Abstract
Vanadate has been recognized as an inhibitor of (Na+, K+)-ATPase (1, 5). Several groups have emphasized it’s potential role as a regulator of the enzyme in the kidney (6), an organ where vanadium tends to accumulate (7). In the dog, intraarterial infusion of vanadate produces a marked vasoconstriction, a decrease in renal blood flow and glomerular filtration rate as well as a decrease in urine flow and sodium excretion (8, 9). In addition to the hemodynamic changes there is also a decrease in renin secretion (10, 11), suggesting that the vasoconstriction is a direct result of the inhibition of the vascular ATPase system. Inhibition by vanadate of sodium or calcium pumps may increase the influx of Ca++ or reduce its efflux from the cytoplasm of muscle cell. This increase in cytoplasmic Ca++ may serve as a stimulus for vasoconstriction.
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© 1984 Plenum Press, New York
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Benabe, J.E., Martínez-Maldonado, M. (1984). Importance of Calcium in the Renal Hemodynamic Changes Induced by Vanadate. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_42
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DOI: https://doi.org/10.1007/978-1-4684-4808-5_42
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