Renal Brush Border Membranes in X-Linked Hypophosphatemic Mice: A Study of the Protein Kinase Activity
A few years ago Tenenhouse et al. (1), reported that phosphate (PO4) uptake by renal brush border membrane (BBM) vesicles from hypophosphatemic mice (Hyp) was half that of normal. Thus, the defect in uptake observed in vitro reflects the defect of PO4 reabsorption in vivo (2, 3). This modification of the BBM responsible for the decreased uptake of PO4 does not interfere with its adaptation to PO4 deprivation (4), although this adaptation remains incomplete (5), nor does it with the normal response to parathyroidectomy (3).
KeywordsBrush Border Membrane Apparent Molecular Weight Brush Border Membrane Vesicle Hypophosphatemic Rickets Renal Brush Border Membrane
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