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The Myopathy of Experimental Magnesium Deficiency

  • James P. Knochel
  • Robert E. Cronin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

Selective deficiency of magnesium has not been considered to be a cause of structural disorganization pf skeletal muscle cells in man. In contrast, the well-known functional consequences of magnesium depletion and hypomagnesemia appear to affect conduction in perpheral nerves rather than dysfunction at the neuromuscular junction. At the latter location and on the skeletal muscle cell, changes in concentration of magnesium ions required to induce functional alterations are beyond the range of disturbances seen in clinical magnesium deficiency or excess. In humans, experimental magnesium deficiency leads to symptoms of neuromuscular irritability, but these appear to be marked or persistent only when they occur in the presence of hypokalemia and hypocalcemia (1).

Keywords

White Muscle Magnesium Deficiency Convulsive Seizure White Fiber Magnesium Depletion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • James P. Knochel
    • 1
  • Robert E. Cronin
    • 1
  1. 1.Dallas VA Medical CenterUniversity of Texas Southwestern Medical SchoolDallasUSA

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