The Myopathy of Experimental Magnesium Deficiency

  • James P. Knochel
  • Robert E. Cronin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


Selective deficiency of magnesium has not been considered to be a cause of structural disorganization pf skeletal muscle cells in man. In contrast, the well-known functional consequences of magnesium depletion and hypomagnesemia appear to affect conduction in perpheral nerves rather than dysfunction at the neuromuscular junction. At the latter location and on the skeletal muscle cell, changes in concentration of magnesium ions required to induce functional alterations are beyond the range of disturbances seen in clinical magnesium deficiency or excess. In humans, experimental magnesium deficiency leads to symptoms of neuromuscular irritability, but these appear to be marked or persistent only when they occur in the presence of hypokalemia and hypocalcemia (1).


White Muscle Magnesium Deficiency Convulsive Seizure White Fiber Magnesium Depletion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Shils, M.E.: Medicine 48: 61–82, 1969.PubMedCrossRefGoogle Scholar
  2. 2.
    Heggtveit, H.A.: Ann. N.Y. Acad. Sci. 162: 758–765, 1969.PubMedCrossRefGoogle Scholar
  3. 3.
    Lowenhaupt, E., Schulman, M.P., and Greenberg, D.M.: Arch. Path. 49: 427–433, 1950.Google Scholar
  4. 4.
    Ko, K.W., Fellers, F.X., and Craig, J.M.: Lab. Invest. 11: 294–305, 1962.PubMedGoogle Scholar
  5. 5.
    Robeson, B.L., Martin, W.G., and Friedman, M.H.: J. Nutr. 110: 2078–2084, 1980.PubMedGoogle Scholar
  6. 6.
    Moore, L.A., Hallman, E.T., and Sholl, L.B.: Arch. Path. 26: 820–838, 1938.Google Scholar
  7. 7.
    Cronin, R.E., Ferguson, E.R., Shannon, W.A., Jr., and Knochel, J.P.: Am. J. Physiol. 243: F113–120, 1982.PubMedGoogle Scholar
  8. 8.
    Sreter, F.A., and Woo, G.: Am. J. Physiol. 205: 1290–1294, 1963.PubMedGoogle Scholar
  9. 9.
    Chutkow, J.G.: Proc. Soc. Exp. Biol. Med. 143: 430–432, 1973.Google Scholar
  10. 10.
    Heggtveit, H.A., Herman, L., and Mishra, R.K.: Am. J. Path. 45: 757–782, 1964.PubMedGoogle Scholar
  11. 11.
    Reddy, C.R., Coburn, J.W., Hartenbower, D.L., Friedler, R.M., Brickman, A.S., Massry, S.G., and Jowsey, J.: J. Clin. Invest. 52: 3000–3010, 1973.PubMedCrossRefGoogle Scholar
  12. 12.
    Elfin, R.J., Armstrong, W.D., and Singer, L.: Am. J. Physiol. 220: 543–548, 1971.Google Scholar
  13. 13.
    Maclntyre, I. and Davidsson, D.: Biochem. J. 70: 456–462, 1958.Google Scholar
  14. 14.
    Whang, R., and Welt, L.G: J. Clin. Invest. 42: 305–313, 1963.PubMedCrossRefGoogle Scholar
  15. 15.
    Chutkow, J.G.: Mayo Clin. Proc. 49: 448–454, 1974.PubMedGoogle Scholar
  16. 16.
    Grace, N.D., and O’Dell, B.L.: J. Nutr. 100: 45–50, 1970.PubMedGoogle Scholar
  17. 17.
    Ryan, M.P., and Hingerty, D.: I. J. Med. Sci. 2: 137–140, 1969.CrossRefGoogle Scholar
  18. 18.
    Fuller, T.J., Carter, N.W., Barcenas, C., and Knochel, J.P.: J. Clin. Invest. 57: 1019–1024, 1976.PubMedCrossRefGoogle Scholar
  19. 19.
    Ferguson, E.R., Blachley, J.D., and Knochel, J.P.: Trans. Assoc. Am. Phys. 95: 61–72, 1981.Google Scholar
  20. 20.
    Blachley, J.D., Ferguson, E.R., Carter, N.W., and Knochel, J.P.: Trans. Assoc. Am. Phys. 93: 110–122, 1980.Google Scholar
  21. 21.
    Anderson, R., Haller, R., Elms, J., Carter, N.W., and Knochel, J.P.: Miner. Electrolyte Metab. 4: 106–112, 1980.Google Scholar
  22. 22.
    Knochel, J.P., Bilbrey, G.L., Fuller, T.J., and Carter, N.W.: Ann. NY Acad. Sci. 252: 274–286, 1975.PubMedCrossRefGoogle Scholar
  23. 23.
    Knochel, J.P., and Schlein, E.M.: J. Clin. Invest. 51: 1750–1758, 1972.PubMedCrossRefGoogle Scholar
  24. 24.
    Knochel, J.P.: Trans. Assoc. Am. Phys. 91: 156–168, 1978.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • James P. Knochel
    • 1
  • Robert E. Cronin
    • 1
  1. 1.Dallas VA Medical CenterUniversity of Texas Southwestern Medical SchoolDallasUSA

Personalised recommendations