Role of c-AMP and NAD in the Regulation of Na+-Dependent Phosphate Transport Across Rat Renal Brush Border Membranes
The activity of the sodium-dependent Pi-transport system in the brush border membrane changes in concordance with the tubular phosphate reabsorption under a variety of physiological conditions (Dousa and Kempson, 1982). Two mechanisms were postulated to be involved in these adaptations: a cyclic-AMP dependent phosphorylation of brush border membrane protein(s) (Hammerman and Hruska, 1982) and a direct interaction of NAD with the membrane (Kempson et al., 1981), apparently via a ADP-ribosylation of certain membrane proteins (Hammerman et al., 1982).
KeywordsBrush Border Membrane Osmotic Shock Brush Border Membrane Vesicle Isotonic Condition Hypotonic Treatment
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