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Re-Evaluation of 5-Fluorouracil as a Single Agent for Gestational Malignant Trophoblastic Neoplasms

  • Hung-Chao Sung
  • Pao-Chen Wu
  • Yuan-Bh Wang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 176)

Abstract

It has been more than 20 years since 6-mercaptopurine was successfully used for the first time in the treatment of malignant trophoblastic neoplasms in the Capital Hospital in 1958. Since then, a total of four effective drugs have been found, and a dramatic improvement in prognosis of the patients has been achieved, resulting in permanent cure of this group of tumors. The overall results of treatment were reported in 1979 (1). To provide a general principle for the selection of a proper chemotherapeutic agent for clinical use, it is mandatory to evaluate each drug individually. The purpose of this paper is to present the therapeutic results of 5-fluorouracil used as a single agent in the treatment of malignant trophoblastic neoplasms.

Keywords

Complete Remission Single Agent Remission Rate Partial Remission Bone Marrow Suppression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sung, H. C., Xia, Z. F., Wu, P. C., and Wang, Y. E., 20 years experience in chemotherapy of choriocarcinoma and malignant mole, Chinese Medical Journal 92: 677 (1979).Google Scholar
  2. 2.
    Sung, H. C., Wu, P. C., and Ho, T. H., Treatment of choriocar- cinoma and chorioadenoma destruens with 6MP and surgery, a clinical report of 67 cases, in: “Selected Papers on Cancer Research,” edited by Chinese Academy of Medical Sciences, Shanghai Sci. Tech. Publ. (1962), p. 441; republished in Acta Unio Inter-nationalis Contra Cancerum 20:491 (1964).Google Scholar
  3. 3.
    Zubrod, C. G., Effects of 5FU and 5FUDR on G-I cancer, J. Amer. Med. Assoc. 178: 832 (1961).CrossRefGoogle Scholar
  4. 4.
    Sullivan, R. D., “Clinical Cancer Chemotherapy Including Ambulatory Infusion,” Charles C. Thomas, Publisher, Springfield, III. (1970), p. 50, p. 87.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Hung-Chao Sung
    • 1
  • Pao-Chen Wu
    • 1
  • Yuan-Bh Wang
    • 1
  1. 1.Department of Obstetrics and Gynecology Capital HospitalChinese Academy of Medical SciencesPekingChina

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