Medical SchoolBostonUSA
  2. 2.University of IndonesiaJakartaIndonesia
  3. 3.Department of Gynecology and ObstetricsThe Medical College of WisconsinMilwaukeeUSA
  4. 4.New England Trophoblastic Disease Center Division of Gynecologic Oncology Department of Obstetrics and GynecologyHarvard Medical School Brigham and Women’s HospitalBostonUSA
  5. 5.Ghem Medical CenterMeshed UniversityMeshedIran
  6. 6.Department of Obstetrics and Gynecology College of MedicineSeoul National UniversitySeoulKorea
  7. 7.Department of Obstetrics and Gynecology Midcontinental Institute for Trophoblastic DiseaseUniversity of LouisvilleLouisvilleUSA
  8. 8.Department of Gynecology and ObstetricsMedical College of WisconsinMilwaukeeUSA
  9. 9.Department of Obstetrics and Gynecology The Edith Wolfson Hospital Sackler School of MedicineTel-Aviv UniversityHolonIsrael
  10. 10.Department of Gynecology and ObstetricsMedical College of WisconsinMilwaukeeUSA
  11. 11.Department of Obstetrics and GynecologyCatholic Medical SchoolSeoulKorea
  12. 12.Department of Obstetrics and GynecologyUniversity of NairobiNairobiKenya
  13. 13.Department of Obstetrics and GynecologyThe Jikei University School of MedicineTokyoJapan
  14. 14.Dept. of Ob/GynUniversity of IbadanIbadanNigeria
  15. 15.Memorial Institute-Sloane KetteringColumbia UniversityNew YorkUSA
  16. 16.New England Trophoblast Disease Center Harvard Medical SchoolBrigham and Women’s HospitalBostonUSA
  17. 17.New England Trophoblastic Disease Center Division of Gynecologic OncologyBrigham and Women’s HospitalBostonUSA
  18. 18.Department of Obstetrics and GynecologyHarvard Medical SchoolBostonUSA
  19. 19.TaipeiTaiwan Republic of China
  20. 20.University of Isfahan Medical School and the Center for Population StudiesUniversity of IsfahanIsfahanIran
  21. 21.University of the East Medical CenterJose Fabella Memorial Hospital Ministry of HealthManilaPhilippines
  22. 22.Childrens Medical CenterBanawe, Quezon CityPhilippines
  23. 23.Netherlands Cancer InstituteAmsterdamThe Netherlands
  24. 24.Wilhelmina GasthuisAmsterdamThe Netherlands
  25. 25.Veterans General HospitalTaipeiTaiwan
  26. 26.Ghaem Medical CenterMeshed UniversityMeshedIran
  27. 27.Department of Obstetrics and Gynecology School of MedicinePadjadjaran UniversityBandungIndonesia

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