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Effect of Calcitriol on Serum 1,25(OH) 2D3 Levels and on Renal Phosphorous Threshold in X-Linked Hypophosphatemic Rickets

  • O. Mehls
  • F. Manz
  • K. Kettenmann
  • J. P. Bonjour
  • U. Trechsel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

Renal hypophosphatemic rickets is characterized by sustained hypophosphatemia due to a reduction in renal tubular reabsorption of phosphate which leads to severe growth retardation and ricketic bone disease. Normal (1) but also subnormal (2) calcitriol serum levels have been reported in X-linked hypophosphatemic rickets (XLH). Nevertheless one does not know from the literature, whether low 1,25(OH)2D3 levels are the consequence of pretreatment with vitamin D3 and phosphorous or not.

Keywords

Hypophosphatemic Rickets Phosphate Loading Renal Tubular Reabsorption Phosphate Supplement Severe Growth Retardation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lyles, K.W., Clark, A.G., Drezner, M.K.:Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia. Calcif. Tissue Int. 34, 125–130, 1982PubMedCrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • O. Mehls
    • 1
    • 2
  • F. Manz
    • 1
    • 2
  • K. Kettenmann
    • 1
    • 2
  • J. P. Bonjour
    • 1
    • 2
  • U. Trechsel
    • 1
    • 2
  1. 1.Department of PediatricsUniversity of HeidelbergGermany
  2. 2.Dept. of PathophysiologyUniversity of BernSwitzerland

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