Parathyroid Hormone (PTH) Status and Phosphate (Pi) Transport in Proximal Brush Border Membrane Vesicles (BBMV) and Whole Kidney

  • J. Caverzasio
  • J. P. Bonjour
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


PTH and dietary Pi are independent factors which influence the tubular Pi reabsorptive capacity as assessed by determining the maximal tubular reabsorption of Pi per volume of glomerular filtrate (max. TRPi/ml GF) (1). Both factors can also alter the Na+-dependent Pi transport system located in the luminal membrane of the proximal tubule (2, 3). In the situation of Pi restriction, plasma PTH level is markedly decreased as compared to normal Pi feeding (4).


Brush Border Membrane Vesicle Luminal Membrane Renal Brush Border Membrane Renal Cortical Slice Renal Brush Border Membrane Vesicle 
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  1. 1.
    Troehler, U., Bonjour J.P., and Fleisch, H., 1976, Inorganic phosphate homeostasis: Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats, J.Clin.Invest. 57: 264.CrossRefGoogle Scholar
  2. 2.
    Stoll, R., Kinne, R., Murer, H., Fleisch, H., and Bonjour, J.P., 1979, Phosphate transport by rat renal brush border membrane vesicles: Influence of dietary phosphate, thyroparathyroidectomy and 1,25 dihydroxyvitamin D3, Pflügers Arch. 380: 47–52.PubMedCrossRefGoogle Scholar
  3. 3.
    Evers, C., Murer, H., and Kinne, R., 1978, Effect of parathyrin on the transport properties of isolated renal brush border vesicles. Biochem. J. 172: 49–56PubMedGoogle Scholar
  4. 4.
    Freudiger, H., Caverzasio, J., Fischer, J., Trechsel, U. and Bonjour, J.P., Urinary cyclic AMP and parathyroid hormone status in rats with intact and reduced renal mass. Manuscript in preparation.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. Caverzasio
    • 1
    • 2
  • J. P. Bonjour
    • 1
    • 2
  1. 1.Department of PathophysiologyUniversity of BerneSwitzerland
  2. 2.Division of Pathophysiology, Department of MedicineUniversity of GenevaSwitzerland

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