Gluconeogenesis, Cytosolic Redox Potential, and Phosphate and Fluid Transport in the Isolated Rabbit Proximal Tubule

  • Norimoto Yanagawa
  • Glenn T. Nagami
  • Kiyoshi Kurokawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


Gluconeogenesis (GNG) in the kidney represents an important metabolic activity localized to the proximal tubules (1). It has been suggested that renal GNG may play a key role in the regulation of renal ammoniagenesis in metabolic acidosis (2) and also may contribute to blood glucose concentrations (3). However, it is not known whether renal GNG serves any functional role in solute and fluid transport in the proximal nephron. Recent observations from several laboratories suggested that GNG may play some role in the regulation of fluid and inorganic phosphate (Pi) reabsorption in the proximal tubule. For example, Dousa and associates proposed that cytosolic concentrations of the oxidized form of nicotinamide adenine dinucleotide (NAD+) may control proximal Pi reabsorption and as such GNG may modulate Pi transport through altering the cytosolic level of NAD+ (4). Silva and colleagues, who studied isolated perfused rat kidney, suggested that GNG and sodium reabsorption may compete for the common energy source, resulting in reciprocal changes in the rates of GNG and fluid reabsorption in the proximal tubules (5,6).


Methylene Blue Proximal Tubule Brush Border Membrane Brush Border Membrane Vesicle Renal Brush Border Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Norimoto Yanagawa
    • 1
    • 2
  • Glenn T. Nagami
    • 1
    • 2
  • Kiyoshi Kurokawa
    • 1
    • 2
  1. 1.Nephrology DivisionsMedical and Research Services Veterans Administration Sepulveda and Wadsworth HospitalsUSA
  2. 2.Department of MedicineUniversity of California at Los Angeles (UCLA) School of MedicineLos AngelesUSA

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