Management of Patients with Gestational Trophoblastic Neoplasia: Experience of the Southeastern Regional Center

  • Charles B. Hammond
  • Daniel L. Clarke-Pearson
  • John T. Soper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 176)


Gestational trophoblastic neoplasia (GTN), a group of the more virulent malignant tumors in humans, is derived from the trophoblast of human pregnancy. Prior to 1956, the prognosis for these patients was exceedingly poor, regardless of the surgical or irradiation therapies utilized (1). Since that time and the advent of systemic chemotherapy as the primary therapeutic modality for these patients, results have become exceedingly good (2). Sequential reports have been published documenting increasingly good remission rates (3–6). Cure rates now approach 100% for patients without metastases and those with “good” prognosis metastatic disease. Even in patients with “poor” prognosis GTN, high rates of remission have been achieved with vigorous multi-modality therapy.


Hydatidiform Mole Gestational Trophoblastic Disease Trophoblastic Tumor Gestational Trophoblastic Neoplasia Invasive Mole 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Charles B. Hammond
    • 1
  • Daniel L. Clarke-Pearson
    • 1
  • John T. Soper
    • 1
  1. 1.The Southeastern Regional Center for Trophoblastic Disease Department of Obstetrics and GynecologyDuke University Medical CenterDurhamUSA

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