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Role of c-AMP and NAD in the Regulation of Na+-Dependent Phosphate Transport Across Rat Renal Brush Border Membranes

  • Jürg Biber
  • Piotr Gmaj
  • Kerstin Malmström
  • Heini Murer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

The activity of the sodium-dependent Pi-transport system in the brush border membrane changes in concordance with the tubular phosphate reabsorption under a variety of physiological conditions (Dousa and Kempson, 1982). Two mechanisms were postulated to be involved in these adaptations: a cyclic-AMP dependent phosphorylation of brush border membrane protein(s) (Hammerman and Hruska, 1982) and a direct interaction of NAD with the membrane (Kempson et al., 1981), apparently via a ADP-ribosylation of certain membrane proteins (Hammerman et al., 1982).

Keywords

Brush Border Membrane Osmotic Shock Brush Border Membrane Vesicle Isotonic Condition Hypotonic Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Jürg Biber
    • 1
  • Piotr Gmaj
    • 1
  • Kerstin Malmström
    • 1
  • Heini Murer
    • 1
  1. 1.Institute of PhysiologyUniversity of ZürichZürichSwitzerland

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