Abnormalities in Parathyroid Hormone Secretion in Primary and Secondary Hyperparathyroidism

  • Jeremiah Morrissey
  • Kevin Martin
  • Keith Hruska
  • Eduardo Slatopolsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


High levels of serum parathyroid hormone are present in patients with primary and secondary hyperparathyroidism. In primary hyperparathyroidism, approximately 90% of the patients have an adenoma of the parathyroid glands and hypercalcemia is usually seen in this disorder. On the other hand, patients with secondary hyperparathyroidism have hyperplasia of all four parathyroid glands and hypocalcemia. Although in the two above-described abnormalities the amount of parathyroid tissue is enlarged and the secretion of PTH increased, it will seem that other mechanisms also are involved in the abnormal secretion of PTH observed in these patients.


Parathyroid Hormone Parathyroid Gland Hormone Secretion Secondary Hyperparathyroidism Parathyroid Tissue 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Jeremiah Morrissey
    • 1
  • Kevin Martin
    • 1
  • Keith Hruska
    • 1
  • Eduardo Slatopolsky
    • 1
  1. 1.Renal Division, Department of MedicineWashington University School of MedicineSt. LouisUSA

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