Impaired Hormonal Stimulation in Isolated Hepatocytes of Phosphorous Depleted Rats
Clinical evidence has been presented for disturbed liver function in patients with phosphorous depletion and hypophosphatemia 1. Rajan et al.2 emphasized that hypophosphatemic patients with cirrhosis tend to undergo greater hepatic decompensation than do patients with normal blood phosphorous. Furthermore, Klock et al.3 found a defective hyperglycemic response to glucagon in alcoholic patients with hypophosphatemia. This abnormality was completely normalized after restoration of serum phosphorous levels. These observations were made in intact organism. Consequently, it cannot be decided whether hepatic cell function is altered or whether these changes are secondary to circulatory problems, altered tissue oxygenation 4 or altered hormone metabolism.
KeywordsGlucose Production Hepatic Coma Serum Phosphorous Level cAMP Content Phosphate Depletion
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