Abnormalities in Parathyroid Hormone Secretion in Primary and Secondary Hyperparathyroidism
High levels of serum parathyroid hormone are present in patients with primary and secondary hyperparathyroidism. In primary hyperparathyroidism, approximately 90% of the patients have an adenoma of the parathyroid glands and hypercalcemia is usually seen in this disorder. On the other hand, patients with secondary hyperparathyroidism have hyperplasia of all four parathyroid glands and hypocalcemia. Although in the two above-described abnormalities the amount of parathyroid tissue is enlarged and the secretion of PTH increased, it will seem that other mechanisms also are involved in the abnormal secretion of PTH observed in these patients.
KeywordsParathyroid Hormone Parathyroid Gland Hormone Secretion Secondary Hyperparathyroidism Parathyroid Tissue
Unable to display preview. Download preview PDF.
- 2.D.H. Copp and G.F. Davidson, Direct humoral control of parathyroid function in the dog, Proc. Soc. Exp. Biol. Med. 107: 1342 (1961).Google Scholar
- 9.L.R. Dufresne, and H.J. Gitelman, A possible role of adenyl cyclase in the regulation of parathyroid activity by calcium, in: “Calcium, Parathyroid Hormone and the Calcitonins,” R.V. Talmage and P.L. Munson, eds., Excerpta Medica Foundation, Amsterdam (1.972).Google Scholar
- 13.D.A. Ontjes, D.D. Mahaffee, and S.A. Wells, Adenylate cyclase activity in human parathyroid tissues: reduced sensitivity to suppression by calcium in parathyroid adenomas as compared with normal glands from normocalcemic subjects or noninvolved glands from hyperparathyroid subjects, Metabolism 30: 406 (1981).PubMedCrossRefGoogle Scholar
- 15.J.A. Fisher, and J.W. Blum, Non-calcemic control of parathyroid hormone secretion, Min. Electr. Metab. 3: 158 (1980).Google Scholar
- 16.E.M. Brown, PTH secretion in vivo and in vitro: Regulation by calcium and other secretagogues, Min. Electr. Metab. 8: 130 (1982).Google Scholar
- 17.E.M. Brown, D.G. Gardner, R.A. Windeck, S. Hurwitz, M.F. Brennan, and G.D. Aurbach, ß-adrenergically stimulated adenosine 3’,5’-monophosphate accumulation in and parathyroid hormone release from dispersed human parathyroid cells, J. Clin. Endocrinol. Metab. 48: 618 (1979).PubMedCrossRefGoogle Scholar
- 28.D.A. Hanley, K. Takatsuki, M.E. Birnbaumer, A.B. Schneider, and L.M. Sherwood, In vitro perfusion for the study of parathyroid hormone secretion: effects of extracellular calcium concentration and beta-adrenergic regulation on bovine parathyroid hormone secretion in vitro, Calcif. Tiss. Internat. 32:19 (1980).CrossRefGoogle Scholar
- 29.S.I. Roth and C.C. Capen, Ultrastructural and functional correlations of the parathyroid gland, in: “International Review of Experimental Pathology”, Vol. 13, G.W. Richter and M.A. Epstine, eds., Academic Press, New York (1974).Google Scholar
- 31.E.M. Brown, M.F. Brennan, S. Hurwitz, R. Windeck, S.J. Marx, A.M. Spiegel, J.0. Koehler, D.G. Gardner, and G.D. Aurbach, Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia, J. Clin. Endocrinol. Metab. 46: 267 (1978).PubMedCrossRefGoogle Scholar
- 32.E.M. Brown, Set-point for calcium: Its role in normal and abnormal parathyroid secretion, in: “Hormonal Control of Calcium Metabolism,” D. V. Cohn, R.V., Talmage, and J.L. Matthews, eds., Excerpta Medica, Amsterdam (1981).Google Scholar
- 35.E. Slatopolsky, C. Weerts, J. Thielan, K. Martin, and H. Harter, Marked suppression of secondary hyperparathyroidism by intravenous 1,25(OH)2D in uremic patients, Program Abstracts, 15th Annual Meeting of The American Society of Nephrology, 69A (1982).Google Scholar