Effect of Calcitriol on Serum 1,25(OH) 2D3 Levels and on Renal Phosphorous Threshold in X-Linked Hypophosphatemic Rickets
Renal hypophosphatemic rickets is characterized by sustained hypophosphatemia due to a reduction in renal tubular reabsorption of phosphate which leads to severe growth retardation and ricketic bone disease. Normal (1) but also subnormal (2) calcitriol serum levels have been reported in X-linked hypophosphatemic rickets (XLH). Nevertheless one does not know from the literature, whether low 1,25(OH)2D3 levels are the consequence of pretreatment with vitamin D3 and phosphorous or not.
KeywordsHypophosphatemic Rickets Phosphate Loading Renal Tubular Reabsorption Phosphate Supplement Severe Growth Retardation
Unable to display preview. Download preview PDF.
- 4.Glorieux, F.H., Marie, P.J., Pettifor, J.M.: Bone response to phosphate salts, ergocalciferol and caicitriol in hypophosphatemic vitamin D-resistant rickets.New Engl. J. Med. 303, 1023, 1980Google Scholar
- 5.Scriver, C.R., Reade, T.M., DeLuca, H.F.: Serum 1,25-dihydroxyvitamin D levels in normal subjects and in patients with hereditary rickets or bone disease.New Engl. J. Med. 299, 976–979, 1978Google Scholar