Paradoxical Effect of Antibodies Against Chorionic Gonadotropin on BeWo Choriocarcinoma Cells in Vitro and in Vivo: Evidence for Heterogeneity of Cell Types

  • S. K. Gupta
  • G. P. Talwar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 176)


Human chorionic gonadotropin (hCG), a major hormone of early pregnancy, is also secreted by a variety of trophoblastic and nontrophoblastic tumors (1–3). Anti-hCG immunization has been proposed as an approach for control of fertility (4–6). The impact of anti-hCG immunization on tumors making hCG is a matter of concern. The antibodies could have an enhancing effect as noticed for some tumors (7), or could exercise a cytotoxic action on cancer cells secreting this hormone, especially in view of the report on localization of hCG on the surface of tumor cells (8).


Human Chorionic Gonadotropin Tetanus Toxoid Paradoxical Effect BeWo Cell Hamster Cheek Pouch 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • S. K. Gupta
    • 1
  • G. P. Talwar
    • 1
  1. 1.Department of BiochemistryAll India Institute of Medical Sciences and National Institute of ImmunologyNew DelhiIndia

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